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The current research direction is the clinical research and translational research of pathogenesis, comorbidity and outcome analysis of allergic diseases and renal diseases in children.
Although studies have suggested environmental factors to be triggers of headache, the contribution of long-term air pollution exposure to recurrent headaches is poorly understood. Hence, we executed this nationwide cohort study to investigate associations between levels of ambient air pollutants and risks of recurrent headaches in children in Taiwan from 2000 to 2012. We used data from the Taiwan National Health Insurance Research Database and linked them to the Taiwan Air Quality Monitoring Database. Overall, 218,008 children aged < 18 were identified from 1 January 2000, and then followed until they were diagnosed by a physician for ≥3 times with recurrent headaches or until 31 December 2012. We categorized the annual average concentration of each air pollutant (fine particulate matter, total hydrocarbon, methane, sulfur dioxide, and nitrogen dioxide) into quartiles (Q1–Q4). We measured the incidence rate, hazard ratios (HRs), and the corresponding 95% confidence intervals for recurrent headaches. stratified by the quartiles. A total of 28,037 children (12.9%) were identified with recurrent headaches. The incidence rate and adjusted HR for recurrent headaches increased with higher-level exposure of air pollutants, except sulfur dioxide. We herein demonstrate that long-term ambient air pollutant exposure might be a risk factor for childhood recurrent headaches.
Syuan-Yu Hong; Lei Wan; Hui-Ju Lin; Cheng-Li Lin; Chang-Ching Wei. Long-Term Ambient Air Pollutant Exposure and Risk of Recurrent Headache in Children: A 12-Year Cohort Study. International Journal of Environmental Research and Public Health 2020, 17, 9140 .
AMA StyleSyuan-Yu Hong, Lei Wan, Hui-Ju Lin, Cheng-Li Lin, Chang-Ching Wei. Long-Term Ambient Air Pollutant Exposure and Risk of Recurrent Headache in Children: A 12-Year Cohort Study. International Journal of Environmental Research and Public Health. 2020; 17 (23):9140.
Chicago/Turabian StyleSyuan-Yu Hong; Lei Wan; Hui-Ju Lin; Cheng-Li Lin; Chang-Ching Wei. 2020. "Long-Term Ambient Air Pollutant Exposure and Risk of Recurrent Headache in Children: A 12-Year Cohort Study." International Journal of Environmental Research and Public Health 17, no. 23: 9140.
Allergic inflammatory diseases are a global public health concern affecting millions of people. Although there are several potential hypotheses, details regarding their molecular mechanisms are still ambiguous. Recently, a group of β-galactoside-binding proteins, galectins, have been revealed as important factors in altering allergic chronic inflammatory diseases. In this review, we describe the molecular and cellular basis of how galectins modulate inflammatory reactions. We also provide an overview of clinical features related to galectins. Finally, we discuss the potential issues that might lead to misrepresentation of the exact biological functions of galectins.
Lei Wan; Yu-An Hsu; Chang-Ching Wei; Fu-Tong Liu. Galectins in allergic inflammatory diseases. Molecular Aspects of Medicine 2020, 79, 100925 .
AMA StyleLei Wan, Yu-An Hsu, Chang-Ching Wei, Fu-Tong Liu. Galectins in allergic inflammatory diseases. Molecular Aspects of Medicine. 2020; 79 ():100925.
Chicago/Turabian StyleLei Wan; Yu-An Hsu; Chang-Ching Wei; Fu-Tong Liu. 2020. "Galectins in allergic inflammatory diseases." Molecular Aspects of Medicine 79, no. : 100925.
Background:There is growing evidence that air pollution may act as an important environmental risk factor in the development and aggravation of childhood atopic dermatitis (AD). Methods:We collected data from the Taiwan National Health Insurance research database and linked the data to the Taiwan Air Quality-Monitoring Database. Children younger than 18 years old between January 1st, 2000 and until the diagnosis of AD was made, or December 31st, 2012, were selected from the database. We measured the incidence rate and hazard ratios for AD, and stratified by quartiles (Q1-Q4) of air pollutant concentration. Multivariable Cox proportional hazards models were also applied by adjusting for age, sex, monthly income, and level of urbanization. Results:Compared with those exposed to the concentrations in the Q1 quartile, the adjusted hazard ratio (HR) for AD increased, and total hydrocarbon (THC), non-methane hydrocarbon (NMHC), and methane (CH4) exposure concentrations ranged from 1.65 to 10.6, from 1.14 to 2.47, and from 1.70 to 11.9, respectively. Patients exposed to higher levels of THC, NMHC, and CH4 had greater accumulative incidence rates of childhood AD. Conclusions:The current study demonstrated that exposure to higher concentrations of THC, NMHC, and CH4 were associated with an increased risk of childhood AD.
Chieh Wang; Jeng-Dau Tsai; Lei Wan; Cheng-Li Lin; Chang-Ching Wei. Association of Exposure to Hydrocarbons Air Pollution with Incidence of Atopic Dermatitis in Children. 2020, 1 .
