Objetivo: Avaliar o letramento em saúde dos idosos hipertensos e/ou diabéticos acompanhados pela Estratégia Saúde da Família. Método: Foram selecionados 121 idosos aptos a participarem do estudo. Resultados: A maioria era do sexo feminino, com idade entre 60 e 64 anos, escolaridade básica, e sem ocupação após a aposentadoria. 60,3% possuem letramento baixo. Há uma diferença estatisticamente significante no baixo letramento com as variáveis sexo, faixa etária, escolaridade, e o tipo de ocupação. As mulheres possuem maior nível de letramento, e quanto mais avançada a idade, menor o letramento. A população idosa aposentada demonstrou maior nível de letramento. O tipo de material para leitura mais citado foi a bíblia. Destaca-se um número alto de idosos que relatou não gostar de ler, influenciando a alta prevalência do baixo nível de letramento. Conclusões: Propõe-se aqui, que intervenções que visem garantir a promoção da saúde, devem verificar o nível de letramento dos indivíduos.

Background: Repositioning offers a cost‐effective approach to discovering new therapeutic applications for existing medications. Ambroxol, primarily used as a mucolytic for respiratory diseases, has demonstrated anti‐inflammatory, analgesic, and antioxidant properties, suggesting potential benefits in non‐pulmonary conditions. This study conducted a systematic review to evaluate the efficacy of ambroxol in experimental disease models unrelated to the respiratory system. Methods: Following registration in the Open Science Framework and adherence to the PICO strategy for formulating the guiding question, searches were performed in PUBMED/MEDLINE, EMBASE, and SCOPUS using the keywords: (Ambroxol) AND (Anti‐Inflammatory Agents OR Analgesics OR Antioxidants) AND (Animals OR in vivo). The SYRCLE tool assessed methodological quality. Among 353 identified records, eight articles met eligibility criteria. Results: These studies investigated ambroxol's effects in models of gastric lesions, neuropathic pain, psoriasis‐like skin inflammation, hemorrhagic cystitis, and ischemia/reperfusion injuries in the liver and kidneys. Ambroxol doses ranged from 5 to 1000 mg/kg, predominantly administered orally. Its antioxidant properties were demonstrated by reducing free radicals and increasing enzymatic activity (SOD, CAT, GSH). Anti‐inflammatory effects included a decrease in pro‐inflammatory cytokines (TNF‐α, IL‐1β) and histological improvements. Antinociceptive action was observed through inhibition of voltage‐gated sodium channels and reduction of oxidative stress, alleviating neuropathic pain. Conclusions: Despite ambroxol's widespread clinical use, limited research has explored its non‐respiratory applications. Existing studies suggest its promising therapeutic potential, reinforcing the need for further investigation into its role as an alternative treatment for various inflammatory and oxidative stress–related conditions beyond pulmonary diseases.

Total knee arthroplasty (TKA) surgery is a high risk factor for the occurrence of venous thromboembolism. This represents the main preventable cause of death after major orthopedic surgeries, such as joint replacement surgeries, more than a third of affected patients die suddenly or within a few hours after the first manifestation, that is, before even receiving any type of treatment. Given this, this research aimed to identify the most suitable protocol for thromboprophylaxis in patients undergoing total knee arthroplasty. To this end, an exploratory descriptive study was carried out, an integrative review of the literature from the period 2018 to 2023, in the electronic databases Scielo, Pubmed, Google Acadêmico and RBO. To analyze the articles, the flow diagram was used. All research data was analyzed, subsequently tabulated in Word and the results were presented in tables highlighting the main points for better interpretation of the information collected. The results referring to the bibliography reviewed in this study demonstrated that the advent of new oral anticoagulants (NOACs) resulted in greater adherence, without significant loss of efficacy, resulting in a drop in the number of thromboembolic events up to 60 days after the TKA surgical procedure. With the advent of NOACs, the scientific community is still in debate to determine which protocol holds the title of “most efficient”. As this discussion deepened, we began to consider, in addition to the characteristics of each medication, general and individual aspects of patients recommended for the TKA procedure, thus making VTE prevention increasingly individualized. Therefore, it is concluded, in this review, that the most efficient thromboprophylactic protocol is related to the individual clinical and physiological conditions of each patient.

