Pere Clavé

Dr. Pere Clavé

1. Gastrointestinal Physiology Laboratory, Department of Surgery, Hospital de Mataró, Consorci Sanitari del Maresme, 08304 Barcelona, Spain
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Research Focus & Metrics

Academic Career Length

35Years (1992-Present)

(Calculated once Scilit publication data is synced: current year − year of first publication + 1)

Representative Publications

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1 October 2016 in Clinical Interventions in Aging
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LBLaura Wj Baijens
Laura Wj Baijens
Pere ClavéPere Clavé
Pere Clavé
PCPatrick Cras
Patrick Cras
OEOlle Ekberg
Olle Ekberg
AFAlexandre Forster
Alexandre Forster
MWMargaret Walshe
Margaret Walshe
This position document has been developed by the Dysphagia Working Group, a committee of members from the European Society for Swallowing Disorders and the European Union Geriatric Medicine Society, and invited experts. It consists of 12 sections that cover all aspects of clinical management of oropharyngeal dysphagia (OD) related to geriatric medicine and discusses prevalence, quality of life, and legal and ethical issues, as well as health economics and social burden. OD constitutes impaired or uncomfortable transit of food or liquids from the oral cavity to the esophagus, and it is included in the World Health Organization’s classification of diseases. It can cause severe complications such as malnutrition, dehydration, respiratory infections, aspiration pneumonia, and increased readmissions, institutionalization, and morbimortality. OD is a prevalent and serious problem among all phenotypes of older patients as oropharyngeal swallow response is impaired in older people and can cause aspiration. Despite its prevalence and severity, OD is still underdiagnosed and untreated in many medical centers. There are several validated clinical and instrumental methods (videofluoroscopy and fiberoptic endoscopic evaluation of swallowing) to diagnose OD, and treatment is mainly based on compensatory measures, although new treatments to stimulate the oropharyngeal swallow response are under research. OD matches the definition of a geriatric syndrome as it is highly prevalent among older people, is caused by multiple factors, is associated with several comorbidities and poor prognosis, and needs a multidimensional approach to be treated. OD should be given more importance and attention and thus be included in all standard screening protocols, treated, and regularly monitored to prevent its main complications. More research is needed to develop and standardize new treatments and management protocols for older patients with OD, which is a challenging mission for our societies.

7 April 2015 in Nature Reviews Gastroenterology & Hepatology
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Pere ClavéPere Clavé
Pere Clavé
RSReza Shaker
Reza Shaker

1 February 2016 in Clinical Interventions in Aging
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RWRainer Wirth
Rainer Wirth
RDRainer Dziewas
Rainer Dziewas
ABAnne Marie Beck
Anne Marie Beck
Pere ClavéPere Clavé
Pere Clavé
HHHans Juergen Heppner
Hans Juergen Heppner
SHShaheen Hamdy
Shaheen Hamdy
Oropharyngeal dysphagia (OD) is a highly prevalent and growing condition in the older population. Although OD may cause very severe complications, it is often not detected, explored, and treated. Older patients are frequently unaware of their swallowing dysfunction which is one of the reasons why the consequences of OD, ie, aspiration, dehydration, and malnutrition, are regularly not attributed to dysphagia. Older patients are particularly vulnerable to dysphagia because multiple age-related changes increase the risk of dysphagia. Physicians in charge of older patients should be aware that malnutrition, dehydration, and pneumonia are frequently caused by (unrecognized) dysphagia. The diagnosis is particularly difficult in the case of silent aspiration. In addition to numerous screening tools, videofluoroscopy was the traditional gold standard of diagnosing OD. Recently, the fiberoptic endoscopic evaluation of swallowing is increasingly utilized because it has several advantages. Besides making a diagnosis, fiberoptic endoscopic evaluation of swallowing is applied to evaluate the effectiveness of therapeutic maneuvers and texture modification of food and liquids. In addition to swallowing training and nutritional interventions, newer rehabilitation approaches of stimulation techniques are showing promise and may significantly impact future treatment strategies.

