The main objective of this research is to describe a multidisciplinary investigation part of an ongoing research project. The contribution focuses on the identification and selection of innovative technologies and operative methodologies capable of fostering the sustainable innovation and resilience of the Italian N-E territory by addressing four challenges: energy transition, environmental challenges, adaptation to climate change, and digitalisation. The investigation devised an original conceptual research framework aiming to identify possible solutions and drawing a connection between them and the challenges, by considering the actions, the technological and methodological support, and, indirectly, the European and global policy objectives they help to reach. The research results are: (i) a definition of the four challenges in light of the built environment and construction sector; (ii) the conceptual research framework schema as a replicable instrument; (iii) its contextualization to the research scope; (iv) a preliminary list of technologies and methodologies supporting the sustainable innovation in the given territorial context; and (v) a ranking of the most promising solutions according to their effectiveness and application potential. The results highlight how, in the Italian N-E context, the solutions most effective in delivering sustainability and resilience are the ones operating in the built environment by preserving the built resources, mainly by addressing the building envelope and structure.

The COVID-19 spread abruptly changed the fruition of indoor environments, where necessary adaptive measures have since been implemented. Buildings open to the public were suddenly equipped with physical devices aiming to encourage users’ appropriate behaviors, such as hand sanitizing, social distancing, and temperature monitoring. Through a twofold architectural-psychological perspective, the paper presents a research aiming to understand how users perceive these devices in the Italian context and to identify the design features that could improve their effectiveness in enhancing individuals’ awareness. With an interdisciplinary approach, four methods were adopted: observational field surveys, background and normative framework analysis, survey research through an online questionnaire, and case studies survey research. The results confirm the overall effectiveness of the implemented anti-COVID strategies, their suitability in encouraging individuals’ appropriate behaviors, and the importance of regulating the users’ flow indoors. The research allowed defining the devices (hand-sanitizing devices and temperature-measurement instruments) and wayfinding systems more suited to be included in the prevention strategy and identified their more appropriate design features in relation to the users’ feedback. Operational suggestions are presented as well. The adopted experimental approach can be useful in supporting decision making in managing of the built environment in both the current and future contexts.