Margarita Diaz Martinez

Dr. Margarita Diaz Martinez

orcid

Research Focus & Metrics

Academic Career Length

9Years (2018-Present)

(Calculated once Scilit publication data is synced: current year − year of first publication + 1)

Representative Publications

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18 September 2018 in Molecules
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Journal Article
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Claudia Delgadillo PugaClaudia Delgadillo Puga
Claudia Delgadillo Puga
Mario Cuchillo-HilarioMario Cuchillo-Hilario
Mario Cuchillo-Hilario
ANArturo Navarro
Arturo Navarro
OMOmar Noel Medina-Campos
Omar Noel Medina-Campos
ACAntonio Nieto Camacho
Antonio Nieto Camacho
José Pedraza-ChaverriJosé Pedraza-Chaverri
José Pedraza-Chaverri
Background: Acacia farnesiana (AF) pods have been traditionally used to treat dyspepsia, diarrhea and topically for dermal inflammation. Main objectives: (1) investigate the antioxidant activity and protection against oxidative-induced damage of six extracts from AF pods and (2) their capacity to curb the inflammation process as well as to down-regulate the pro-inflammatory mediators. Methods: Five organic extracts (chloroformic, hexanic, ketonic, methanolic, methanolic:aqueous and one aqueous extract) were obtained and analyzed by UPLC-ESI-Q-oa/TOF-MS. Antioxidant activity (DPPH•, ORAC and FRAP assays) and lipid peroxidation (TBARS assay) were performed. Assessment of anti-inflammatory properties was made by the ear edema induced model in CD-1 mice and MPO activity assay. Likewise, histological analysis, IL-1β, IL-6, IL-10, TNF-α, COX measurements plus nitrite and immunohistochemistry analysis were carried out. Results: Methyl gallate, gallic acid, galloyl glucose isomer 1, galloyl glucose isomer 2, galloyl glucose isomer 3, digalloyl glucose isomer 1, digalloyl glucose isomer 2, digalloyl glucose isomer 3, digalloyl glucose isomer 4, hydroxytyrosol acetate, quinic acid, and caffeoylmalic acid were identified. Both organic and aqueous extracts displayed antioxidant activity. All extracts exhibited a positive effect on the interleukins, COX and immunohistochemistry assays. Conclusion: All AF pod extracts can be effective as antioxidant and topical anti-inflammatory agents.

13 September 2024 in Metabolites
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Journal Article
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Mario Cuchillo-HilarioMario Cuchillo-Hilario
Mario Cuchillo-Hilario
MFMareli Itzel Fournier
Mareli Itzel Fournier
MMMargarita Diaz Martinez
Margarita Diaz Martinez
SBSara Montaño Benavides
Sara Montaño Benavides
MCMaría de la Concepción Calvo
María de la Concepción Calvo
Claudia Delgadillo PugaClaudia Delgadillo Puga
Claudia Delgadillo Puga
Recent attention has been given to animal feeding and its impact on human nutrition. Animal feeding is essential for meeting human dietary needs, making it a subject of significant interest and investigation. This review seeks to outline the current understanding of this disciplinary area, with a focus on key research areas and their potential implications. The initial part of the paper discusses the importance of animal feed resources and recognizes their crucial role in guaranteeing sufficient nutrition for both humans and animals. Furthermore, we analyzed the categorization of animal feeds based on the guidelines established by the National Research Council. This approach offers a valuable structure for comprehending and classifying diverse types of animal feed. Through an examination of this classification, we gain an understanding of the composition and nutritional content of various feedstuffs. We discuss the major categories of metabolites found in animal feed and their impact on animal nutrition, as well as their potential health advantages for humans. Flavonoids, polyphenols, tannins, terpenoids, vitamins, antioxidants, alkaloids, and essential oils are the primary focus of the examination. Moreover, we analyzed their possible transference into animal products, and later we observed their occurrence in foods from animal sources. Finally, we discuss their potential to promote human health. This review offers an understanding of the connections among the major metabolites found in feedstuffs, their occurrence in animal products, and their possible impact on the health of both animals and humans.

