Giriş ve Amaç Servikal premalign ve malign lezyonların erken tanı ve tedavisinde ve Pap (Papanicolaou) smear ve HPV tarama testlerinin önemi bilinmektedir. Bu çalışma ile üçüncü basamak tek merkez servikal tarama testi- biyopsi sonuçlarını karşılaştırmalı analiz ederek sunmayı amaçladık. Gereç ve Yöntemler Çalışmaya 3.basamak tek bir merkezde jinekolojik onkoloji polikliniğine başvuran ve kolposkopik biyopsi yapılan 272 hasta dâhil edildi. Olguların Pap smear sonuçları Betesta sistemine göre klasifiye edildi. HPV-DNA tiplendirmesi PCR yöntemi ile yapıldı. Tüm servikal biyopsi örneklerinden elde edilen H&E, p16 ve ki 67 boyalı preperatlar ışık mikroskobunda değerlendirildi. Sonuçlar istatistiksel olarak karşılaştırmalı analiz edildi. Bulgular ve sonuç HPV tarama testi, Ko-test ve Pap smear yöntemlerinin biyopsi ile uyumlarının karşılaştırılmasında HPV tarama testi anlamlı bulunmuştur (p0,05). Servikal smear testi genel topluma uygulanan bir tarama testi olup kuşkulu olgularda HPV testi yaptırmak serviks kanserini tarama açısından daha faydalı bulunmuştur.

Objectives: The aim of our study is to evaluate the tubal patency and pregnancy outcomes after tubal reanastomosis in patients who previously underwent tubal ligation but currently desire fertility. Material and methods: The study encompassed patients who underwent tubal ligation between January 2015 and November 2021 and were subsequently referred to City Hospital and University Hospital for further fertility treatment. Five patients who had undergone myomectomy with tubal re-anastomosis were excluded from the study. These patients were scheduled for hysterosalpingography (HSG) two months post-operation, and their tubal patency rates were assessed. Additionally, the pregnancy rates and outcomes were analyzed. Results: The pregnancy rate following tubal re-anastomosis was 50.2%, with a live birth rate of 44.6%. Among the patients who achieved pregnancy, 74.1% reached full term. Hysterosalpingography (HSG) revealed bilateral tubal patency in 35 patients (74.4%) and unilateral tubal patency in 12 patients (25.5%). Finally, 9 patients (15.7%) declined to undergo HSG following the procedure. Conclusions: Should the patients seeking pregnancy have normal gynecological examinations, ultrasound results, hormone profiles, comorbidity screenings, and a normal spermiogram of the husband, tubal re-anastomosis should be considered, particularly in patients under 40 years of age. Keywords: tubal reanastomosis tuboplasti seconder infertility

Objective: This study aimed to investigate the necessity and diagnostic value of endocervical curettage (ECC) in cervical preneoplastic and neoplastic lesions. Material and Methods: A total of 296 patients who were admitted to the gynecologic oncology outpatient clinic at a single tertiary care center and who simultaneously underwent colposcopic biopsy and ECC between 2018 and 2020 were included in the study. Hematoxylin-Eosin (H&E), p16, and ki-67-stained preparations obtained from biopsy and curettage samples of the patients were analyzed by light microscope. Demographic data of the patients were obtained from the hospital system. Results were statistically and comparatively analyzed. Results: Cervical premalignant/malignant lesion was detected in 125 out of 296 patients and premalignant/malignant lesion was detected in 42 patients on ECC. Out of these 42 patients, 19 were diagnosed by ECC material alone. It was striking that all of the 5 HPV-18- positive patients were diagnosed with ECC material. When conization materials of CIN 2-3 patients were assessed with ECC results, it was observed that adenocarcinoma and glandular involvement were remarkably significant in ECC-positive patients. Conclusion: Our study involves important findings in the determination of the role of ECC in diagnosing cervical premalignant lesions. ECC simultaneously performed with colposcopic biopsy for appropriate women increases the diagnosticity of colposcopic biopsy procedure and gives information about glandular involvement. Moreover, it can decrease the risk of recurrence and minimize surgical margins.

Objectives: To compare the cord blood alarin levels of infants in different birth weight groups with those of infants born to mothers diagnosed with gestational diabetes mellitus (GDM) who were not subgrouped according to birth weight. Methods: This prospective study was conducted between September 2023 and January 2024. Healthy term babies whose families agreed to participate in the study were divided into four groups according to their birth weight (small for gestational age (SGA), appropriate for gestational age (AGA) and large for gestational age (LGA)) and whether their mothers had GDM. Results: There was a significant difference between the cord blood alarin levels of the AGA and SGA groups (p=0.014). There was also a significant difference between the cord blood alarin levels of the AGA and GDM groups (p=0.012). However, the cord blood alarin levels of the LGA group (whose mothers did not have GDM) were similar to those of the AGA group (p=0.394). Conclusions: We found evidence that alarin levels in umbilical cord blood are associated with low birth weight and GDM.

İkiz Gebeliği Olan Bireylerde Anksiyete ve Depresyon Düzeyleri Öz (tr) Amaç: Bu çalışmada yardımcı üreme tekniği kullanılmadan ikiz gebeliği olan kadınlar ile tekil gebeliği olan kadınların anksiyete ve depresyon düzeylerinin karşılaştırılması amaçlanmıştır. Yöntem: Çalışmaya ikiz gebeliği olan ve 30-34 hafta arası gebeliğe sahip 36 kadın dahil edildi. Kontrol grubu olarak tekil gebeliği olan 35 kadın dahil edildi. Her iki grup ile psikiyatrist tarafından değerlendirmeleri yapılarak sosyodemografik veri formu ve Hastane Anksiyete Depresyon Ölçeği (HADS) uygulanmıştır. İkiz ve tekil gebeliği olan kadınların sosyodemografik özellikleri ve HADS skorları karşılaştırılmıştır. Bulgular: İkiz gebeliği olan kadınlar tekil gebeliği olan kadınlar ile karşılaştırıldığında yaş,eğitim durumu, çalışma durumu, ekonomik durum ve düşük öyküsü iki grup arasında anlamlı bir farklılık saptanmazken, gravida ve çocuk sayısı iki grup arasında anlamlı olarak farklıdır. HADS ölçek skorları değerlendirildiğinde ikiz gebeleri olanlarda anksiyete ve depresyon düzeyleri anlamlı olarak yüksek saptanmıştır. Sonuç: Mevcut klinik bulgular ile spontan ikiz gebeliği olan kadınlarda anksiyete ve depresyon düzeylerinin tekil gebeliğe oranla daha yüksek olduğunu saptanmıştır.