Ambroxol, also known as Trans-4-(2-amino-3,5-dibromobenzylamino)-cyclohexanol (ABX), is a chemical compound with mucolytic properties used to treat pulmonary diseases such as bronchitis and cystic fibrosis. It enhances mucus clearance in the respiratory tract. Recent studies have suggested its broad therapeutic potential, including analgesic, antioxidant, and anti-inflammatory effects in various clinical contexts. This study aimed to systematically identify research trends and critical points in the pharmacological activities of ambroxol hydrochloride in experimental models. A bibliometric review was conducted, retrieving 24 publications from the Web of Science and Scopus databases without temporal restrictions, using appropriate English keywords. The quality of the publications was assessed using impact metrics, productivity, term density mapping, and author network analysis. The average publication rate was 0.7 articles per year, with significant growth starting in the 2000s, a notable increase between 2016 and 2020, and a peak in 2021 with 5 articles published. China was the country with the highest number of publications. The primary field of publication was medicine (33.3%), and the journals with the best metrics were Intensive Care and Clinical and Experimental Medicine. Keyword co-occurrence analysis identified a complex network of 77 terms, divided into 4 clusters. Co-authorship analysis revealed 139 authors, divided into 21 clusters, with the largest cluster connecting 24 authors. A scarcity of publications addressing the pleiotropic effects of ambroxol in experimental models was observed. This bibliometric review highlights the need for further research in this field to explore new therapeutic approaches and possibilities, leveraging the potential effects of this drug.

The use of digital media in the disseminationof health knowledge is essential in contemporary times, as it promotesthe democratization of this knowledge and establishesa more horizontal relationship between the public university and the surrounding community. Furthermore, the Integrator Axis subjectin the Medicine Course at Federal University of Maranhão (UFMA) offers a valuable opportunity for educational interventions through digital technologies. This study aimsto report on the experiencesof UFMA students in the ‘Saúde nos Eixos’extension project. Its purpose was todevelop a podcast dedicated to health education. It is a descriptive experience report with a qualitative approach. The podcast, anchored on the Spotifystreaming platform, discussed relevant health issues, combining technical rigor andaccessible language. Two episodes were produced in the form ofan interview and an informative dialogue, focusingon the evolution of the doctor-patient relationship in the digital ageandon sporotrichosis, respectively. The experience of the ‘Saúde nos Eixos’project demonstrates the potential of podcasts to democratize health knowledgeand connect the university with the community. It alsohighlights the importance of more in-depth studies to evaluate the educational impactof projects like this.

Background/Objectives: Ambroxol is a mucolytic agent widely used in the treatment of respiratory diseases; however, evidence in the literature indicates anti-inflammatory, analgesic, and immunomodulatory properties, suggesting potential for therapeutic repositioning. This study aimed to evaluate the analgesic and anti-inflammatory effects of ambroxol in an experimental model of osteoarthritis (OA). Methods: Adult male Wistar rats underwent OA induction on day zero (D0) by sodium monoiodoacetate (MIA) injection and were allocated into the following groups: Healthy, negative control (CTRL−), and groups treated with meloxicam (2 mg/kg) or ambroxol (10, 50, and 100 mg/kg). Treatments were administered orally (gavage) once daily for 28 days. Behavioral tests were performed, including rotarod, walkway gait analysis, weight-bearing, Von Frey, and Rat Grimace Scale assessments, along with radiographic and histopathological analyses and quantification of pro- and anti-inflammatory cytokines (IL-1β, IL-6, and IL-10). Results: Ambroxol treatment improved nociceptive parameters and motor function, reduced radiographic and histopathological scores, and showed performance comparable to meloxicam in several tests. There was a marked reduction in IL-1β and IL-6 levels, while IL-10 levels were lower in ambroxol-treated groups, suggesting early control of the inflammatory response. Conclusions: The results indicate that ambroxol exhibits antinociceptive and anti-inflammatory actions and suggest a potential chondroprotective effect, reinforcing its viability as a candidate for therapeutic repositioning in osteoarthritis. Further studies are required to more precisely elucidate its mechanisms of action, define optimal dosing and treatment duration, and support translation to clinical models.