AMA StyleChieh Wang, Jeng-Dau Tsai, Lei Wan, Cheng-Li Lin, Chang-Ching Wei. Association of Exposure to Hydrocarbons Air Pollution with Incidence of Atopic Dermatitis in Children. . 2020; ():1.
Chicago/Turabian StyleChieh Wang; Jeng-Dau Tsai; Lei Wan; Cheng-Li Lin; Chang-Ching Wei. 2020. "Association of Exposure to Hydrocarbons Air Pollution with Incidence of Atopic Dermatitis in Children." , no. : 1.
Background:Fine particulate matter (PM2.5) has been linked to induction of oxidative stress as well as pulmonary and systemic inflammation. We hypothesized that ambient PM2.5 variation would be associated with the occurrence of childhood-onset systemic lupus erythematosus (cSLE). Methods:We collected data from the Taiwan National health insurance research database and linked these data to the Taiwan Air Quality-Monitoring Database. Children Results:A total of 394 children (0.16%) were newly diagnosed with cSLE during the observation period. The incidence rate for cSLE increased with PM2.5 levels, from 4.7 (Q1) to 21.9 (Q4) per 100,000 person-years. Compared with those exposed to the concentrations in the Q1 level, the adjusted HR from Q2 to Q4 for cSLE increased with PM2.5 exposure concentrations from 2.74 to 4.23. Conclusions:The present study provides evidence that long-term variations in PM2.5 levels are risk factors for the development of cSLE.
Chen-Hao Mai; Yen-Ju Shih; Cheng-Li Lin; Lei Wan; Chang-Ching Wei. Associarions Between Fine Particulate Matter (PM2.5) and Childhood-Onset Systemic Lupus Erythematosus. 2020, 1 .
AMA StyleChen-Hao Mai, Yen-Ju Shih, Cheng-Li Lin, Lei Wan, Chang-Ching Wei. Associarions Between Fine Particulate Matter (PM2.5) and Childhood-Onset Systemic Lupus Erythematosus. . 2020; ():1.
Chicago/Turabian StyleChen-Hao Mai; Yen-Ju Shih; Cheng-Li Lin; Lei Wan; Chang-Ching Wei. 2020. "Associarions Between Fine Particulate Matter (PM2.5) and Childhood-Onset Systemic Lupus Erythematosus." , no. : 1.
Background Although research has suggested environmental factors to be triggers of headache, the contribution of long-term air pollution exposure to migraine and recurrent headaches (migraine/headaches) is poorly understood. Hence, we executed this nationwide cohort study to investigate the association of levels of ambient air pollution with the incidence and the risk of migraine/headaches in Taiwan children from 2000 to 2012. Methods We collected data from the Taiwan National Health Insurance Research Database and linked them to the Taiwan Air Quality Monitoring Database. Overall 218,008 children aged =3 times with migraine/headaches or until December 31, 2012. We categorized the annual average concentration of each air pollutant (fine particulate matter, total hydrocarbon, methane, sulfur dioxide, and nitrogen dioxide) into quartiles (Q1-Q4). We measured the incidence rate, hazard ratios (HRs), and the corresponding 95% confidence intervals for migraine/headaches stratified by the quartiles. Results A total of 28037 children (12.9%) were identified with migraine/headaches. The incidence rate and adjusted HR for migraine/headaches increased with higher-level exposure of air pollutants, except sulfur dioxide. Conclusions We herein demonstrate that long-term ambient air pollutant exposure might be a risk factor for childhood migraine/headaches.
Syuan-Yu Hong; Lei Wan; Hui-Ju Lin; Cheng-Li Lin; Chang-Ching Wei. Long-term ambient air pollutant exposure and risk of migraine and recurrent headache in children: A 12-year cohort study. 2020, 1 .
AMA StyleSyuan-Yu Hong, Lei Wan, Hui-Ju Lin, Cheng-Li Lin, Chang-Ching Wei. Long-term ambient air pollutant exposure and risk of migraine and recurrent headache in children: A 12-year cohort study. . 2020; ():1.
Chicago/Turabian StyleSyuan-Yu Hong; Lei Wan; Hui-Ju Lin; Cheng-Li Lin; Chang-Ching Wei. 2020. "Long-term ambient air pollutant exposure and risk of migraine and recurrent headache in children: A 12-year cohort study." , no. : 1.
