Background: An increased number of resources are allocated on cancer biomarker discovery, but very few of these biomarkers are clinically adopted. To bridge the gap between Biomarker discovery and clinical use, we aim to generate the Biomarker Toolkit, a tool designed to identify clinically promising biomarkers and promote successful biomarker translation. Methods: All features associated with a clinically useful biomarker were identified using mixed-methodology, including systematic literature search, semi-structured interviews, and an online two-stage Delphi-Survey. Validation of the checklist was achieved by independent systematic literature searches using keywords/subheadings related to clinically and non-clinically utilised breast and colorectal cancer biomarkers. Composite aggregated scores were generated for each selected publication based on the presence/absence of an attribute listed in the Biomarker Toolkit checklist. Results: Systematic literature search identified 129 attributes associated with a clinically useful biomarker. These were grouped in four main categories including: rationale, clinical utility, analytical validity, and clinical validity. This checklist was subsequently developed using semi-structured interviews with biomarker experts (n=34); and 88.23% agreement was achieved regarding the identified attributes, via the Delphi survey (consensus level:75%, n=51). Quantitative validation was completed using clinically and non-clinically implemented breast and colorectal cancer biomarkers. Cox-regression analysis suggested that total score is a significant driver of biomarker success in both cancer types (BC: p>0.0001, 95.0% CI: 0.869–0.935, CRC: p>0.0001, 95.0% CI: 0.918–0.954). Conclusions: This novel study generated a validated checklist with literature-reported attributes linked with successful biomarker implementation. Ultimately, the application of this toolkit can be used to detect biomarkers with the highest clinical potential and shape how biomarker studies are designed/performed.

This study investigated trait EI in childhood in a Serbian population by validating a Serbian adaptation of the Trait Emotional Intelligence Questionnaire - Child Form (TEIQue-CF). All 606 participants (Mage = 10.33, SD = 1.55) completed the TEIQue-CF, the Reading the Mind in the Eyes Test (revised version), and the Guess Who peer assessment. Data on academic achievement and truancy were also obtained. The Serbian TEIQue-CF demonstrated robust psychometric properties with satisfactory internal consistencies and extensive evidence of validity in relation to criteria such as emotion recognition, academic grades, truancy rates, and peer ratings. Factor analyses suggested a two-factor solution for the total sample, but a unifactorial structure for the two groups of younger children aged 8 to 9 and 10 to 11. Overall, the results corroborate the validity of the Serbian adaptation and the theoretical and practical importance of the construct of trait EI in children.

The psychometric properties of the English version of the Trait Emotional Intelligence Questionnaire (TEIQue v. 1.50; Petrides, 2009) were recently investigated in Lebanon (Sanchez-Ruiz et al., International Journal of Psychology , 56 (2), 304–313, 2020). We extended these findings by further examining the validity of the TEIQue in the Lebanese context through its associations with emotion regulation strategies, depression, procrastination, body image dissatisfaction (BID), and the Big Five personality traits. The results indicated that trait EI was positively correlated with cognitive reappraisal ( r = .14) and negatively correlated with expressive suppression ( r = − .24), highlighting distinct relationships with emotion regulation strategies as evidence of discriminant validity. Additionally, trait EI showed negative correlations with depression, procrastination, and BID, demonstrating strong criterion validity. Hierarchical regression analyses further supported the incremental validity of trait EI, with Self-control predicting procrastination, Well-being predicting BID, and both factors negatively predicting depression, even after controlling for the Big Five. These findings substantiate the validity of the English version of the TEIQue in Lebanon and emphasize its theoretical and practical relevance in predicting key psychopathological and life outcomes.