Wound healing is a complex, multi-stage process governed by tightly regulated molecular mechanisms. However, effective regenerative therapies remain with limitations. This study presents a novel marine-derived biocomposite, JPC-ALG-CT, designed to improve wound healing through synergistic bioactive mechanisms. The material incorporates collagen extracted from the jellyfish Rhizostoma pulmo, chitosan derived from the crab Pachygrapsus mormoratus, and polysaccharide-rich extracts from the green alga Cladophora vagabunda, all sourced from the Black Sea. The study is based on the biochemical analysis of these three marine-derived components, highlighting the collagen content of jellyfish, the polysaccharides present in algae, and the bioactive properties of chitosan. The biochemical and physico-chemical properties of each component were characterized, with particular emphasis on the structural features of jellyfish collagen and the functional bioactivity of chitosan and algal polysaccharides. The research findings are supported by the identification of the collagen type extracted from jellyfish, as well as by the characterization of chitosan and green algal extracts. The resulting composite demonstrated significant antioxidant and antimicrobial activities, indicating its potential to integrate key processes involved in wound repair, including inflammation control and microbial protection. In vitro studies using fibroblast and keratinocyte models showed that the JPC-CT-ALG biocomposite supported cell viability at lower tested concentrations and promoted scratch closure in cell monolayers, suggesting preliminary wound-relevant biological activity. These findings suggest that the combined marine-derived components interact to enchance wound healing at the cellular level. This work evidenced the potential of marine biomaterials as sources for next-generation regenerative therapies and supports further investigation into their molecular mechanisms and in vivo applications for improved wound care.

Pigment disorders of both aging skin and retina involve many common mechanisms. A better understanding of such mechanisms might lead to effective prevention and noninvasive therapy strategies applicable to both locations of pigmentary disorders. The direct consequence of such pigmentary disorders involving the retinal tissue generates age-related macular degeneration (AMD), the leading cause of vision loss in the elderly, which occurs as a progressive loss of macular pigments. Oxidative stress on retinal pigment is nowadays exacerbated by environmental factors such as chronic ultraviolet (UV) exposure, pollution, toxic heavy metal accumulation, and amplified by climate change. Increased risks of damaging effects urge proactive preventive strategies and therapies. Nutritional antioxidant supplementation has emerged as a key preventive approach. Clinical studies in AMD patients indicate that long-term Xanthophyll carotenoid supplementation can slow the progression of degeneration and vision loss. Beyond these, a variety of plant-derived supplements have demonstrated significant in vitro/in vivo antioxidative activity, with protective anti-aging effects. This comprehensive paradigm, linking antioxidative nutrition, environmental risk mitigation, and medical therapies, exemplifies a modern translational strategy to reduce oxidative damage and improve outcomes in retinal aging pigment disorders.

The present study investigated the influence of quercetol upon δ-aminolevulinic acid (△ -ALA) urine concentration as marker of lead poisoning. The study was conducted on six lots of 6 mature Wistar rats of both sexes, lots not poisoned treated with different concentrations of quercetol (Q1, Q2), control (L6M), lot poisoned untreated (L3Pb), lots poisoned and treated with Q (L4Q1Pb and L5Q2Pb). After 11 days urine from 24 hours was collected for △-ALA spectrophotometric assay and testing the significance of mean difference of by "t" test Student at p

The aim of this paper is the valorization of a 10 % anthocyanins elderberries lyophilized extract standardized as cyanidin-3-glucoside in lozenges obtained by direct compression and quality lozenges evaluation according to Romanian and European pharmacopoeia tests. The resulting lozenges with a 600 mg concentration of a 10 % anthocyanins elderberries lyophilized extract standardized as cyanidin-3-glucoside were evaluated using the following tests: appearance and mass uniformity (20 lozenges) disintegration time (6 lozenges), hardness (10 lozenges), anthocyanins assay expressed as cyanidin-3-glucoside using a spectrometric method at pH differential values. The results are expressed as means± standard deviation. The tablets for the two formulas have the same appearance (flat, round, colored in purple - red, non gritty), the dimensional characteristics (height, thickness) are different, average mass complies the pharmacopoeia standards. The lozenges from formula 2 have a higher resistance (215.7 N) and a lower disintegration time (11 min.) according to the official recommended values, due to differences from carbopol polymers differences in properties at the same concentration used in the two formulas. Using the direct compressible products described in this study, the direct compression technique can be easily applied for the manufacture of lozenges, thus ensuring their stability by avoiding heat and humidity factors during the manufacturing process. The resulting lozenges from formula 1 respect the quality specifications provided by the Romanian Pharmacopoeia Xth edition, the European Pharmacopoeia. The lozenges presented a high mechanical resistance (110 N) and a good disintegration time (15 min.)