Background Despite controversy, an association between allergy and nocturnal enuresis (NE) has been reported for almost a century. Allergic rhinitis (AR)‐associated sleep‐disordered breathing frequently results in microarousals during sleep, decreased sleep efficiency, and change in sleep pattern and behavior. NE is a common sleep disorder in children. Hence, this study aimed to investigate the incidence and risk of NE in children with AR. Methods A population‐based cohort study was conducted among 327,928 children with AR and 327,601 non‐AR controls between 2000 and 2012 in Taiwan. By the end of 2012, the incidence of NE in both cohorts, and the AR‐to‐non‐AR cohort hazard ratios (HRs) were measured. Results The adjusted HR of NE during the study period was 1.7‐fold higher in the AR cohort compared to the non‐AR cohort. The risk was greater for boys, children younger than 6 years old, those with comorbidities of asthma, atopic dermatitis, and attention deficit/hyperactivity disorder (ADHD), and those who had more than 5 AR‐related medical visits per year. The risk of NE in the AR cohort decreased with follow‐up time and was the highest within the first year after AR diagnosis. Conclusion Children with AR had a higher incidence and subsequent risk of NE. The risk of NE was greater for boys, younger children, and those with more frequent health utilization for AR symptoms.
Pei-Hsuan Lai; Pei-Shan Yang; Wan-Yu Lai; Cheng-Li Lin; Chung-Y Hsu; Chang-Ching Wei. Allergic rhinitis and the associated risk of nocturnal enuresis in children: a population-based cohort study. International Forum of Allergy & Rhinology 2018, 8, 1260 -1266.
AMA StylePei-Hsuan Lai, Pei-Shan Yang, Wan-Yu Lai, Cheng-Li Lin, Chung-Y Hsu, Chang-Ching Wei. Allergic rhinitis and the associated risk of nocturnal enuresis in children: a population-based cohort study. International Forum of Allergy & Rhinology. 2018; 8 (11):1260-1266.
Chicago/Turabian StylePei-Hsuan Lai; Pei-Shan Yang; Wan-Yu Lai; Cheng-Li Lin; Chung-Y Hsu; Chang-Ching Wei. 2018. "Allergic rhinitis and the associated risk of nocturnal enuresis in children: a population-based cohort study." International Forum of Allergy & Rhinology 8, no. 11: 1260-1266.
Atropine and orthokeratology (OK) are both effective in slowing the progression of myopia. In the current study, we studied the combined effects of atropine and OK lenses on slowing the progression of myopia. This retrospective study included 84 patients who wore OK lenses and received atropine treatment (OA) and 95 patients who wore OK lenses alone (OK) for 2 years. We stratified patients into low (<6 D, LM) and high (≥6 D, HM) myopia groups, as well as two different atropine concentrations (0.125% and 0.025%). Significantly better LM control was observed in OA1 patients, compared with OK1 patients. Axial length was significantly shorter in the OA1 group (24.67 ± 1.53 mm) than in the OK1 group (24.9 ± 1.98 mm) (p = 0.042); similarly, it was shorter in the OA2 group (24.73 ± 1.53 mm) than in the OK2 group (25.01 ± 1.26 mm) (p = 0.031). For the HM patients, OA3 patients compared with OK3 patients, axial length was significantly shorter in the OA3 group (25.78 ± 1.46 mm) than in the OK3 group (25.93 ± 1.94 mm) (p = 0.021); similarly, it was shorter in the OA4 patients (25.86 ± 1.21 mm) than in the OK4 patients (26.05 ± 1.57 mm) (p = 0.011). Combined treatment with atropine and OK lenses would be a choice of treatment to control the development of myopia.
Lei Wan; Chang-Ching Wei; Chih Sheng Chen; Ching-Yao Chang; Chao-Jen Lin; Jamie Jiin-Yi Chen; Peng-Tai Tien; Hui-Ju Lin. The Synergistic Effects of Orthokeratology and Atropine in Slowing the Progression of Myopia. Journal of Clinical Medicine 2018, 7, 259 .
AMA StyleLei Wan, Chang-Ching Wei, Chih Sheng Chen, Ching-Yao Chang, Chao-Jen Lin, Jamie Jiin-Yi Chen, Peng-Tai Tien, Hui-Ju Lin. The Synergistic Effects of Orthokeratology and Atropine in Slowing the Progression of Myopia. Journal of Clinical Medicine. 2018; 7 (9):259.
Chicago/Turabian StyleLei Wan; Chang-Ching Wei; Chih Sheng Chen; Ching-Yao Chang; Chao-Jen Lin; Jamie Jiin-Yi Chen; Peng-Tai Tien; Hui-Ju Lin. 2018. "The Synergistic Effects of Orthokeratology and Atropine in Slowing the Progression of Myopia." Journal of Clinical Medicine 7, no. 9: 259.
Trends of epilepsy in children were correlated with febrile seizure (FS) in a previous retrospective study. In the present study, the authors obtained relevant data from a nationwide cohort database to investigate trends in subsequent epilepsy in children with a history of recurrent FS. A total of 10,210 children with FS comprised the cohort. The diagnosis date was used as the index date. A comparison cohort was randomly matched with each case based on age, sex, urbanization level, parents’ occupation, and index date. Cox proportional hazard regression was performed to estimate the hazard ratio and confidence interval of FS-associated epilepsy. This retrospective cohort study included 7729 children with FS and a comparison cohort of 30,916 children. The incidence of epilepsy was 11.4-fold higher in the FS cohort than in the comparison cohort (5.67 vs. 0.49 per 1000 person-years, respectively). Compared with the comparison cohort, the epilepsy incidence rate ratio increased in children with admissions for FS, from 8.62 at 1 admission to 26.2 at ≥2 admissions (95% CI 6.80–10.9, and 19.78–34.8, respectively; p for trend < 0.0001). FS may increase the risk for subsequent epilepsy in children. Recurrent FS increased the cumulative incidence of epilepsy.
