Lei Chen

Dr. Lei Chen


Research Focus & Metrics

Academic Career Length

10Years (2017-Present)

(Calculated once Scilit publication data is synced: current year − year of first publication + 1)

Representative Publications

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2 December 2019 in BMC Bioinformatics
Verified
Journal Article
Open access
PDF file
LCLei Chen
Lei Chen
HSHong Song
Hong Song
CWChi Wang
Chi Wang
YCYutao Cui
Yutao Cui
JYJian Yang
Jian Yang
LZLe Zhang
Le Zhang
Background: Malignant liver tumor is one of the main causes of human death. In order to help physician better diagnose and make personalized treatment schemes, in clinical practice, it is often necessary to segment and visualize the liver tumor from abdominal computed tomography images. Due to the large number of slices in computed tomography sequence, developing an automatic and reliable segmentation method is very favored by physicians. However, because of the noise existed in the scan sequence and the similar pixel intensity of liver tumors with their surrounding tissues, besides, the size, position and shape of tumors also vary from one patient to another, automatic liver tumor segmentation is still a difficult task. Results: We perform the proposed algorithm to the Liver Tumor Segmentation Challenge dataset and evaluate the segmentation results. Experimental results reveal that the proposed method achieved an average Dice score of 68.4% for tumor segmentation by using the designed network, and ASD, MSD, VOE and RVD improved from 27.8 to 21, 147 to 124, 0.52 to 0.46 and 0.69 to 0.73, respectively after performing adversarial training strategy, which proved the effectiveness of the proposed method. Conclusions: The testing results show that the proposed method achieves improved performance, which corroborated the adversarial training based strategy can achieve more accurate and robustness results on liver tumor segmentation task.

20 December 2017 in BMC Medical Informatics and Decision Making
Verified
Journal Article
Open access
PDF file
HSHong Song
Hong Song
LCLei Chen
Lei Chen
RGRuiQi Gao
RuiQi Gao
IBIordachescu Ilie Mihaita Bogdan
Iordachescu Ilie Mihaita Bogdan
JYJian Yang
Jian Yang
XYXin Yu
Xin Yu
Schizophrenia is a kind of serious mental illness. Due to the lack of an objective physiological data supporting and a unified data analysis method, doctors can only rely on the subjective experience of the data to distinguish normal people and patients, which easily lead to misdiagnosis. In recent years, functional Near-Infrared Spectroscopy (fNIRS) has been widely used in clinical diagnosis, it can get the hemoglobin concentration through the variation of optical intensity. Firstly, the prefrontal brain networks were constructed based on oxy-Hb signals from 52-channel fNIRS data of schizophrenia and healthy controls. Then, Complex Brain Network Analysis (CBNA) was used to extract features from the prefrontal brain networks. Finally, a classier based on Support Vector Machine (SVM) is designed and trained to discriminate schizophrenia from healthy controls. We recruited a sample which contains 34 healthy controls and 42 schizophrenia patients to do the one-back memory task. The hemoglobin response was measured in the prefrontal cortex during the task using a 52-channel fNIRS system. The experimental results indicate that the proposed method can achieve a satisfactory classification with the accuracy of 85.5%, 92.8% for schizophrenia samples and 76.5% for healthy controls. Also, our results suggested that fNIRS has the potential capacity to be an effective objective biomarker for the diagnosis of schizophrenia. Our results suggested that, using the appropriate classification method, fNIRS has the potential capacity to be an effective objective biomarker for the diagnosis of schizophrenia.

28 October 2020 in Physical and Engineering Sciences in Medicine
Verified
Journal Article
Closed access
PDF file
LCLei Chen
Lei Chen
QLQiang Li
Qiang Li
HSHong Song
Hong Song
RGRuiqi Gao
Ruiqi Gao
JYJian Yang
Jian Yang
WDWeimin Dang
Weimin Dang

9 January 2026 in Applied Sciences
Verified
Journal Article
Open access
PDF file
LCLei Chen
Lei Chen
CLChangliang Li
Changliang Li
YGYixuan Gao
Yixuan Gao
YCYujie Chang
Yujie Chang
ZWZhipeng Wang
Zhipeng Wang
JLJia Limin
Jia Limin
High-resolution remote sensing images are gradually playing an important role in land cover mapping, urban planning, and environmental monitoring tasks. However, current segmentation approaches frequently encounter challenges such as loss of detail and blurred boundaries when processing high-resolution remote sensing imagery, owing to their complex backgrounds and dense semantic content. In response to the aforementioned limitations, this study introduces HMA-UNet, a novel segmentation network built upon the UNet framework and enhanced through a hybrid attention strategy. The architecture’s innovation centers on a composite attention block, where a lightweight split fusion attention (LSFA) mechanism and a lightweight channel-spatial attention (LCSA) mechanism are synergistically integrated within a residual learning structure to replace the stacked convolutional structure in UNet, which can improve the utilization of important shallow features and eliminate redundant information interference. Comprehensive experiments on the WHDLD dataset and the DeepGlobe road extraction dataset show that our proposed method achieves effective segmentation in remote sensing images by fully utilizing shallow features and eliminating redundant information interference. The quantitative evaluation results demonstrate the performance of the proposed method across two benchmark datasets. On the WHDLD dataset, the model attains a mean accuracy, IoU, precision, and recall of 72.40%, 60.71%, 75.46%, and 72.41%, respectively. Correspondingly, on the DeepGlobe road extraction dataset, it achieves a mean accuracy of 57.87%, an mIoU of 49.82%, a mean precision of 78.18%, and a mean recall of 57.87%.

2 August 2026
Verified
Book Chapter
Closed access
PDF file
ZWZhipeng Wang
Zhipeng Wang
LCLei Chen
Lei Chen
Zhipeng WangZhipeng Wang
Zhipeng Wang
JLJia Limin
Jia Limin
YGYixuan Geng
Yixuan Geng

2 August 2026
Verified
Book Chapter
Closed access
PDF file
YCYujie Chang
Yujie Chang
LCLei Chen
Lei Chen
Zhipeng WangZhipeng Wang
Zhipeng Wang
JLJia Limin
Jia Limin
YGYixuan Geng
Yixuan Geng