A multifunctional targeted drug delivery platform (CDHA–MGO) has been successfully constructed by grafting β-cyclodextrin–hyaluronic acid polymers (CDHA) to Fe₃O₄–graphene oxide (MGO). The obtained CDHA–MGO nanocomposite has good water-dispersibility, easy magnetic separation, high near-infrared (NIR) photothermal heating, and excellent biocompatibility. The β-cyclodextrin-hyaluronic acid polymers efficaciously enhance the doxorubicin (DOX) loading amount up to 485.43 mg·g⁻¹. Meanwhile, the Fe₃O₄–graphene oxide provides a facile photothermal response mechanism to handle the NIR-triggered release of DOX in weak acidic solvent environments. Significantly, the DOX-loaded nanocomposite (DOX@CDHA–MGO) has displayed CD44 receptor-mediated active targeting recognition and chemo-photothermal synergistic therapy of hepatoma cells. These findings suggest that the as-prepared drug delivery platform would be of valuable potential for cancer-targeted photo-chemotherapy.

A nano-drug carrier, FDCA-FA-MNPs was constructed by modifying Fe ₃ O ₄ magnetic nanoparticles (MNPs) with formyl deoxycholic acid (FDCA) and folic acid (FA) with double-targeting, pH-triggered drug release and excellent tumor cell killing efficiency.

GO@LM-SP-FA was constructed by connecting linear maltodextrin polymer and folic acid to the surface of graphene oxide nanoparticles. Doxorubicin hydrochloride was loaded into GO@LM-SP-FA to form GO@LM-SP-FA/DOX, and controlled release of anticancer drugs was realized.