26 June 2009 in Age and Ageing
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MCMateu Cabre
Mateu Cabre
MSMateu Serra-Prat
Mateu Serra-Prat
EPElisabet Palomera
Elisabet Palomera
JPJordi Almirall Pujol
Jordi Almirall Pujol
RPRoman Pallares
Roman Pallares
Pere ClavéPere Clavé
Pere Clavé
Background: oropharyngeal dysphagia is a common condition among the elderly but not systematically explored. Objective: to assess the prevalence and the prognostic significance of oropharyngeal dysphagia among elderly patients with pneumonia. Design: a prospective cohort study. Setting: an acute geriatric unit in a general hospital. Subjects: a total of 134 elderly patients (>70 years) consecutively admitted with pneumonia. Methods: clinical bedside assessment of oropharyngeal dysphagia and aspiration with the water swallow test were performed. Demographic and clinical data, Barthel Index, Mini Nutritional Assessment, Charlson Comorbidity Index, Fine's Pneumonia Severity Index and mortality at 30 days and 1 year after admission were registered. Results: of the 134 patients, 53% were over 84 years and 55% presented clinical signs of oropharyngeal dysphagia; the mean Barthel score was 61 points indicating a frail population. Patients with dysphagia were older, showed lower functional status, higher prevalence of malnutrition and comorbidities and higher Fine's pneumonia severity scores. They had a higher mortality at 30 days (22.9% vs. 8.3%, P = 0.033) and at 1 year of follow-up (55.4% vs. 26.7%, P = 0.001). Conclusions: oropharyngeal dysphagia is a highly prevalent clinical finding in elderly patients with pneumonia and is an indicator of disease severity in older patients with pneumonia.

1 December 2008 in Clinical Nutrition
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Pere ClavéPere Clavé
Pere Clavé
VAViridiana Arreola
Viridiana Arreola
MRMaise Romea
Maise Romea
LMLucía Medina
Lucía Medina
EPElisabet Palomera
Elisabet Palomera
MSMateu Serra-Prat
Mateu Serra-Prat

16 October 2006 in Alimentary Pharmacology & Therapeutics
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Pere ClavéPere Clavé
Pere Clavé
MKM. DE Kraa
M. DE Kraa
VAV. Arreola
V. Arreola
MGM. Girvent
M. Girvent
RFRicard Farre
Ricard Farre
MSMateu Serra-Prat
Mateu Serra-Prat
Summary: Aim: To assess the pathophysiology and treatment of neurogenic dysphagia.Methods: 46 patients with brain damage, 46 with neurodegenerative diseases and eight healthy volunteers were studied by videofluoroscopy while swallowing 3–20 mL liquid (20.4 mPa s), nectar (274.4 mPa s) and pudding (3931.2 mPa s) boluses.Results: Volunteers presented a safe and efficacious swallow, short swallow response (≤740 ms), fast laryngeal closure (≤160 ms) and strong bolus propulsion (≥0.33 mJ). Brain damage patients presented: (i) 21.6% aspiration of liquids, reduced by nectar (10.5%) and pudding (5.3%) viscosity (P < 0.05) and (ii) 39.5% oropharyngeal residue. Neurodegenerative patients presented: (i) 16.2% aspiration of liquids, reduced by nectar (8.3%) and pudding (2.9%) viscosity (P < 0.05) and (ii) 44.4% oropharyngeal residue. Both group of patients presented prolonged swallow response (≥806 ms) with a delay in laryngeal closure (≥245 ms), and weak bolus propulsion forces (≤0.20 mJ). Increasing viscosity did not affect timing of swallow response or bolus kinetic energy.Conclusions: Patients with neurogenic dysphagia presented high prevalence of videofluoroscopic signs of impaired safety and efficacy of swallow, and were at high risk of respiratory and nutritional complications. Impaired safety is associated with slow oropharyngeal reconfiguration and impaired efficacy with low bolus propulsion. Increasing bolus viscosity greatly improves swallowing function in neurological patients.