Laura Fazzini

Dr. Laura Fazzini


Research Focus & Metrics

Academic Career Length

3Years (2024-Present)

(Calculated once Scilit publication data is synced: current year − year of first publication + 1)

Representative Publications

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16 March 2024 in Annals of Vascular Surgery
Verified
Journal Article
Closed access
SMStavros Malatos
Stavros Malatos
LFLaura Fazzini
Laura Fazzini
ARAnastasios Raptis
Anastasios Raptis
PNPetroula Nana
Petroula Nana
GKGeorge N. Kouvelos
George N. Kouvelos
MMMiltiadis Matsagkas
Miltiadis Matsagkas

Verified
Journal Article
Open access
PDF file
SMStavros Malatos
Stavros Malatos
SKSpyridon Charilaos Katsoudas
Spyridon Charilaos Katsoudas
ARAnastasios Raptis
Anastasios Raptis
LFLaura Fazzini
Laura Fazzini
PNPetroula Nana
Petroula Nana
MMMiltiadis Matsagkas
Miltiadis Matsagkas
Background/Objectives: This study compared the hemodynamic performance of fenestrated (FEVAR), branched (BEVAR), and chimney endovascular aortic aneurysm repair (chEVAR) in patients with complex aortic aneurysms. Methods: The pre- (native) and post-endovascular repair (endograft-defined) blood lumen was reconstructed from computed tomography angiographies of nine (9) elective patients treated with FEVAR (n = 3), BEVAR (n = 3), and chEVAR (n = 3). Computational fluid dynamics (CFD) simulations obtained blood flow properties. Velocity magnitude, wall shear stress (WSS), time-averaged wall shear stress (TAWSS), oscillatory shear index (OSI), relative residence time (RRT), and local normalized helicity (LNH) were computed at peak systole and mid-diastole. The hemodynamic data were statistically analyzed to evaluate correlations between FEVAR, BEVAR, and chEVAR, focusing on targeted visceral arteries. Results: Only slight differences were observed regarding RRT, OSI, and TAWSS between FEVAR and BEVAR, whereas the chEVAR group demonstrated a marked deviation from both. In FEVAR, the postoperative helical flow structures appeared more compact, while in BEVAR they were more developed and exhibited a more rotational configuration. The LNH of the visceral vessel patterns exhibited similar qualitative features across groups. Regarding TAWSS, higher values were found in BEVAR, whereas chEVAR showed the lowest. Conclusions: FEVAR, BEVAR, and chEVAR improved postoperative blood flow characteristics toward near-physiological conditions, reducing undesired flow patterns and recirculation zones. FEVAR showed more stable visceral flow, and BEVAR demonstrated higher flow rates and fewer recirculation zones, while chEVAR exhibited more streamlined visceral artery flow with reduced regurgitation at bridging stent entries. Despite variations, all approaches effectively preserved visceral artery perfusion.

22 January 2026 in Preprints.org
Verified
Preprint
Open access
PDF file
SMStavros Malatos
Stavros Malatos
SKSpyridon Charilaos Katsoudas
Spyridon Charilaos Katsoudas
ARAnastasios Raptis
Anastasios Raptis
LFLaura Fazzini
Laura Fazzini
PNPetroula Nana
Petroula Nana
MMMiltiadis Matsagkas
Miltiadis Matsagkas
Background/Objectives: This study compared the hemodynamic performance of fenestrated (FEVAR), branched (BEVAR) and chimney endovascular aortic aneurysm repair (chEVAR) in patients with complex aortic aneurysms. Methods: The pre- (native) and post-endovascular repair (endograft-defined) blood lumen was reconstructed from computed tomography angiographies of nine (9) elective patients treated with FEVAR (n=3), BEVAR (n=3), and chEVAR (n=3). Computational Fluid Dynamics (CFD) simulations obtained blood flow properties. Velocity magnitude, wall shear stress (WSS), time-averaged wall shear stress (TAWSS), oscillatory shear index (OSI), relative residence time (RRT) and local normalized helicity (LNH) were computed at peak-systole and mid-diastole. The hemodynamic data were statistically analyzed to evaluate correlations between FEVAR, BEVAR and chEVAR, focusing on targeted visceral arteries. Results: Only slight differences were observed regarding RRT, OSI and TAWSS between FEVAR and BEVAR, whereas the chEVAR group demonstrated a marked deviation from both. In FEVAR, the postoperative helical flow structures appeared more compact, while in BEVAR, they were more developed and exhibited a more rotational configuration. The LNH of the visceral vessel patterns exhibited similar qualitative features across groups. Regarding TAWSS, higher values were found in BEVAR, whereas chEVAR showed the lowest. Conclusions: FEVAR, BEVAR, and chEVAR improved postoperative blood flow characteristics toward near-physiological conditions, reducing undesired flow patterns and recirculation zones. FEVAR showed more stable visceral flow, BEVAR demonstrated higher flow rates and fewer recirculation zones while chEVAR exhibited more streamlined visceral artery flow with reduced regurgitation at bridging stent entries. Despite variations, all approaches effectively preserved visceral artery perfusion.