Mixed incineration of municipal solid waste (MSW) in existing coal gangue power plant is a potentially high-efficiency and low-cost MSW disposal way. In this paper, the co-combustion and pollutants emission characteristic of MSW and coal gangue was investigated in a circulating fluidized bed (CFB) combustor. The effect of MSW blend ratio, bed temperature and excess air ratio was detailedly studied. The results show the NO_x and HCl emission increases with the increasing MSW blend ratio and the SO₂ emission decreases. With the increase of bed temperature, the CO emission decreases while the NO_x and SO₂ emission increases. The HCl emission is nearly stable in the temperature range of 850–950 °C. The increase of excess air ratio gradually increases the NO_x emission but has no significant effect on the SO₂ emission. The HCl emission firstly increases and then decreases with the increase of excess air ratio. For a typical CFB operating condition with excess air ratio of 1.4, bed temperature of 900 °C and MSW blend ratio of 10%, the original CO, NO_x, SO₂ and HCl emissions are 52, 181, 3373 and 58 mg/N m³ respectively.