Cloud-edge collaboration can overcome the shortcomings of high latency of the centralized model of cloud computing and insufficient computing power of edge computing, and better meet the needs of various application scenarios, which has become a research hotspot in recent years. The 6 G network is driven by the deep integration of network and computing, which will further accelerate the collaborative and integrated development of the cloud datacenter, edge servers, end devices, and application. This paper considers the combination of edge computing and cloud computing, and studies the problem of task offloading with the optimization objectives of energy consumption, delay, and multi-node load balancing under an “End-Edge-Cloud” collaborative architecture for 6G network. We regard the problem of task offloading as a multi-objective optimization problem. By improving AR-MOEA, a task offloading algorithm based on the “End-Edge-Cloud” architecture (TO-EEC) is proposed. It is verified through experiments that TO-EEC has a fast convergence speed. Compared with other similar offloading algorithms, TO-EEC has significant optimization effects on energy consumption, delay and multi-node load variance under multiple constraints.

Over the years, numerous evidences have demonstrated that microbes living in the human body are closely related to human life activities and human diseases. However, traditional biological experiments are time-consuming and expensive, so it has become a research topic in bioinformatics to predict potential microbe-disease associations by adopting computational methods. In this study, a novel calculative method called BPNNHMDA is proposed to identify potential microbe-disease associations. In BPNNHMDA, a novel neural network model is first designed to infer potential microbe-disease associations, its input signal is a matrix of known microbe-disease associations, and its output signal is matrix of potential microbe-disease associations probabilities. And moreover, in the novel neural network model, a new activation function is designed to activate the hidden layer and the output layer based on the hyperbolic tangent function, and its initial connection weights are optimized by adopting Gaussian Interaction Profile kernel (GIP) similarity for microbes, which can improve the training speed of BPNNHMDA efficiently. Finally, in order to verify the performance of our prediction model, different frameworks such as the Leave-One-Out Cross Validation (LOOCV) and $k$ -Fold Cross Validation ( $k$ -Fold CV) are implemented on BPNNHMDA respectively. Simulation results illustrate that BPNNHMDA can achieve reliable AUCs of 0.9242, 0.9127 $\pm$ 0.0009 and 0.8955 $\pm$ 0.0018 in LOOCV, 5-Fold CV and 2-Fold CV separately, which are superior to previous state-of-the-art methods. Furthermore, case studies of inflammatory bowel disease (IBD), asthma and obesity demonstrate that BPNNHMDA has excellent prediction ability in practical applications as well.

The ever-increasing requests of users in emergency communication scenarios lead to high data traffic and transmission delay, posing challenges for resource-limited space-air-ground integrated networks (SAGINs). To address this issue, this paper proposes a joint caching optimization and user selection (JCOUS) problem that leverages unmanned aerial vehicle (UAV) caching to maximize the residual energy of the satellite, considering the limited resources of UAVs. To address the complex time-coupling optimization problem with discrete variables, we propose a primal decomposition method to decouple the problem, and design an energy-efficient user selection algorithm with dynamic caching. Furthermore, to reduce computational complexity and cost, we consider a statistical scenario and maximize the statistical residual energy in the JCOUS problem. Simulation results verify that the proposed scheme can achieve a higher residual energy and fast optimization, thus realizing energy saving and quick decision making especially in large-scale computation-intensive SAGINs.

Multi-Access Edge Computing (MEC) is a promising paradigm that providing cloud-like service for handling the high-complexity and latency-sensitive applications on user equipment (UE) via computation offloading. However, the execution reliability is rarely considered in current MEC studies, which is an important factor to guarantee the quality of service (QoS). For that, this paper considers an energy-saving offloading to satisfy the reliability and latency requirements of the application. Specifically, we formulate an optimization problem to minimize the UE’s energy consumption with reliability and latency constraints. To tackle this NP-hard problem, we first divide the entire application into multiple directed-acyclic-graph-(DAG)-based subtasks, where the subtask can be executed on the UE locally or MEC server remotely. Then, we decompose the overall reliability and latency requirements into multiple constraints for each subtask. Finally, we propose a fast heuristic algorithm to find a solution satisfying the constraints. Simulation results demonstrate the proposed algorithm obtains lower energy consumption compared with the local execution and random assignment and costs less runtime compared with the greedy algorithm.

The role of the Internet of Things (IoT) networks and systems in our daily life cannot be underestimated. IoT is among the fastest evolving innovative technologies that are digitizing and interconnecting many domains. Most life-critical and finance-critical systems are now IoT-based. It is, therefore, paramount that the Quality of Service (QoS) of IoTs is guaranteed. Traditionally, IoTs use heuristic, game theory approaches and optimization techniques for QoS guarantee. However, these methods and approaches have challenges whenever the number of users and devices increases or when multicellular situations are considered. Moreover, IoTs receive and generate huge amounts of data that cannot be effectively handled by the traditional methods for QoS assurance, especially in extracting useful features from this data. Deep Learning (DL) approaches have been suggested as a potential candidate in solving and handling the above-mentioned challenges in order to enhance and guarantee QoS in IoT. In this paper, we provide an extensive review of how DL techniques have been applied to enhance QoS in IoT. From the papers reviewed, we note that QoS in IoT-based systems is breached when the security and privacy of the systems are compromised or when the IoT resources are not properly managed. Therefore, this paper aims at finding out how Deep Learning has been applied to enhance QoS in IoT by preventing security and privacy breaches of the IoT-based systems and ensuring the proper and efficient allocation and management of IoT resources. We identify Deep Learning models and technologies described in state-of-the-art research and review papers and identify those that are most used in handling IoT QoS issues. We provide a detailed explanation of QoS in IoT and an overview of commonly used DL-based algorithms in enhancing QoS. Then, we provide a comprehensive discussion of how various DL techniques have been applied for enhancing QoS. We conclude the paper by highlighting the emerging areas of research around Deep Learning and its applicability in IoT QoS enhancement, future trends, and the associated challenges in the application of Deep Learning for QoS in IoT.

Recently, numerous laboratory studies have indicated that many microRNAs (miRNAs) are involved in and associated with human diseases and can serve as potential biomarkers and drug targets. Therefore, developing effective computational models for the prediction of novel associations between diseases and miRNAs could be beneficial for achieving an understanding of disease mechanisms at the miRNA level and the interactions between diseases and miRNAs at the disease level. Thus far, only a few miRNA-disease association pairs are known, and models analyzing miRNA-disease associations based on lncRNA are limited. In this study, a new computational method based on a distance correlation set is developed to predict miRNA-disease associations (DCSMDA) by integrating known lncRNA-disease associations, known miRNA-lncRNA associations, disease semantic similarity, and various lncRNA and disease similarity measures. The novelty of DCSMDA is due to the construction of a miRNA-lncRNA-disease network, which reveals that DCSMDA can be applied to predict potential lncRNA-disease associations without requiring any known miRNA-disease associations. Although the implementation of DCSMDA does not require known disease-miRNA associations, the area under curve is 0.8155 in the leave-one-out cross validation. Furthermore, DCSMDA was implemented in case studies of prostatic neoplasms, lung neoplasms and leukaemia, and of the top 10 predicted associations, 10, 9 and 9 associations, respectively, were separately verified in other independent studies and biological experimental studies. In addition, 10 of the 10 (100%) associations predicted by DCSMDA were supported by recent bioinformatical studies. According to the simulation results, DCSMDA can be a great addition to the biomedical research field.