Jeng-Dau Tsai; Chih-Hsin Mou; Hsing-Yi Chang; Tsai-Chung Li; Henry J. Tsai; Chang-Ching Wei. Trend of subsequent epilepsy in children with recurrent febrile seizures: A retrospective matched cohort study. Seizure 2018, 61, 164 -169.
AMA StyleJeng-Dau Tsai, Chih-Hsin Mou, Hsing-Yi Chang, Tsai-Chung Li, Henry J. Tsai, Chang-Ching Wei. Trend of subsequent epilepsy in children with recurrent febrile seizures: A retrospective matched cohort study. Seizure. 2018; 61 ():164-169.
Chicago/Turabian StyleJeng-Dau Tsai; Chih-Hsin Mou; Hsing-Yi Chang; Tsai-Chung Li; Henry J. Tsai; Chang-Ching Wei. 2018. "Trend of subsequent epilepsy in children with recurrent febrile seizures: A retrospective matched cohort study." Seizure 61, no. : 164-169.
The association between migraine and allergy has remained a subject of debate for more than a century. To systemically investigate the interaction between children with antecedent allergic diseases and their future risks of migraine on reaching school age, we recruited 16,130 children aged 7–18 with migraine diagnosed between 2000 and 2008, and 64,520 matched controls without a history of migraine. The ORs of migraine were calculated for the association with allergic diseases diagnosed before migraine diagnosis. The allergic diseases included atopic dermatitis, allergic conjunctivitis, allergic rhinitis (AR), and asthma. Children with preceding allergic diseases had a greater subsequent risk of migraine than the controls. Among the four evaluated diseases, AR had the highest adjusted OR (aOR) of 2.17 (95% CI 2.09 to 2.26). Children with all four allergic diseases had the highest aOR of 3.59 (95% CI 2.91 to 4.44). Further, an increasing trend of aORs was observed with more allergic disease-associated medical consulting. Our study indicates that children with allergic diseases are at increased subsequent risk of migraine when they reach school age, and the risk shows a cumulative effect of more allergic diseases and more allergy-related healthcare.
Chang-Ching Wei; Cheng-Li Lin; Te-Chun Shen; An-Chyi Chen. Children with allergic diseases have an increased subsequent risk of migraine upon reaching school age. Journal of Investigative Medicine 2018, 66, 1064 -1068.
AMA StyleChang-Ching Wei, Cheng-Li Lin, Te-Chun Shen, An-Chyi Chen. Children with allergic diseases have an increased subsequent risk of migraine upon reaching school age. Journal of Investigative Medicine. 2018; 66 (7):1064-1068.
Chicago/Turabian StyleChang-Ching Wei; Cheng-Li Lin; Te-Chun Shen; An-Chyi Chen. 2018. "Children with allergic diseases have an increased subsequent risk of migraine upon reaching school age." Journal of Investigative Medicine 66, no. 7: 1064-1068.
Te-Chun Shen; Pei-Ying Chang; Cheng-Li Lin; Chang-Ching Wei; Chih-Yen Tu; Te-Chun Hsia; Chuen-Ming Shih; Wu-Huei Hsu; Fung-Chang Sung; Chia-Hung Kao. Reply from authors: RE: Risk of periodontal disease in patients with asthma: A nationwide population-based retrospective cohort study. Journal of Periodontology 2018, 89, 518 -518.
AMA StyleTe-Chun Shen, Pei-Ying Chang, Cheng-Li Lin, Chang-Ching Wei, Chih-Yen Tu, Te-Chun Hsia, Chuen-Ming Shih, Wu-Huei Hsu, Fung-Chang Sung, Chia-Hung Kao. Reply from authors: RE: Risk of periodontal disease in patients with asthma: A nationwide population-based retrospective cohort study. Journal of Periodontology. 2018; 89 (5):518-518.
Chicago/Turabian StyleTe-Chun Shen; Pei-Ying Chang; Cheng-Li Lin; Chang-Ching Wei; Chih-Yen Tu; Te-Chun Hsia; Chuen-Ming Shih; Wu-Huei Hsu; Fung-Chang Sung; Chia-Hung Kao. 2018. "Reply from authors: RE: Risk of periodontal disease in patients with asthma: A nationwide population-based retrospective cohort study." Journal of Periodontology 89, no. 5: 518-518.
