Amaç: Bu çalışma, benign nedenlerle histerektomi uygulanan hastalarda tesadüfi olarak tanı alan en-dometrium kanserli olguların klinik özelliklerini ve tedavi yöntemlerini değerlendirmeyi amaçlamaktadır. Materyal ve Metod: Bu retrospektif çalışmada, 15 Ekim 2023 – 15 Ekim 2024 tarihleri arasında benign endikasyonlarla histerektomi sonrası tesadüfen endometrium kanseri tanısı alarak jinekolojik onkoloji kliniğimize yönlendirilen hastaların verileri incelenmiştir. Klinik, patolojik ve cerrahi veriler hastane kayıtlarından elde edilmiş; tanımlayıcı istatistikler ile karşılaştırmalı analizler SPSS 29 programı kullanılarak gerçekleştirilmiştir. Bulgular: Çalışmaya toplam 57 hasta dâhil edildi. Ortalama yaş 53,9 ± 8,2 yıl olup, hastaların %57,9’u postmenopozal dönemdeydi. En sık rastlanan histolojik alt tip %94,7 oranıyla endometrioid tip idi ve olguların %86,0’ında yüzeyel myometriyal invazyon mevcuttu. Preoperatif endometrial örnekleme hastaların %28,1’inde yapılmamıştı. Hastaların %28,1’ine tamamlayıcı cerrahi müdahale planlanırken, %71,9’u konservatif olarak yakın takip ile yönetildi. Patoloji blok revizyonu, jinekolojik onkoloji alanın-da deneyimi olmayan merkezlerde değerlendirilen 15 hastada, tanısal doğruluğu sağlamak amacıyla gerçekleştirilmiştir. Uzman patoloji incelemesi sonucunda bu hastaların 8’inde (%53,3) tanıda değişiklik saptanmıştır. Grade 2–3 tümörlerde derin invazyon, lenvovasküler alan invazyonu ve cerrahi gereksini-mi anlamlı olarak daha yüksek bulundu (p<0,05). Sonuç: Tesadüfen tanı konulan endometrium kanseri olgularında multidisipliner ve risk temelli bir yaklaşım gereklidir. Bu çalışma, özellikle jinekolojik onkoloji deneyimi olmayan merkezlerde raporlanan olgular için yapılan patoloji blok revizyonunun, tedavi kararlarını yönlendirmede önemli katkı sağladığı-nı göstermektedir. Düşük riskli hastalarda konservatif takip güvenli bir seçenek olabilirken, yüksek riskli olgularda zamanında tamamlayıcı cerrahi ve adjuvan tedavi uygulamaları hayati önemdedir.

The optimal management of women with non-16/18 hrHPV infection and normal cytology remains a topic of clinical debate. While immediate colposcopy is often

With increasing life expectancy, a growing proportion of patients undergoing surgery for gynecologic cancers are older adults, underscoring the need for reliable predictors of postoperative recovery and patient engagement. Cognitive function and physical frailty are recognized determinants of surgical outcomes, yet their relative impact on patient centered outcomes remains insufficiently explored. This prospective observational study included 68 women aged 65 years and older who underwent abdominal surgery for gynecologic malignancies. Preoperative cognitive function was assessed using the Montreal Cognitive Assessment, and physical frailty was evaluated with the Clinical Frailty Scale. Postoperative outcomes included early recovery parameters, complications, surgical decision satisfaction, and home-based adherence. Higher cognitive scores were associated with earlier mobilization, shorter hospital stay, better postoperative adherence, and greater decision satisfaction, whereas higher frailty scores were associated with delayed recovery and increased complication risk. In regression analyses, preoperative cognitive function was significantly associated with both postoperative adherence and surgical decision satisfaction, whereas physical frailty was not. These findings indicate that preoperative cognitive screening may have predictive value for patient centered recovery behaviors and decision satisfaction in this setting; however, the prediction estimates should be considered exploratory and warrant validation in larger, multicenter cohorts.

A cyst of the canal of Nuck is a rare clinical entity in females, resulting from the failure of obliteration of the processus vaginalis. Although it is typically diagnosed in the pediatric population, it is extremely rare in adult women and often misdiagnosed as an inguinal hernia, leading to delays in appropriate treatment. Clinically, it usually presents as a painless, fluctuating mass in the inguinal region. Ultrasonography is the primary imaging modality for diagnosis, while magnetic resonance imaging (MRI) can further delineate the origin and anatomical relationships of the lesion. Surgical excision remains the standard treatment approach. Herein, we present the case of a 34-year-old woman who presented with a painless swelling in the left inguinal region. A preoperative diagnosis was established based on imaging findings, and the lesion was surgically excised. Histopathological examination revealed a focus of endometriosis within the cyst wall. This case highlights the importance of considering rare coexisting pathologies such as endometriosis in the differential diagnosis of canal of Nuck cysts in adult women and aims to raise clinical awareness of this uncommon presentation.

Background: Endometriosis is a chronic inflammatory disorder frequently associated with infertility. Tumor necrosis factor-alpha (TNF-α) is involved in inflammatory pathways; however, the clinical relevance of serum TNF-α in relation to infertility duration and ovarian reserve remains uncertain. Methods: This prospective comparative study included 70 infertile women aged 20–37 years: 35 women with clinically and/or radiologically diagnosed endometriosis and 35 age-matched infertile controls with unexplained infertility and no clinical or imaging evidence of endometriosis. Serum TNF-α was measured using enzyme-linked immunosorbent assay. Hormonal parameters, including anti-Müllerian hormone (AMH), were obtained from third-day menstrual-cycle samples retrieved from clinical records. Associations between TNF-α, infertility duration, AMH, and clinical characteristics were evaluated. Exploratory adjusted analyses were performed for log-transformed TNF-α and AMH. Results: Serum TNF-α levels were higher in the endometriosis group than in controls (median [IQR], 235.49 [124.33-390.31] vs. 64.58 [58.91–76.52] ng/L; p < 0.001). AMH levels were lower in the endometriosis group in unadjusted analysis (2.05 [1.67–3.41] vs. 3.30 [2.26–3.66] ng/mL; p = 0.029). After adjustment for age, BMI, smoking status, and previous surgical history, endometriosis group status remained associated with log-transformed TNF-α (β = 1.386, 95% CI 1.114 to 1.657; p < 0.001), whereas the association with AMH was attenuated (β=-0.824, 95% CI -1.817 to 0.169; p = 0.102). TNF-α was not associated with infertility duration or AMH within the endometriosis group. Conclusions: Serum TNF-α was elevated in infertile women with clinically and/or radiologically diagnosed endometriosis but was not associated with infertility duration, AMH, or selected clinical characteristics. The high discriminatory performance observed in ROC analysis should be interpreted as exploratory because of the modest sample size, clinical/radiologic case definition, potential selection bias, and lack of external validation. Serum TNF-α may reflect systemic inflammatory activity rather than infertility severity or ovarian reserve impairment.