The article considers the influence of the mercazolilum management on the hormonal state in the lymph and blood of rates. The study shows that after mercazolilum management and the hypothyroidism signs appearance in rats, there was a decrement of lymph flow from the thoracic lymphatic duct. Changes in the hormonal and biochemical composition of the lymph were observed. There were disturbances not only of the metabolism in the lymph, but also of the functional state of the body. There were disturbances of rheologic and physicochemical parameters of lymph and blood at the experimentative hypothyroidism of rats: viscosity has been increased, coagulability and number of erythrocytes have been decreased, thrombocytes and leucocytes in blood have been increased. It has been led to a decrease of rats of the 2nd experienced group in T3, T4 content and increase of thyrotropic hormone in lymph and blood which reflected the occurrence of their hypothyroidism. Experiments showed that Т3 content in rats with hypothyroidism has decreased by 45.7% and Т4 by 35.6% in lymph, and in blood Т3 by 43,5% and Т4 by 41,6% have decreased compared with the control group of animals.

This paper provides data regarding the ratios of the functional structures of lymph nodes after inflammation in the abdominal organs. Lymph systems, including lymph nodes, function as filters of tissues and tissue fluids and are places of origin and lymphocyte production for normal physiological functions. They display specific morphological and functional responses in reaction to endogenous and exogenous substances. The morphological pattern of the mesenteric lymph node in experimental rat groups reflects a decrease in its immune function due to the processes of inflammation in the abdominal cavity. These processes work together with the associated organs and their involvement in the abdominal lymph nodes, in which there are discharges of the structure of the paracortical zone under conditions of reduced lymphogenic processes, according to the decrease in the size of the paracortex and the ratios of lymphoid nodes with and without germinal centers. Histological and morphometric analyses show changes in the mesenteric lymph node. These analyses are characterized by changes in the cortical and medullary substances, while the proportion of the cortical structure decreases. We also noted an increase in the number of macrophages in the lymphoid nodes and cerebral sinus, as well as a decrease in the number of mature plasmocytes, the paracortex, and the pulp strands. These changes indicate immunosuppressive effects on the lymph node. Under the conditions of inflammation, the formation of a mixed immune response occurs.