BACKGROUND: Periodontal disease has been and will be a challenge for dentists in the entirety of oral pathologies. To date, there is no data regarding the prescription of antibiotics for periodontitis in the district of Tirana.AIM: Evaluate aspects related to the pattern of prescription of antibiotics among dentists in Tirana region for periodontitis.METHODS: Prescriptions from dental practitioners were collected from 25 pharmacies, randomly selected. The only prescription containing a diagnosis of periodontitis, with at least one antibiotic given, was included in the study. Data analysis was done with SPSS 20.RESULTS: Out of 1159 initial prescriptions, only 314 met the selection criteria. The average age of patients was 39.91 ± 15.21 years. Mean duration of therapies was 5.57 ± 1.5 days. The most common form of prescription was one broad-spectrum antibiotic (74.5%), combined antibiotics therapy (22.3%) and narrow-spectrum antibiotic (3.2%). Combined antibiotics involved the use of Metronidazole with Amoxicillin (12.1%) and Metronidazole with Spiramycin (10.2%). Significant differences in the patterns of prescription were identified in relation with patient age and therapy duration (P < 0.05). No statistical difference was found in the patient’s gender and the typology of the therapy (P > 0.05).CONCLUSIONS: Our study shows prescription characteristics of antibiotics for periodontal disease by dentists in Tirana for the first time. Amoxycillin is the most prescribed antibiotic, followed by amoxicillin with clavulanic acid. We found variation in dosage, frequency and duration for all antibiotics used, and perceptible discrepancies between observed and recommended practice. Guidelines on rational antibiotic use are needed for dental practitioners in Tirana and the Republic of Albania for better management of periodontitis and resistance prevention.

Background: Type 2 diabetes mellitus (T2DM) and periodontitis are chronic inflammatory conditions. Periodontitis may amplify low-grade systemic inflammation in people with T2DM. High-sensitivity C-reactive protein (hsCRP) reflects this inflammatory burden, but the effect of non-surgical periodontal therapy (NSPT) on hsCRP in T2DM remains uncertain. Objective: To evaluate whether NSPT changes hsCRP at 3 and 6 months compared with oral hygiene instructions alone in patients with T2DM and periodontitis. Methods: Predefined secondary analysis of a 1:1 parallel-group randomized trial with assessments at baseline, 3 months, and 6 months. Participants received scaling and root planing plus oral hygiene instructions (intervention) or oral hygiene instructions only (control). Fasting hsCRP (mg/L) was analyzed on the log scale using mixed-effects models; effects are presented as exponentiated ratios with 95% confidence intervals. Sensitivity analyses included baseline-adjusted analysis of covariance (ANCOVA) and covariate-adjusted mixed models. An exploratory group-adjusted regression examined associations between periodontal changes and hsCRP change. Results: Eighty-nine participants were randomized (45 control, 44 intervention), with hsCRP available for most participants through 6 months. There was no between-group difference at 3 months (ratio 0.958; 95% CI 0.875–1.049; p = 0.358). At 6 months, hsCRP was lower in the NSPT group than in controls (ratio 0.809; 95% CI 0.738–0.887; p < 0.001), corresponding to ~19% lower hsCRP; the model-based geometric mean hsCRP at 6 months was 2.66 mg/L versus 3.26 mg/L. Periodontal measures improved more with NSPT, but changes in periodontal measures were not independently associated with hsCRP change after group adjustment. Conclusions: In patients with T2DM and periodontitis, NSPT was associated with lower hsCRP at 6 months compared with oral hygiene instructions alone. These biomarker findings suggest a potential systemic anti-inflammatory effect, but should be interpreted as hypothesis-generating and confirmed in adequately powered trials.