Early life events play a crucial role in the development of irritable bowel syndrome (IBS). Some evidence suggests the phenomenon of cross-organ sensitization between bladder and colon. Whether urinary tract infection (UTI) during infancy is a risk factor of childhood IBS remains to be elucidated. In this retrospective cohort study, we selected 31 788 infants who had UTI between 2000 and 2011 as a UTI cohort and selected 127 152 infants without UTI as a comparison cohort, matched by age, sex and level of urbanization of living area. Incidence density and HRs with CIs of IBS between UTI and non-UTI cohorts were calculated by the end of 2012. The incidence density of IBS during the study period was 1.52-fold higher in the UTI cohort (95% CI 1.38 to 1.67) compared with the non-UTI cohort (2.05 vs 1.32 per 10 000 person-years). The HR of IBS was slightly higher for boys (1.53; 95% CI 1.34 to 1.73) than for girls (1.50; 95% CI 1.29 to 1.73). The HRs for IBS in children with UTI were greater for those with more UTI-related medical visits/per year (>5 visits, HR 61.3; 95% CI 51.8 to 72.6), with longer length of stay of hospitalization (>7 days, HR 1.75; 95% CI 1.36 to 2.24) and with vesicoureteral reflux (VUR) (HR 1.73; 95% CI 1.35 to 2.22) (p
Teck-King Tan; Miguel Saps; Cheng-Li Lin; Chang-Ching Wei. Risks of irritable bowel syndrome in children with infantile urinary tract infection: a 13-year nationwide cohort study. Journal of Investigative Medicine 2018, 66, 998 -1003.
AMA StyleTeck-King Tan, Miguel Saps, Cheng-Li Lin, Chang-Ching Wei. Risks of irritable bowel syndrome in children with infantile urinary tract infection: a 13-year nationwide cohort study. Journal of Investigative Medicine. 2018; 66 (6):998-1003.
Chicago/Turabian StyleTeck-King Tan; Miguel Saps; Cheng-Li Lin; Chang-Ching Wei. 2018. "Risks of irritable bowel syndrome in children with infantile urinary tract infection: a 13-year nationwide cohort study." Journal of Investigative Medicine 66, no. 6: 998-1003.
Irritable bowel syndrome (IBS) is a chronic functional gastrointestinal disorder affecting a large number of people worldwide. Based on the concept of central sensitization, we conducted a population-based cohort analysis to investigate the risk of IBS in children with atopic dermatitis (AD) as one of the first steps in the atopic march. From 2000 to 2007, 1 20 014 children with newly diagnosed AD and 1 20 014 randomly selected non-AD controls were included in the study. By the end of 2008, incidences of IBS in both cohorts and the AD cohort to non-AD cohort hazard ratios (HRs) and CIs were measured. The incidence of IBS during the study period was 1.45-fold greater (95% CI: 1.32 to 1.59) in the AD cohort than in the non-AD cohort (18.8 vs 12.9 per 10 000 person-years). The AD to non-AD HR of IBS was greater for girls (1.60, 95% CI: 1.39 to 1.85) and children≥12 years (1.59, 95% CI: 1.23 to 2.05). The HR of IBS in AD children increased from 0.84 (95% CI: 0.75 to 0.94) for those with ≤3 AD related visits to 16.7 (95% CI: 14.7 to 18.9) for those with >5 visits (P<0.0001, by the trend test). AD children had a greater risk of developing IBS. Further research is needed to clarify the role of allergy in the pathogenesis of IBS.
Jeng-Dau Tsai; I-Chung Wang; Te-Chun Shen; Cheng-Li Lin; Chang-Ching Wei. A 8-year population-based cohort study of irritable bowel syndrome in childhood with history of atopic dermatitis. Journal of Investigative Medicine 2018, 66, 755 -761.
AMA StyleJeng-Dau Tsai, I-Chung Wang, Te-Chun Shen, Cheng-Li Lin, Chang-Ching Wei. A 8-year population-based cohort study of irritable bowel syndrome in childhood with history of atopic dermatitis. Journal of Investigative Medicine. 2018; 66 (4):755-761.
Chicago/Turabian StyleJeng-Dau Tsai; I-Chung Wang; Te-Chun Shen; Cheng-Li Lin; Chang-Ching Wei. 2018. "A 8-year population-based cohort study of irritable bowel syndrome in childhood with history of atopic dermatitis." Journal of Investigative Medicine 66, no. 4: 755-761.
Asthmatic adults who underwent periodontal treatment were at lower risk of hospitalization for adverse respiratory events and mortality than those without periodontal disease. Asthmatic adults should adopt more precautionary oral hygiene and ensure that they undergo regular periodontal health checkups.
Te-Chun Shen; Pei-Ying Chang; Cheng-Li Lin; Chang-Ching Wei; Chih-Yen Tu; Te-Chun Hsia; Chuen-Ming Shih; Wu-Huei Hsu; Fung-Chang Sung; Chia-Hung Kao. Impact of periodontal treatment on hospitalization for adverse respiratory events in asthmatic adults: A propensity-matched cohort study. European Journal of Internal Medicine 2017, 46, 56 -60.
