As a prominent frontier in ultrafast laser–matter interaction, femtosecond laser filamentation holds great potential for atmospheric pollutant detection and remote sensing. However, its practical application in the open atmosphere is severely hampered by atmospheric turbulence, which induces beam wander, wavefront distortion, and intensity scintillations. In this study, we numerically investigated the propagation dynamics of femtosecond laser filaments in a turbulent medium and elucidated the underlying physical mechanisms. The results show that, compared to linear propagation, the nonlinear self-guiding effect inherent to filamentation effectively suppresses turbulence-induced beam wander. Furthermore, by employing vortex beams carrying orbital angular momentum (OAM), we significantly suppressed the stochastic generation of multiple filaments, thereby notably improving the stability of long-range filament propagation in complex atmospheric conditions. These findings provide new insights into the physical mechanisms and novel strategies for improving the robustness of laser filamentation technology in real-world turbulent environments.