Sarcoidosis is a chronic multisystemic inflammatory disease of unknown etiology, often associated with pulmonary involvement and characterized histopathologically by non-caseating granulomatous lesions. In this report, we aimed to present a 32-year-old patient who was hospitalized with a pre-diagnosis of cellulite, diagnosed with sarcoidosis based on skin lesions, and whose symptoms completely regressed with sarcoidosis treatment.

Aims: This study explored how anxiety, depression, trauma-related stress, quality of life (QoL) and information-seeking habits changed among residents of a nursing home during the early months of the COVID-19 pandemic. The first evaluation was carried out at the very beginning of the pandemic, a time when no infections had yet been detected in the facility. The second assessment took place five months later, after the first confirmed case had occurred inside the nursing home. Methods: The same group of residents was assessed twice, following a repeated-measures comparative approach. This study was conducted in a municipal nursing home, and evaluations were performed at two distinct time points. The first assessment took place in March 2020, shortly after national restriction measures were introduced and before any COVID-19 cases had occurred within the facility. The second assessment was conducted in the following months after the first in-house transmission, reflecting the early progression of the pandemic within the institutional setting. Psychological status was measured using the Geriatric Depression Scale (GDS), Geriatric Anxiety Scale (GAS), Impact of Events Scale (IES), Coronavirus Anxiety Scale (CAS), and EQ-5D, all administered face-to-face to eligible participants. Results: Across the five-month interval, there was a marked rise in anxiety and trauma-related stress (GAS increased from 3 to 12, p

Objectives: Inappropriate medication use is highly prevalent in nursing home residents and contributes to adverse drug events, falls, and increased healthcare utilization. The Turkish Inappropriate Medication use in oldEr adults (TIME) criteria provide a comprehensive framework for identifying both potentially inappropriate medications and prescribing omissions. We aimed to evaluate the outcomes of a Medication Therapy Management (MTM) intervention by use of TIME criteria among nursing home residents in Türkiye. Methods: This single-arm before–after observational study included 232 adults aged 60–110 years residing in the Bursa Metropolitan Municipality Nursing Home. Medication use patterns were evaluated using the TIME criteria and prescriptions were optimized through a Medication Therapy Management (MTM) intervention. Fall frequency and healthcare utilization outcomes were recorded during the 1 year before and after MTM implementation. Results: Following implementation of the Medication Therapy Management (MTM) approach based on TIME criteria, the median number of medications increased from 5 (IQR: 3–8) to 8 (IQR: 5–10) over one year (p < 0.001). During the post-implementation period, fall frequency, emergency department visits, family medicine visits, and non-geriatric specialist visits were lower compared with the pre-intervention year, whereas hospitalization rates did not significantly change. Conclusions: Among nursing home residents, the total number of medications was higher and fall frequency and selected healthcare utilization measures were lower during the year following implementation of MTM based on TIME criteria. These findings suggest that MTM-guided prescription optimization may be associated with changes in clinical and healthcare utilization outcomes; however, the absence of a control group precludes causal inference, and randomized controlled trials are required to confirm these associations.

To evaluate whether sodium-glucose cotransporter-2 (SGLT2) inhibitor use is associated with osteoporosis and dual-energy X-ray absorptiometry (DEXA)-derive

The aim of this study is to investigate the differences between males and females in clinical findings, hereditary characteristics, treatment responses and pathogen Mediterranean fever (MEFV) gene phenotype frequencies in FMF patients. The data of 105 patients (70 females, 35 males) whose charts were available for all research data were evaluated. While evaluating the clinical findings; The age of attack onset, attack character, dominant attack location, presence of recurrent fever, appendectomy history and family history were evaluated. the response to colchicine treatment was questioned. The phenotype frequencies of the pathogen variations in the MEFV gene were determined. The frequency of individuals with typical attack character was 71.4% in women and 82.9% in men. The frequency of the predominant attack localization with peritoneum was 90% in women and 88.6% in men. The proportion of those with colchicine response was 92.8% and 85.7% in women and men, respectively. The phenotype frequencies of pathogen MEFV gene mutations were 62.7% and 88.6% for M694V (p=0.006), 22.4% and 14.3% (p=0.328) for V726A, 20.9% for M680I in women and men, respectively, and 22.9% (p = 0.819) and 14.9% and 14.3% (p=0.931) for E148Q. Clinical findings and treatment responses are not different in individuals with FMF disease. The frequency of the M694Vmutation, which has high penetration and is associated with important complications such as amyloidosis, is higher in men. There is a need for studies to evaluate FMF activity according to gender distribution.