AMA StyleTe-Chun Shen, Pei-Ying Chang, Cheng-Li Lin, Chang-Ching Wei, Chih-Yen Tu, Te-Chun Hsia, Chuen-Ming Shih, Wu-Huei Hsu, Fung-Chang Sung, Chia-Hung Kao. Impact of periodontal treatment on hospitalization for adverse respiratory events in asthmatic adults: A propensity-matched cohort study. European Journal of Internal Medicine. 2017; 46 ():56-60.
Chicago/Turabian StyleTe-Chun Shen; Pei-Ying Chang; Cheng-Li Lin; Chang-Ching Wei; Chih-Yen Tu; Te-Chun Hsia; Chuen-Ming Shih; Wu-Huei Hsu; Fung-Chang Sung; Chia-Hung Kao. 2017. "Impact of periodontal treatment on hospitalization for adverse respiratory events in asthmatic adults: A propensity-matched cohort study." European Journal of Internal Medicine 46, no. : 56-60.
Studies have reported an association between asthma and oral diseases, including periodontal diseases. The aim of this retrospective study was to investigate the risk of periodontal diseases for patients with asthma.
Te-Chun Shen; Pei-Ying Chang; Cheng-Li Lin; Chang-Ching Wei; Chih-Yen Tu; Te-Chun Hsia; Chuen-Ming Shih; Wu-Huei Hsu; Fung-Chang Sung; Chia-Hung Kao. Risk of Periodontal Disease in Patients With Asthma: A Nationwide Population-Based Retrospective Cohort Study. Journal of Periodontology 2017, 88, 723 -730.
AMA StyleTe-Chun Shen, Pei-Ying Chang, Cheng-Li Lin, Chang-Ching Wei, Chih-Yen Tu, Te-Chun Hsia, Chuen-Ming Shih, Wu-Huei Hsu, Fung-Chang Sung, Chia-Hung Kao. Risk of Periodontal Disease in Patients With Asthma: A Nationwide Population-Based Retrospective Cohort Study. Journal of Periodontology. 2017; 88 (8):723-730.
Chicago/Turabian StyleTe-Chun Shen; Pei-Ying Chang; Cheng-Li Lin; Chang-Ching Wei; Chih-Yen Tu; Te-Chun Hsia; Chuen-Ming Shih; Wu-Huei Hsu; Fung-Chang Sung; Chia-Hung Kao. 2017. "Risk of Periodontal Disease in Patients With Asthma: A Nationwide Population-Based Retrospective Cohort Study." Journal of Periodontology 88, no. 8: 723-730.
Backgrounds: Literatures regarding the effects of childhood asthma on the risk of herpes zoster (HZ) is very limited. The aim of this study is to investigate the risks of children developing HZ with asthma. Methods: From the National Health Insurance Research Database, we identified 300,649 patients who had asthma between 2000 and 2007 as an asthma cohort. We identified another matched non-asthma cohort. All subjects were followed until the end of 2008. A Cox model was used to estimate the association of asthma on the risk of HZ. Results: Asthma cohort had significantly higher risk of developing HZ than the comparison cohort (HR=1.15; 95 % CI =1.06-1.26). However, compared to those without regular controller, asthma cohort with regular inhaled corticosteroid (ICS) treatment had slightly increased risk for HZ (HR=1.14; 95% CI=1.01-1.27) but decreased risk for HZ in those with regular combined ICS and Montelukast (HR=0.83; 95% CI=0.69-0.98). Uncontrolled asthma with more than 3-4 times ED visits and admissions per year had 3.72 (CI =1.86-7.47) and 20.5 (CI =10.2-41.2) greater risks for HZ than those without asthma, respectively. Conclusions: Asthma poses an increased risk of zoster, therefore control of asthma is important to minimize risk of HZ.
Su-Jing Chen; Kuang-Hua Huang; Wen-Chen Tsai; Cheng-Li Lin; Yih-Dih Cheng; Chang-Ching Wei. Asthma status is an independent risk factor for herpes zoster in children: a population-based cohort study. Annals of Medicine 2017, 49, 504 -512.
AMA StyleSu-Jing Chen, Kuang-Hua Huang, Wen-Chen Tsai, Cheng-Li Lin, Yih-Dih Cheng, Chang-Ching Wei. Asthma status is an independent risk factor for herpes zoster in children: a population-based cohort study. Annals of Medicine. 2017; 49 (6):504-512.
Chicago/Turabian StyleSu-Jing Chen; Kuang-Hua Huang; Wen-Chen Tsai; Cheng-Li Lin; Yih-Dih Cheng; Chang-Ching Wei. 2017. "Asthma status is an independent risk factor for herpes zoster in children: a population-based cohort study." Annals of Medicine 49, no. 6: 504-512.
