This paper examines how surveying and monitoring improve our knowledge about ancient buildings, allow the interpretation of their structural response and help in the search for the best solutions for their conservation. The case study of Palazzo del Capitano in Mantua (Italy) is analyzed. In particular, the attention is focused on the use of a Terrestrial Laser Scanner (TLS) for surveying and monitoring too, considering that the building structural control has been performed in combination with other traditional topographic techniques such as geometric leveling and topographic networks for 3D control based on measurements through total stations. The study of TLS monitoring has been tested only in the last decade and it is an innovative method for the detection of displacements of particular surfaces. Till now the research has focused only on the use of TLS monitoring to control large structures and in particular landscape situations; thus its use for a civil construction and historical buildings is a new field of investigation. Despite the fact technological development and new methodologies seem offer new future potential for the analysis of ancient buildings, currently there are still important limits for the application of the investigated surveying and monitoring techniques.