Background: Liver cancer is one of the most common malignant tumors in the world. T cell-mediated antitumor immune response is the basis of liver cancer immunotherapy. Objective: To screen and analyze the RNAs associated with activated memory CD4 T cells and CD8 T cells in liver cancer. Methods: ESTIMATE was used to calculate the stromal and immune scores of tumor samples, which were downloaded from The Cancer Genome Atlas (TCGA). The differentially expressed genes (DEGs) in high and low stromal and immune scores were screened, followed by functional enrichment of overlapped DEGs. We then conducted a survival analysis to identify immune-related prognostic indicators and constructed protein-protein interaction (PPI) networks and ceRNA networks. Finally, chemical small-molecule–target interaction pairs associated with liver cancer were screened. Results: A total of 55,955 stromal-related DEGs and 1811 immune-related DEGs were obtained. The 1238 overlapped DEGs were enriched in 1457 biological process terms and 74 KEGG pathways. In addition, a total of 120 activated memory CD4 T cell-related genes and 309 CD8 T cell-related genes were identified. The survival analysis revealed that upregulated expression of T cell-related genes including EOMES, CST7, and CD5L indicated the favorable prognosis of liver cancer. EOMES was regulated by has-miR-23b-3p and has-miR-23b-3p was regulated by lncRNA AC104820.2 in the ceRNA network of activated memory CD4 T cell-related genes. In addition, EOMES was regulated by has-miR-23a-3p and has-miR-23a-3p was regulated by lncRNA AC000476.1 in the ceRNA network of CD8 T cells. Conclusion: T cell-related RNAs EOMES, CST7, CD5L, has-miR-23b-3p, and has-miR-23a-3p may be associated with the prognosis of liver cancer. And the molecular characteristics of these T cell-related genes were plotted.

Oxaliplatin resistance reduces the efficacy of chemotherapy for colorectal cancer (CRC).

Objective: This article systematically reviewed intervention strategies for cancer-related sarcopenia (CRS), providing evidence for researchers to develop targeted treatments. Methods: PubMed, Embase, Web of Science, and the Cochrane Library were searched for studies between 2015 and 2025, followed by literature screening and content analysis. Results: A total of 3,566 articles were initially identified, and 18 randomized controlled trials (published between 2016 and 2025; sample sizes ranging from 15 to 232) were ultimately included. CRS interventions were categorized into four types: nutritional, exercise, pharmacological, and multidisciplinary. Conclusion: A CRS intervention needs an integrated approach that combines nutrition, exercise, pharmacology, and a multidisciplinary team (MDT) to improve patients’ functional outcomes and quality of life. Future research should focus on precision approaches and translational medicine.

Rationale: Esophageal fistula is a rare and serious complication after endoscopic thyroidectomy. Current research focuses more on surgical treatment, while there are few treatment plans for esophageal fistula after endoscopic thyroidectomy. There is currently no standardized intervention for esophageal fistula after thyroid surgery. Patient concerns: The patient wants to cure the esophageal fistula as soon as possible and does not want to have other complications. Diagnoses: The patient was diagnosed with thyroid cancer. Interventions: We summarize the key points of interventions as follows: First, a comprehensive assessment of the patient’s condition was conducted before the surgery, and an individualized surgical approach was formulated. During the operation, preventive intervention measures were carried out. Second, after the surgery, fasting, gastrointestinal decompression, and supportive treatment were provided. Then, an individualized follow-up plan was developed after discharge to prevent long-term complications. At the same time, the negative emotions of the patients were also paid attention to, and timely counseling was given to help them return to society as soon as possible. Outcomes: The patient was hospitalized for 35 days. After the joint efforts of doctors, nurses, and patients, she recovered well and was discharged from the hospital 31 days after surgery. Two-month follow-up after discharge showed that gastrointestinal function recovered well, with no abdominal pain, bloating, diarrhea, nausea, vomiting, and other discomforts, and no long-term complications such as esophageal stenosis. Lessons: The interventions we summarized are effective and feasible for patients with esophageal fistula after endoscopic thyroidectomy.

Objective This paper systematically reviews the influencing factors of affective symptoms and psychological rehabilitation strategies of young breast cancer survivors (aged 50 years and under), so as to meet their psychological rehabilitation needs and provide evidence-based basis for medical staff to formulate precise psychological rehabilitation strategies. Methods. The databases PubMed, Embase, Web of Science, and Cochrane Library were searched for research questions from 2012 to 2022. The literature was screened and evaluated, and the content analysis method was used to conduct a descriptive analysis of the results. Results. A total of 20 studies were included, including 11 cross-sectional studies, 7 randomized controlled trials, and 2 cohort studies. The common affective symptoms of young breast cancer survivors are anxiety, depression and fear, and the influencing factors include personal factors, disease factors, family factors and socioeconomic factors. Conclusions. The influencing factors of affective symptoms in young breast cancer survivors are diverse, and the psychological rehabilitation needs have their unique characteristics, which have not been fully studied. There is an urgent need to conduct high-quality research in this field. According to its influencing factors, psychological rehabilitation strategies need to be developed to maintain their family role and social roles.