Çocuk acil polikliniklerine müracaat eden hastaların büyük bir kısmını Çocuk Nörolojisi hastaları oluşturmaktadır. Acile başvuran bu hastaların tanı ve tedavilerinin acilen planlanması gerekmektedir. Biz hekimler çoğunlukla acil hastaların tanı ve tedavi süresince adeta zamanla yarışmak zorunda kalmaktayız. Böyle durumlarda acilen güvenilir, referans bilgi kaynaklarına ulaşmak büyük önem arz etmektedir.

Background: Childhood asthma is clinically heterogeneous, yet simple clinical approaches for describing concurrent disease burden are limited. We tested whether a two-axis phenotype matrix—built from early-onset and/or high-burden wheeze and atopic load—is associated cross-sectionally with treatment-defined severity and control in school-aged children with asthma. This exploratory, unvalidated classification requires prospective external validation before clinical use. Methods: In a two-center retrospective cross-sectional study, 337 children aged 6–12 years with physician-confirmed asthma were classified into four clinical strata (low-burden, familial/atopic-dominant, wheeze-dominant, atopic-wheezing). The primary outcome was moderate-to-severe asthma, defined by controller treatment step and deliberately independent of acute events. Variables independently associated with the outcomes were identified using multivariable logistic regression with prespecified sensitivity analyses; trends across ordered wheezing-onset categories were assessed using the Cochran–Armitage trend test, adjusted associations were confirmed by likelihood-ratio tests, and secondary outcomes were false-discovery-rate corrected. Results: The atopic-wheezing stratum was the largest group (140/337, 41.5%) and carried the highest burden: moderate-to-severe asthma 49.3% vs. 17.4% in low-burden and uncontrolled asthma 42.1% vs. 13.0% (both q < 0.01). Adverse outcomes were generally more frequent with earlier wheezing onset (moderate-to-severe asthma 26.9% to 57.9% from no early wheeze to onset ≤ 12 months; p for trend <0.001). After adjustment, the atopic-wheezing stratum had the largest adjusted odds ratios for both moderate-to-severe asthma (aOR 4.49, 95% CI 1.91–10.54) and uncontrolled asthma (aOR 4.78, 95% CI 1.85–12.35), and remained significant across all sensitivity analyses. Passive smoke exposure was independently associated with uncontrolled asthma (aOR 1.86, 95% CI 1.13–3.05) but not severity. The FEV1/FVC z-score differed significantly across strata and was lowest in the atopic-wheezing group (median z-score −1.28 vs. +0.10 in low-burden; p < 0.001). Conclusions: The co-occurrence of high atopic load with early-onset or high-burden wheezing defined the clinical stratum with the highest observed treatment requirement and poorest control, using only routine history and standard allergy work-up. Passive smoke exposure was independently associated with uncontrolled asthma.