19 April 2022 in Anales de Psicología
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MÁMarsela Alejandra Álvarez-Izazaga
Marsela Alejandra Álvarez-Izazaga
CGCarlos Galindo Gómez
Carlos Galindo Gómez
JRJosé Antonio Roldán-Amaro
José Antonio Roldán-Amaro
GSGabriel Saucedo-Arteaga
Gabriel Saucedo-Arteaga
MMMargarita Diaz Martinez
Margarita Diaz Martinez
Mario Cuchillo-HilarioMario Cuchillo-Hilario
Mario Cuchillo-Hilario
El objetivo de este estudio fue comparar características generales y de atención en salud entre menores y sus madres migrantes y no migrantes en indígenas Tarahumaras, en Chihuahua, México. Así mismo, se evaluó la asociación entre el riesgo de retraso en neurodesarrollo en niños y las prácticas de estimulación oportuna. Niños y niñas de entre 12 a 48 meses de edad fueron estudiados en dos grupos: 1) menores de madres migrantes ubicados en asentamientos urbanos en la ciudad de Chihuahua y 2) menores de madres no migrantes residentes en sus localidades de origen. La prevalencia de riesgo de retraso del neurodesarrollo moderado y grave (RNMG) fue mayor en menores de madres migrantes versus no migrantes (75.6%, IC95% [69.5, 80.8] vs 59.8%, [51.4, 67.7], p = .003). La proporción de niños(as) que recibieron una estimulación oportuna favorable (EOF) en casa fue mayor en los menores de madres no migrantes (p < .001). La migración de las madres indígenas hacia asentamientos urbanos estuvo asociada al RNMG en sus hijos(as) (p = .03), así como las prácticas insuficientes de estimulación oportuna (p = .03). La asistencia consistente a sesiones de estimulación temprana del programa de Educación Inicial fue mayor en niños(as) de madres no migrantes (p = .01); y la no asistencia fue predictor del RNMG (p = .02).

2 January 2025 in Abanico Veterinario
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Journal Article
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Mario Cuchillo-HilarioMario Cuchillo-Hilario
Mario Cuchillo-Hilario
MMMargarita Diaz Martinez
Margarita Diaz Martinez
CÁConsuelo Álvarez-Rodríguez
Consuelo Álvarez-Rodríguez
LMLuis López Morales
Luis López Morales
Claudia Delgadillo PugaClaudia Delgadillo Puga
Claudia Delgadillo Puga
Thermoregulation in homeothermic animals is an active and continuous physiological process that balances heat generation (thermogenesis) and heat loss (thermolysis) to maintain thermal homeostasis, which is crucial in the face of climate change. Homeothermic animals regulate their body temperature (37–42°C) through neural and peripheral mechanisms, with the preoptic area of the hypothalamus acting as a key integrating nucleus, although evidence suggests the existence of decentralized hypothalamic-associated networks that play complementary roles. Strategies to maintain homeostasis in cold conditions include cutaneous vasoconstriction, non-shivering thermogenesis (brown adipose tissue activity), and skeletal muscle contraction to conserve body heat. In contrast, heat induces capillary vasodilation, sweating, and panting to facilitate thermolysis or heat loss. Transient receptor potential (TRP) channels and GABAergic/glutamatergic neurons modulate these responses, with direct implications for hyperthermia/hypothermia processes. The physiological asymmetry between the upper and lower limits of thermal homeostasis highlights the vulnerability of organisms to extreme temperatures outside their comfort zone. http://dx.doi.org/10.21929/abavet2025.13 e2025-34 https://www.youtube.com/watch?v=Hvh8qP8FHJc La termorregulación en animales homeotermos es un proceso fisiológico activo y permanente que equilibra la generación (termogénesis) y la pérdida (termólisis) de calor para mantener una homeostasis térmica, crucial ante el cambio climático. Los animales homeotermos regulan su temperatura corporal (37 - 42°C) mediante mecanismos neurales y periféricos, donde en especial la zona preóptica del hipotálamo, actúa como un núcleo integrador, aunque hay evidencia de la existencia de redes descentralizadas asociadas al hipotálamo que son complementarias. Existen estrategias para mantener la homeostasis ante el frío como la vasoconstricción cutánea, la termogénesis no tiritante (actividad del tejido adiposo pardo) y la contracción muscular esquelética con el fin de conservar el calor corporal. En contraste, el calor induce una vasodilatación capilar, sudoración y jadeo para facilitar la termólisis o pérdida de calor. Los canales de potencial receptor transitorio y las neuronas GABAérgicas/glutamatérgicas modulan estas respuestas, con implicaciones directas en los procesos de hipertermia/hipotermia. La asimetría fisiológica entre límites superiores e inferiores de la homeostasis térmica, hace evidente la vulnerabilidad de los organismos a las temperaturas extremas fuera de la zona de confort. http://dx.doi.org/10.21929/abavet2025.13 e2025-34 https://www.youtube.com/watch?v=Hvh8qP8FHJc http://dx.doi.org/10.21929/abavet2025.13 e2025-34 https://www.youtube.com/watch?v=Hvh8qP8FHJc

