Work-related musculoskeletal disorders (MSDs) remain a global occupational health priority, with recognized limitations in current point-in-time assessment methodologies. This research extends prior computer vision ergonomic assessment approaches by implementing biological proprioceptive feedback principles into a continuous, real-time monitoring system. Unlike traditional periodic ergonomic evaluation methods such as “Rapid Upper Limb Assessment” (RULA), our bio-inspired system translates natural proprioceptive mechanisms—which enable continuous postural monitoring through spinal feedback loops operating at 50–150 ms latencies—into automated assessment technology. The system integrates (1) markerless 3D pose estimation via MediaPipe Holistic (33 anatomical landmarks at 30 FPS), (2) depth validation via Orbbec Femto Mega RGB-D camera (640 × 576 resolution, Time-of-Flight sensor), and (3) proprioceptive-inspired alert architecture. Experimental validation with 40 adult participants (age 18–25, n = 26 female, n = 14 male) performing standardized load-lifting tasks (6 kg) demonstrated that 62.5% exhibited critical postural risk (RULA ≥ 5) during dynamic movement versus 7.5% at static rest, with McNemar test $p<0.001$ (Cohen’s $h=1.22$, 95% CI: 0.91–0.97). The system achieved 95% Pearson correlation between risk elevation and alert activation, with response latency of $42.1\pm 8.3$ ms. This work demonstrates technical feasibility for continuous occupational monitoring. However, long-term prospective studies are required to establish whether continuous real-time feedback reduces workplace injury incidence. The biomimetic design framework provides a systematic foundation for translating biological feedback principles into occupational health technology.