OBJECTIVES The aim of the study was to systemically investigate the risk of subsequent irritable bowel syndrome (IBS) in children with antecedent allergic diseases in a population-based case-control study in Taiwan. METHODS We evaluated 11,242 children (age range: 7-18 years) with IBS and 44,968 age- and sex-matched control subjects who had been examined between 2000 and 2008. IBS odds ratios were calculated for children with antecedent allergic diseases, including allergic conjunctivitis, allergic rhinitis, asthma, atopic dermatitis, urticaria, and food allergy. RESULTS Children with antecedent allergic diseases had a greater risk of IBS than did control subjects (P < 0.001). Among the 6 evaluated diseases, the highest adjusted odds ratio of 1.78 was observed with allergic rhinitis (95% confidence interval [CI], 1.69-1.87). With 2 or more allergic diseases, the adjusted odds ratios increased to 2.06 (95% CI, 1.93-2.19) for all subjects, 2.07 (95% CI, 1.88-2.28) for girls, and 2.18 (95% CI, 2.02-2.35) for children 12 years or older. CONCLUSIONS Preschoolers with a history of allergic disease had an increased risk of subsequent IBS development upon reaching school age. This risk increased in the presence of concurrent allergic disease and a higher clinical allergy burden.
Teck-King Tan; An-Chyi Chen; Cheng-Li Lin; Te-Chun Shen; Tsai-Chung Li; Chang-Ching Wei. Preschoolers With Allergic Diseases Have an Increased Risk of Irritable Bowel Syndrome When Reaching School Age. Journal of Pediatric Gastroenterology & Nutrition 2017, 64, 26 -30.
AMA StyleTeck-King Tan, An-Chyi Chen, Cheng-Li Lin, Te-Chun Shen, Tsai-Chung Li, Chang-Ching Wei. Preschoolers With Allergic Diseases Have an Increased Risk of Irritable Bowel Syndrome When Reaching School Age. Journal of Pediatric Gastroenterology & Nutrition. 2017; 64 (1):26-30.
Chicago/Turabian StyleTeck-King Tan; An-Chyi Chen; Cheng-Li Lin; Te-Chun Shen; Tsai-Chung Li; Chang-Ching Wei. 2017. "Preschoolers With Allergic Diseases Have an Increased Risk of Irritable Bowel Syndrome When Reaching School Age." Journal of Pediatric Gastroenterology & Nutrition 64, no. 1: 26-30.
Purpose: To investigate the risk of migraine in children with allergic conjunctivitis (AC). Methods: In this population-based cohort study, 309 138 children with AC and 309 138 non-AC controls were included between 2000 and 2007. By 2008 end, the incidences of migraine in both cohorts, and the AC-to-non-AC cohort hazard ratios (HRs) were measured. Results: The incidence of migraine during the study period was 1.92-fold higher in the AC cohort than in the non-AC cohort. The risk was greater for boys with AC and children aged <6 years. The mean time-interval between physician-diagnosed AC to physician-diagnosed migraine was 3.67 years (SD = 2.19).The risk of migraine development in the AC cohort increased with follow-up time and was highest during 4–5 years after AC diagnosis. The children with AC more likely had migraine without than with aura. Conclusions: Children with AC had a higher incidence and subsequent risk of migraine.
I-Chung Wang; Jeng-Dau Tsai; Te-Chun Shen; Cheng-Li Lin; Tsai-Chung Li; Chang-Ching Wei. Allergic Conjunctivitis and the Associated Risk of Migraine Among Children: A Nationwide Population-based Cohort Study. Ocular Immunology and Inflammation 2016, 25, 802 -810.
AMA StyleI-Chung Wang, Jeng-Dau Tsai, Te-Chun Shen, Cheng-Li Lin, Tsai-Chung Li, Chang-Ching Wei. Allergic Conjunctivitis and the Associated Risk of Migraine Among Children: A Nationwide Population-based Cohort Study. Ocular Immunology and Inflammation. 2016; 25 (6):802-810.
Chicago/Turabian StyleI-Chung Wang; Jeng-Dau Tsai; Te-Chun Shen; Cheng-Li Lin; Tsai-Chung Li; Chang-Ching Wei. 2016. "Allergic Conjunctivitis and the Associated Risk of Migraine Among Children: A Nationwide Population-based Cohort Study." Ocular Immunology and Inflammation 25, no. 6: 802-810.