6 October 2026 in Journal of Experimental Zoology Part A: Ecological and Integrative Physiology
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Journal Article
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Mario Cuchillo-HilarioMario Cuchillo-Hilario
Mario Cuchillo-Hilario
MMMargarita Diaz Martinez
Margarita Diaz Martinez
MVMario Alberto Viazcan‐Carbajal
Mario Alberto Viazcan‐Carbajal
VGVictor David González‐Fernández
Victor David González‐Fernández
The enteric nervous system (ENS) constitutes the largest and most functionally autonomous subdivision of the peripheral nervous system in vertebrates. It orchestrates stereotyped motor programs, secretomotor reflexes, and neuroimmune responses without central input. This review synthesizes evidence from developmental biology, mucosal immunology, and comparative physiology to advance a framework of enteric allostatic plasticity: the proposition that ENS functional resilience arises not from hard‐wired reflex arcs but from a conserved capacity for transcriptional and morphological remodeling instructed by the local immune and microbial environment. We first examine the developmental ontogeny of enteric neurons, emphasizing vagal and sacral neural crest contributions, the GDNF‐RET chemotactic axis governing colonization, and the hierarchical transcriptional cascades (PHOX2B, ASCL1, HAND2) that specify cholinergic, nitrergic, and serotonergic lineages. We next dissect the molecular architecture of the mature ENS, systematizing neurochemical coding, re‐evaluating enteric glial heterogeneity across selected animal species, and describing structural variations in ganglionated plexuses that reflect evolutionary scaling of the gut wall. Functional circuit analysis addresses intrinsic sensory transduction via IPANs and enterochromaffin cells, the coordination of peristaltic and segmental motor patterns, and the neuroimmune circuits linking enteric neurons to muscularis macrophages and the innate lymphoid cells. Finally, we position the ENS as a central hub within bidirectional gut‐brain and gut‐immune axes, integrating microbial metabolites, stress hormones, and inflammatory signals to maintain intestinal allostasis. A comparative approach, contrasting murine, porcine, zebrafish, and human systems, is a prerequisite for distinguishing fundamental design principles from lineage‐specific elaborations and for translating mechanistic insights to clinical and veterinary neurogastroenterology.

13 October 2025 in Horizonte Académico
Verified
Journal Article
Closed access
GHGerardo Juan Rodríguez Hernández
Gerardo Juan Rodríguez Hernández
JSJosé Ángel Ledesma Solano
José Ángel Ledesma Solano
MMMargarita Diaz Martinez
Margarita Diaz Martinez
Objetivo: Conocer cuántos trabajadores de un Instituto Nacional de Salud utilizan sus teléfonos móviles, qué redes sociales manejan y cuáles prefieren, así como saber qué información buscan en internet. Método: Estudio observacional, transversal y descriptivo, con una muestra por conveniencia. Se aplicó una encuesta anónima a distancia, auto aplicada y que se responde vía teléfono celular, dirigida a toda aquella persona trabajadora del Instituto que usa teléfono celular y accede a redes sociales. Resultados: La encuesta contó con la participación de 227 trabajadores del Instituto, entre 18 a 69 años de edad de diversas áreas, encuesta descriptiva y exploratoria de una sola aplicación. La mayoría cuenta con estudios de nivel superior, accede a redes sociales utilizando su celular y está familiarizado con los códigos de respuesta rápida (QR). La red social más utilizada es Facebook, con variantes de acuerdo a la edad. El 59.9 % prefiere acceder a la información mediante eventos diferidos. Conclusiones: Existe una gran afinidad por Facebook, lo que sugiere que esta red puede ser una opción viable para transmitir al personal del Instituto de Salud información basada en evidencia sobre salud, alimentación y nutrición. Las encuestas en línea son una herramienta conveniente para recopilar información.