Auditory evoked potentials (AEPs) are brain-derived electrical signals, following an auditory stimulus, utilised to examine any obstructions along the brain neural-pathways and to diagnose hearing impairment. The clinical evaluation of AEPs is based on the measurements of the latencies and amplitudes of waves of interest; hence, their identification is a prerequisite for AEP analysis. This process has proven to be complex, as it requires relevant clinical experience, and the existing software for this purpose has little practical use. The aim of this study was the development of two automated annotation tools for ABR (auditory brainstem response)- and AMLR (auditory middle latency response)-tests. After the acquisition of 1046 raw waveforms, appropriate pre-processing and implementation of a four-stage development process were performed, to define the appropriate logical conditions and steps for each algorithm. The tools’ detection and annotation results, regarding the waves of interest, were then compared to the clinicians’ manual annotation, achieving match rates of at least 93.86%, 98.51%, and 91.51% respectively, for the three ABR-waves of interest, and 93.21%, 92.25%, 83.35%, and 79.27%, respectively, for the four AMLR-waves. The application of such tools in AEP analysis is expected to assist towards an easier interpretation of these signals.

This poster presents a comprehensive assessment of the transformative potential of telehealth ecosystems, integrating Internet of Things (IoT), Internet of Medical Things (IoMT), and Artificial Intelligence (AI) technologies. The study explores their impact on healthcare delivery and markets, emphasising the need for robust cybersecurity measures and technological integration. By facilitating continuous monitoring, personalised interventions, and improved patient outcomes, the integration of advanced technologies in telehealth ecosystems has the potential to revolutionise healthcare delivery and reduce healthcare costs. However, successful implementation and maximisation of their benefits require collaborative research and adherence to ethical and regulatory standards.

Heart failure management increasingly relies on heterogeneous clinical and real-world data generated through remote monitoring technologies. However, transforming these multimodal data streams into actionable insights requires robust interoperability infrastructures. This study presents the RETENTION interoperability framework, a federated HL7 Fast Healthcare Interoperability Resources (FHIR)-based architecture designed to support multi-site heart failure monitoring across five independent clinical environments. A semantic reference model comprising 444 clinical and contextual variables was developed and aligned with FHIR R4 resources and internationally recognised terminology systems. The platform adopts a selective profiling strategy, extending only the Patient resource while standardising the remaining variables through example-driven Implementation Guide documentation. Identifiable data are retained locally within Clinical Site Backends, whereas anonymised datasets are periodically aggregated into a Global Insights Cloud to enable centralised analytics and controlled third-party interactions. The framework was deployed across six hospitals (with two Spanish hospitals sharing the same deployment), supporting 390 patients and over 130,000 patient-days of monitoring, with more than 3.6 million remote device data points harmonised without schema conflicts. The results demonstrate that large-scale semantic harmonisation and privacy-preserving aggregation can be achieved using a lightweight profiling approach, providing a scalable and reproducible interoperability model for multi-centre digital health research infrastructures.

Background/Objective: Predictive models for cardiovascular disease rely predominantly on electronic health records (EHRs), whereas wearable devices, home monitoring, and patient-reported outcomes offer new opportunities for multimodal risk prediction; however, integrating these heterogeneous sources into a reproducible, clinically usable machine learning workflow remains challenging. This study aimed to develop an end-to-end architecture for explainable multimodal time-series prediction in patients with heart failure (HF), left ventricular assist device (LVAD) recipients, and heart transplant (HT) recipients. Methods: The modular architecture harmonizes Health Level Seven Fast Healthcare Interoperability Resources (HL7 FHIR) and non-FHIR telemonitoring data into a unified event log, which leakage-aware temporal preprocessing converts into patient-day feature matrices. Configurable adverse-event tasks (HF hospitalization, cardiac decompensation, transplant rejection, and mortality) are modeled using gradient-boosted trees or temporal neural networks, with optional probability calibration. Explanations combine SHapley Additive exPlanations (SHAP) for tabular models with temporal-perturbation attribution and integrated gradients for sequence models. The pipeline is declaratively configured, tracked with MLflow, and deployable via command-line and web interfaces. It was developed alongside the prospective multicenter RETENTION trial of a telemonitoring-based care pathway and was subsequently applied to data collected within the trial. Results: Applied to the RETENTION cohort, the framework executed the complete workflow, from heterogeneous source data to per-patient-day probability estimates for each prediction task, with feature- and time-level explanations presented as clinician-facing narratives. The cohort served to demonstrate the architecture, not to establish clinical predictive performance or prospective clinical validation. Conclusions: This study provides a reproducible, end-to-end architecture that unifies data harmonization, temporal processing, machine learning orchestration, explainability, and deployment for multimodal clinical prediction. Its modular, disease-agnostic design supports adaptation to other diseases, settings, and data sources, laying a foundation for prospective validation and clinical translation.

Digital health solutions increasingly rely on interoperable software platforms that integrate heterogeneous data sources, support remote patient monitoring and deliver clinical decision support while complying with strict security, privacy and regulatory requirements. Numerous studies report the clinical outcomes or analytical capabilities of such systems. However, the engineering processes leading to their development are rarely described in a systematic manner. This paper presents the design, development, integration and technical validation of the RETENTION digital health platform for the remote monitoring and management of advanced heart failure patients. The platform was developed as a modular software ecosystem integrating mobile and web applications, medical devices, clinical and real-world data repositories, and artificial intelligence services through an HL7 FHIR-centred architecture. The complete engineering lifecycle, from requirements and architecture to software development, integration and validation, is described in this paper. Emphasis is placed on the adoption of interoperability standards, Security and Privacy by Design principles, data management mechanisms and deployment strategies that enable the integration of heterogeneous technologies into a unified platform. By documenting the complete development pathway, this work aims to serve as a guide for the design and implementation of large-scale digital health platforms that support remote patient monitoring and chronic disease management.