A dor crônica constitui uma condição de elevada prevalência e complexidade, impactando significativamente a funcionalidade, qualidade de vida e bem-estar biopsicossocial dos indivíduos acometidos. Este estudo objetivou caracterizar o perfil epidemiológico de pacientes com dor crônica atendidos em um ambulatório especializado, analisando os diagnósticos mais frequentes, estratégias terapêuticas empregadas e sua efetividade clínica. Trata-se de um estudo quantitativo, descritivo e retrospectivo, baseado na análise de 426 prontuários de pacientes atendidos nos departamentos de reumatologia e ortopedia. Os resultados evidenciaram predomínio do sexo feminino (85,52%) e idade média de 51 anos. A fibromialgia foi a condição mais prevalente, seguida por osteoartrose e lombalgia. Observou-se alta correlação entre dor crônica e comorbidades psiquiátricas, como depressão e ansiedade, além de hipertensão arterial. O manejo terapêutico foi predominantemente farmacológico, destacando-se o uso de pregabalina, duloxetina e tramadol. No entanto, a adesão a abordagens multidisciplinares foi reduzida, com menos de 40% dos pacientes recebendo suporte fisioterapêutico ou psicológico. A análise dos desfechos terapêuticos sugere que intervenções multimodais, associando terapia medicamentosa e recursos não farmacológicos, promovem melhores resultados clínicos. Conclui-se que a abordagem integrada, aliando estratégias farmacológicas e não farmacológicas, é essencial para otimizar o tratamento da dor crônica, promovendo melhor qualidade de vida para os pacientes.

The Ewing method explores the feedback circuit of the baroreceptor reflex pathway, allowing us to quantify possible changes in vagal-sympathetic tone. The aim of the study was to determine the autonomic functional index of UnirG students as a control protocol. Five clinical trials were carried out on groups of healthy individuals and those with previous/current illnesses. The means and standard deviations of the scores were 0.48 (0.72) and 2.42 (1.74), respectively, with a significant result in the bilateral Mann-Whitney test (p = 0.0002). It can be concluded that the Ewing method showed relative accuracy and specificity with feasibility, given its accessibility, low cost and easy handling. O método de Ewing explora o circuito de feedback da via reflexo barorreceptor permitindo quantificar possíveis alterações do tônus vagal-simpático. O objetivo do estudo foi determinar o índice funcional autonômico de acadêmicos da UnirG com finalidade de protocolo-controle. Foram realizados 5 ensaios clínicos em grupos de indivíduos sadios e de doenças prévias/atuais. As médias e desvios-padrão dos escores foram 0,48 (0,72) e 2,42 (1,74), respectivamente com resultado significativo no teste de Mann-Whitney bilateral (p = 0,0002). Conclui-se que o método de Ewing mostrou relativa acurácia e especificidade com uma exequibilidade, visto a sua acessibilidade, baixo custo e fácil manuseio.

INTRODUÇÃO: A Coronavírus Disease (Covid-19) é uma doença infectocontagiosa causada pelo coronavírus (SAS-CoV-2). Clinicamente, na fase aguda, os pacientes podem ser assintomáticos ou desenvolverem sintomas leves, moderados ou evoluir com sintomas graves ou críticos necessitando ou não de ventilação mecânica invasiva (Soriano et al. 2022). A maioria dos pacientes infectados desenvolve a forma leve da doença. No entanto, a presença de condições médicas subjacentes como a hipertensão arterial sistêmica (HAS), diabetes, o maior índice de massa corporal (IMC), ou doenças respiratórias crônicas - doença pulmonar obstrutiva crônica (DPOC) e asma, contribuem, para o desenvolvimento da forma grave da doença na fase aguda, assim como a permanência dos sintomas pós-Covid-19 ou Covid Longa (Miranda et al, 2022).

Background: The objective of this study was to evaluate the efficacy and safety of CAR-T immunotherapy in inducing remission in patients with Acute Lymphoblastic Leukemia (ALL). Methods: The search strategy was conducted in the BVS, Embase, PubMed, and ScienceDirect databases, where 4138 studies were initially identified. Results: The final analysis resulted in the inclusion of 35 studies, all of which were incorporated into the meta-analysis, covering a cohort of 1313 patients. Statistical analysis was performed using R software (version 4.5.2), revealing a Complete Remission rate of 70.68% and a Minimal Residual Disease negativity rate of 76.68%. Tactical superiority was observed in the second-generation cells and in the dual CD19/CD22 target (82.20% CR). The risk of bias assessment using the ROBINS-I tool indicated high quality for most of the studies. The certainty of evidence according to the GRADE system was classified as moderate. Adverse events such as cytokine release syndrome (46.81%) and neurotoxicity (23.52%) were frequent but reversible. Conclusions: We thus observe that CAR-T therapy is an effective strategic bridge to bone marrow transplantation, with advances in cell persistence being fundamental for sustained cure.

Objective: This study aimed to evaluate the association between T. gondii genotypes (types I, II, III) and cases of spontaneous abortion in humans. Methods: A systematic review and meta-analysis were conducted following PRISMA guidelines. Databases (PubMed, Scopus, Web of Science, EMBASE, and ScienceDirect) were searched for studies published in the last 10 years. Observational studies evaluating T. gondii genotypes in abortion cases were included. Results: Eight cross-sectional studies were included. A pooled positivity proportion for T. gondii of approximately 20% was observed among abortion cases, with substantial heterogeneity (I² > 90%). Genotype distribution varied across studies, with types I and III being the most frequently reported. Conclusions: Available evidence suggests a possible association between T. gondii infection and spontaneous abortion; however, the role of specific genotypes remains uncertain due to limited and heterogeneous data. More multicenter studies are needed to robustly address the issue.

Background/Objectives: Microbial exopolysaccharides (EPS) are complex biopolymers that mimic the native extracellular matrix and have emerged as promising biomaterials for tissue regeneration. Methods: This study aimed to evaluate the therapeutic potential of microbial EPS in the healing of cutaneous wounds through a systematic review and meta-analysis of in vivo experimental studies in rat models. Conducted in accordance with the PRISMA guidelines, a search of the Scopus, Embase, and ScienceDirect databases identified 2496 records. After rigorous screening, 17 rat studies were included in the quantitative synthesis, comprising 181 animals and 398 wounds (199 treated with EPS and 199 controls). Results: Treatment with EPS promoted a mean healing rate of 90.46% (range: 9.1% to 100%) on day 14, reflecting the heterogeneity of the included studies. The meta-analysis revealed an overall mean difference of 21.15% (95% CI: 17.89 to 24.42; p < 0.0001) in favor of EPS compared with the control group. Conclusions: These findings support the potential for translating EPS-based therapies from rodent models to human wounds, although the substantial heterogeneity of the evidence and the absence of clinical data indicate that controlled clinical trials remain essential to validate their application in humans.