Dmitriy Khrustalev

Dr. Dmitriy Khrustalev


Research Focus & Metrics

Academic Career Length

20Years (2007-Present)

(Calculated once Scilit publication data is synced: current year − year of first publication + 1)

Representative Publications

View All Publications
23 December 2022 in Scientific Reports
Verified
Journal Article
Open access
PDF file
DKDmitriy Khrustalev
Dmitriy Khrustalev
ATArman Tirzhanov
Arman Tirzhanov
AKAnastassiya Khrustaleva
Anastassiya Khrustaleva
MMMarlen Mustafin
Marlen Mustafin
AYAzamat Yedrissov
Azamat Yedrissov
Due to the ever-increasing amount of electronic waste (e-waste) worldwide, the problem of the effective disposal of printed circuit board waste (WPCB), which are environmentally hazardous, difficult to recycle and economically valuable products, has become a major environmental challenge. Conventional WPCB recycling techniques have low efficiency and require tough processing, such as heat treatment and high pressure. This paper presents a new composite material for the manufacture of printed circuit boards (PCB) that can be easily recycled into their original components and reused. In addition, the most valuable PCB components (electronic components containing precious metals) can be easily separated from the printed circuit board and reused. This study demonstrates the benefit of using biodegradable polymers as binders for PCBs in terms of environmentally friendly and efficient recycling.

3 February 2026 in Polymers
Verified
Journal Article
Open access
PDF file
AKAnastassiya Khrustaleva
Anastassiya Khrustaleva
DKDmitriy Khrustalev
Dmitriy Khrustalev
AYAzamat Yedrissov
Azamat Yedrissov
PRPolina Rusyaeva
Polina Rusyaeva
Artyom SavelyevArtyom Savelyev
Artyom Savelyev
VKVladimir Kazantsev
Vladimir Kazantsev
Polymer-based bioactive composites are one of the most rapidly advancing areas in contemporary regenerative medicine. This review aims to identify major trends and knowledge gaps in the development of bioactive polymer composites and examine their translational relevance from a materials design perspective, with a specific focus on synthetic thermoplastic polymer matrices suitable for load-bearing bone scaffold applications and filament-based additive manufacturing. A total of 546 publications spanning 2016–2025 were screened, with 106 selected according to predefined relevance criteria. Bibliometric and content analyses were performed to delineate the primary research trajectories of bioactive composite materials. The results revealed that the majority of studies focused on composites comprising synthetic aliphatic polyesters, primarily polylactic acid (PLA) or polycaprolactone (PCL), reinforced with hydroxyapatite (HA) or bioactive glass (BG), which confer osteoconductivity but rarely achieve multifunctionality. Antimicrobial agents, ion-releasing components, and naturally derived bioactive molecules—associated with biointeractive functionalities and reported effects related to osteogenesis, angiogenesis, and immune modulation—are significantly underrepresented. Fewer than 20% of the investigated studies include in vivo validation, underscoring considerable scope for further preclinical and translational research. This work consolidates current trends in synthetic bioactive polymer composite design and identifies critical directions for future research. The findings of this review provide a structured framework to support the selection of composite fabrication and modification strategies, functional additives, and targeted biological functionalities for next-generation, load-bearing bone tissue engineering materials.

1 August 2008 in Russian Journal of General Chemistry
Verified
Journal Article
Closed access
PDF file
DKDmitriy Khrustalev
Dmitriy Khrustalev
GKG. T. Khamzina
G. T. Khamzina
SFS. D. Fazylov
S. D. Fazylov
ZMZ. M. Muldakhmetov
Z. M. Muldakhmetov
Oxidation of heterocycles of the pyridine series under conditions of microwave irradiation was studied. It is established that oxidation of pyridine and 4-methylpyridine with hydrogen peroxide results in the corresponding N-oxides, and oxidation of 3-(piperidin-2-yl)pyridine gives δ-oximino-δ-(pyridyl-3-N-oxide)-valeric acid.

1 January 2009 in Russian Journal of General Chemistry
Verified
Journal Article
Closed access
PDF file
DKDmitriy Khrustalev
Dmitriy Khrustalev

12 February 2026 in Pharmaceuticals
Verified
Journal Article
Open access
PDF file
Artyom SavelyevArtyom Savelyev
Artyom Savelyev
DKDmitriy Khrustalev
Dmitriy Khrustalev
ILIrina Losseva
Irina Losseva
AYAzamat Yedrissov
Azamat Yedrissov
AKAnastassiya Khrustaleva
Anastassiya Khrustaleva
VKVladimir Kazantsev
Vladimir Kazantsev
Background: Amidst escalating global challenges such as antimicrobial resistance and post-COVID therapeutic gaps, dihydropyrimidines (DHPs) and their thione derivatives have emerged as a highly promising scaffold for drug development. This systematic review aims to consolidate recent advancements (2020–2025) and evaluate the synthetic innovation, structure–activity relationships (SAR), and preclinical potential of these compounds. Methods: A systematic review was conducted according to PRISMA guidelines, searching multiple electronic databases (Scopus, PubMed, Web of Science). Sixty original studies from 2020 to 2025 meeting predefined inclusion criteria were selected for data extraction and qualitative synthesis. Results: The analysis reveals a surge in publications (over 300% since 2020). Key structural modifications, such as N-methylation to improve bioavailability and specific substitutions at C4/C5 positions, significantly enhance biological potency, yielding strong inhibitory effects against viral proteases and cancer cell lines. Notable compounds include the apoptosis inducer LaSOM 65 and multitarget Ru(II)–Biginelli hybrids. Conclusions: This review affirms the timeliness and translational potential of the DHP scaffold. The field shows bright prospects for advancing to phase I trials by 2030, urging intensified exploration to unlock novel pharmaceuticals from this versatile chemotype.

1 May 2008 in Russian Journal of Applied Chemistry
Verified
Journal Article
Closed access
PDF file
DKDmitriy Khrustalev
Dmitriy Khrustalev
ASA. A. Suleimenova
A. A. Suleimenova
SFS. D. Fazylov
S. D. Fazylov
The possibility of preparing 2-amino-4-phenylthiazole from acetophenone, iodine, and thiourea under the conditions of microwave irradiation was studied.