Objective: To evaluate the clinical and microbiological effects of antimicrobial underwear as an adjunct to standard treatment in women with acute vaginitis. Methods: Sixty reproductive-age women with acute vaginitis received a 7-day intravaginal regimen of metronidazole and miconazole. Participants were assigned either to a group wearing antimicrobial underwear or to a control group wearing non-antimicrobial underwear. Vaginal symptoms and culture results were assessed before and after treatment. Results: The antimicrobial-underwear group showed significant improvement in vaginal symptoms, including discharge (96.7%→6.9% vs. 72.5%→27.5%; p < 0.001), pruritus (37.5% vs. 68.4%; p = 0.044), odor (19.6% vs. 53.8%; p = 0.016), and irritation (36.4% vs. 75%; p = 0.013). Dyspareunia was similar between groups. While no microbiological change was observed in controls (p = 0.950), negative cultures increased from 40% to 80% in the antimicrobial-underwear group (p = 0.018), with marked reductions in Candida spp., Gardnerella vaginalis, E. coli, and Klebsiella spp. Conclusions: Antimicrobial underwear, when used in conjunction with standard treatment, can enhance symptom relief and maintain genital hygiene. By improving the vulvovaginal microenvironment, antimicrobial textiles can reduce moisture and the persistence of pathogens.

Purpose: To compare the relationship between the severity of placenta abruptio and creatinine-fibrinogen ratio (CFR). Patients and Methods: Patients with mild and severe placental abruption were separated. Patients with ≥ 1 maternal complications (eg, DIC, hypovolemic shock, blood transfusion, hysterectomy, acute kidney injury, death) were classified as severe placental abruption, while those without were classified as mild. The two groups were compared in terms of hematological parameters and CFR levels at the time of hospital admission. Results: In the study of patients classified by the severity of placental abruption, there were 107 individuals in the mild group and 51 in the severe group. The severe group had elevated creatinine and diminished fibrinogen levels (p = 0.001 and p < 0.001, respectively). The CFR levels of the severe group was significantly higher (p < 0.001). CFR levels were used for ROC analysis to differentiate mild and severe abruptio placenta. CFR had an AUC value of 0.730 (p < 0.001). CFR cut-off values were 0.1381 with 64.7% sensitivity and 76.6% specificity. In this analysis, logistic regression revealed significantly greater CFR (OR 1.064, 95% CI: 1.010– 1.220; p = 0.019). Conclusion: CFR appears to be an effective indicator for predicting severity of placenta abruptio in pregnant women with placental abruption.