Objective: To investigate the effect of silent information regulator 1 (SIRT1) gene polymorphisms on ambulatory blood pressure in hypertensive patients. Methods: Three hundred forty hypertensive patients were recruited from January 2013 to January 2015. SIRT1 Tag single-nucleotide polymorphisms (SNPs; rs2273773, rs4746720, and rs7896005) were genotyped using a PCR-direct sequencing method, and the association between the SIRT1 gene SNPs and ambulatory blood pressure was analyzed. Results: After adjusting for confounding factors, patients with the rs2273773/CT+CC genotypes had lower 24-h systolic and diastolic blood pressures; there were no associations between rs4746720 and rs7896005 genotypes and blood pressure. Conclusion: The SIRT1 gene polymorphism (rs2273773) is significantly associated with ambulatory blood pressure level in Han Chinese patients with hypertension.

Key Clinical Message: For psoriatic patients who develop bullous pemphigoid, a rare yet serious complication, prompt initiation of combined glucocorticoid and methotrexate provides rapid disease control and sustained remission. This regimen serves as an effective steroid‐sparing strategy, though long‐term monitoring remains essential to manage recurrence risks during steroid taper.

This case report describes a 28-year-old healthy male who developed high-altitude pulmonary edema (HAPE) after a rapid ascent. While his condition improved with standard therapy (including corticosteroids, diuretics, and supplemental oxygen), he developed symptomatic sinus bradycardia (heart rate nadir: 37 bpm) 2 days after discontinuation of these medications. The bradycardia resolved with intravenous potassium supplementation and fluid resuscitation, and his heart rate recovered to 59 bpm. This case highlights that a rebound in vagal tone and steroid withdrawal may contribute to severe bradycardia during the HAPE recovery phase, warranting heightened clinical vigilance.