The secondary education system is at acrossroads, where the emphasis on knowledge-imparting must be replaced by the ethos of twenty-first-century competencies. The education of entrepreneurship, which has a broad definition not only in terms of business training but also as a transversal competence that promotes ideation, agency, and value creation, has become a critical response to this call. This chapter explores the theoretical underpinnings, strategies for implementation, systemic obstacles, and recorded results of integrating entrepreneurship into secondary school curricula in a global context. Using the EntreComp framework, the Organization for Economic Co-operation and Development (OECD) Learning Compass 2030, and a solid empirical literature base, the chapter outlines the opportunities for reforms in the curriculum, digital integration, and global alignment with Sustainable Development Goals (SDGs) and highlights the barriers that persist in the form of exam-centric cultures, gaps in teacher readiness, and uneven resource distribution. Strategies such as interdisciplinary pedagogy, experiential approaches to learning, school-based businesses, and portfolio-based evaluation are critically examined. Cognitive, affective, and community impact studies have proven that well-established entrepreneurship education has a significant positive influence on the development of critical thinking, self-efficacy, and community problem-solving skills among adolescents. The chapter concludes with future-focused policy integration suggestions, teacher development, and the role of artificial intelligence in fostering entrepreneurial attitudes towards Generation Z and Generation Alpha.