Epidemiological research reveals that the incidence of allergic diseases and that of autoimmune diseases have been increasing in parallel, raising an interest in a potential link between the two disorders. However, the relationship between Th2-mediated allergic disease and Th1-mediated juvenile idiopathic arthritis (JIA) remains unclear. This population-based case-control study was aimed at investigating the development of childhood-onset allergic diseases and the subsequent risks of JIA. We included 329 children with JIA diagnosed between 2000 and 2008, and 1316 age- and sex-matched controls. The odds ratios of developing JIA were calculated to determine an association with preexisting allergic diseases. The incidence rate of JIA in Taiwan between 2000 and 2008 was 1.33 cases per 100,000 children/year according to the International League of Associations for Rheumatology (ILAR) criteria. The children with a single allergic disease had an increased risk of JIA, with adjusted odds ratios of developing JIA of 1.44 for allergic conjunctivitis (95 % confidence interval [CI], 1.07-1.95), 1.50 for allergic rhinitis (1.15-1.96), and 1.44 for asthma (1.00-2.10). The adjusted odds ratios increased with the number of concurrent allergic diseases from 1.50 (95 % CI, 1.12-2.01) for those with only one allergic disease to 1.72 (1.24-2.38) for those with at least two allergic diseases. The adjusted odds ratios of those with at least two allergic diseases increased to 1.84 (95 % CI, 1.19-2.86) for boys and 2.54 (1.42-4.54) for those older than 12 years. The children who made two or more medical visits for associated allergic diseases per year had an increased risk of JIA. Children with onset of allergic diseases were at increased risk of developing JIA. The increased risk was associated with the cumulative effect of concurrent allergic diseases and frequency of seeking medical care. Further study to investigate the role of Th2-mediated allergic diseases that contribute to the development of Th1-mediated JIA is warranted.
Chien-Heng Lin; Cheng-Li Lin; Te-Chun Shen; Chang-Ching Wei. Epidemiology and risk of juvenile idiopathic arthritis among children with allergic diseases: a nationwide population-based study. Pediatric Rheumatology 2016, 14, 15 .
AMA StyleChien-Heng Lin, Cheng-Li Lin, Te-Chun Shen, Chang-Ching Wei. Epidemiology and risk of juvenile idiopathic arthritis among children with allergic diseases: a nationwide population-based study. Pediatric Rheumatology. 2016; 14 (1):15.
Chicago/Turabian StyleChien-Heng Lin; Cheng-Li Lin; Te-Chun Shen; Chang-Ching Wei. 2016. "Epidemiology and risk of juvenile idiopathic arthritis among children with allergic diseases: a nationwide population-based study." Pediatric Rheumatology 14, no. 1: 15.
Jeng-Dau Tsai; Yu-Ping Hsiao; Cheng-Li Lin; Henry J Tsai; Chang-Ching Wei. Risk of stroke in patients with mycosis fungoides: A nationwide population-based cohort study. International Journal of Stroke 2016, 11, NP48 -NP49.
AMA StyleJeng-Dau Tsai, Yu-Ping Hsiao, Cheng-Li Lin, Henry J Tsai, Chang-Ching Wei. Risk of stroke in patients with mycosis fungoides: A nationwide population-based cohort study. International Journal of Stroke. 2016; 11 (4):NP48-NP49.
Chicago/Turabian StyleJeng-Dau Tsai; Yu-Ping Hsiao; Cheng-Li Lin; Henry J Tsai; Chang-Ching Wei. 2016. "Risk of stroke in patients with mycosis fungoides: A nationwide population-based cohort study." International Journal of Stroke 11, no. 4: NP48-NP49.
Some allergic inflammation-associated mediators have been reported in acute stage of Henoch-Schönlein purpura (HSP). However, the association of children with allergic diseases and their subsequent risks of HSP and HSP nephritis remain unknown. In this study, we included 2,240 children with HSP diagnosed between 2000 and 2008 as well as 8,960 non-HSP controls matched for age, sex, and level of urbanization. The odds ratios (ORs) of HSP were calculated with respect to associations with pre-existing allergic diseases. Children with allergic diseases had an increased subsequent risk of HSP; the lowest adjusted OR (aOR) was 1.33 for allergic conjunctivitis (95% confidence interval (CI): 1.17-1.52) and the highest was 1.68 for asthma (95% CI: 1.48-1.91). The aOR increased to 2.03 (95% CI: 1.80-2.31) in children with at least two allergic diseases. Children who visited medical institutes more often per year for associated allergic diseases had an increased risk of HSP. Of the 2,240 children with HSP, 249 (11%) had HSP nephritis and 45.8% of those with nephritis had history of any allergic disease. Atopic children had an increased subsequent risk of HSP but not an increased risk of HSP nephritis.
An-Chyi Chen; Cheng-Li Lin; Te-Chun Shen; Tsai-Chung Li; Fung-Chang Sung; Chang-Ching Wei. Association between allergic diseases and risks of HSP and HSP nephritis: a population-based study. Pediatric Research 2015, 79, 559 -564.
AMA StyleAn-Chyi Chen, Cheng-Li Lin, Te-Chun Shen, Tsai-Chung Li, Fung-Chang Sung, Chang-Ching Wei. Association between allergic diseases and risks of HSP and HSP nephritis: a population-based study. Pediatric Research. 2015; 79 (4):559-564.
Chicago/Turabian StyleAn-Chyi Chen; Cheng-Li Lin; Te-Chun Shen; Tsai-Chung Li; Fung-Chang Sung; Chang-Ching Wei. 2015. "Association between allergic diseases and risks of HSP and HSP nephritis: a population-based study." Pediatric Research 79, no. 4: 559-564.