Objectives: The present study evaluates the clinical outcomes of children, adolescents and adults with Ewing sarcoma and identifies the prognostic factors. Methods: Included in the study were 222 pediatric and adult patients diagnosed with Ewing sarcoma (EwS) who were followed up between 1992 and 2019, and whose data were analyzed retrospectively. Results: The median age of 131 male and 91 female patients included in the study was 13 (1–64). The median follow-up duration of the survivors was 79 months (range, 11–182 months). The 3-year EFS rate of the 222 patients was 34 % (Confidence Interval (CI) (0.158–0.242 %) and the OS rate was 54 % (CI, 0.289–0.590 %). For the non-metastatic patients, the 3-year EFS rate was 47 % and the OS was 68 %, while for the metastatic patients the 3-year EFS rate was 13 % and the OS was 30 %. Of the patient sample, 81 (36, 5 %) survived, of whom 72 were continuously free of disease while the disease persisted in nine, and three developed a second neoplasm (2 of whom subsequently died while one survived disease-free). Of the 129 patients who relapsed with metastases and/or local recurrence, eight survived and are disease-free, nine are alive with uncontrolled disease; five were lost to follow-up and 107 died. Conclusion: The findings of the present study suggest metastatic disease at presentation and positive margins after surgery to be of prognostic significance in ES. Disruptions in aggressive local treatments may reduce the chances of cure in EwS.

Cite this article as: Çakmakcı S, Özyörük D, Güreşci S, et al. Orbital alveolar soft part sarcoma misdiagnosed as hemangioma in an infant. Turk Arch Pediatr. 2023;58(1):107-108.

Amaç: Koronavirüs hastalığı 2019 (COVID-19) salgını sırasında sağlık hizmetlerine erişimin kısıtlanması, kanserli hastalar için önemli bir sorundur. Çocukluk çağı kanserleri yüksek oranda tedavi edilebilse de tanı ve tedavi aksamalarının kötü sonuçlara yol açacağı aşikardır. Çalışmamızda yeni tanı konulan ve tedavi gören çocukların kısıtlamalardan etkilenip etkilenmediğini ve kanser tedavisi sırasında COVID-19 tanısı alan hastaların klinik seyir ve sonuçlarını araştırdık.Gereç ve yöntemler: Hasta ebeveynlerine 18 sorudan oluşan bir anket uyguladık. Kanser tedavisi sırasında COVID-19 tanısı alan hastaların dosyaları taranarak veriler kaydedildi.Bulgular: Hastaların 35'i yeni tanı grubunda, 55’i ise tedavisi devam eden gruptaydı. Yeni tanı alan hastaların 13'ü (%38) hastaneye geç başvurduğu için kanser tanısı gecikti. Kemoterapi alan hastaların 9'unda (%16) tedavide gecikme yaşandı. Elli sekiz hasta, kanser tedavisinin farklı aşamalarında COVID-19 enfeksiyonu geçirdi. Hastaların tamamına yakını hafif semptomlarla COVID-19'dan iyileşti.Sonuç: Salgını kontrol altına almak için sıkı önlemler alınması gerekirken, kanser gibi ağır kritik hastalığı olan hastalar dikkatle değerlendirilmeli ve hayati sonuçlar doğurabilecek tedavi gecikmelerinden kaçınılmalıdır. Koronavirüs hastalığı 2019 ile enfekte olan kanserli çocuk hastalarda, hastanın klinik durumu değerlendirilerek kanser tedavisine devam edilmesi düşünülmelidir.

Objective: This study aimed to evaluate clinical characteristics, surgical management approaches, and long-term outcomes of pediatric patients with histopathologically-confirmed pancreatic solid pseudopapillary neoplasm (SPN) at a single tertiary center over 10 years. Methods: A retrospective review was conducted of 16 pediatric patients with pancreatic SPN who were treated at the hospital between 2015 and 2025. Data on demographics, clinical presentation, imaging, surgery, pathology, and follow-up were analyzed. Results: Among the 16 patients, 15 were female and 1 was male, with a median age of 14 years (range: 7-16). Abdominal pain was the most frequent presenting symptom (n=12) and other presentations included jaundice, abdominal swelling, or amenorrhea, while 2 patients reported no symptoms. The pancreatic head was the most common tumor site (n=9), and the median tumor size was 5 cm (range: 1-14 cm). Surgical procedures included enucleation (n=10), distal pancreatectomy (n=3), and the Whipple procedure (n=3). Despite positive surgical margins in 9 patients, only 2 experienced local recurrence. No patients received adjuvant therapy. Postoperative complications occurred in 2 cases. One patient developed papillary thyroid carcinoma during follow-up. The median follow-up duration was 50 months (range: 2-108), and all patients were alive and all but one are disease-free at the last evaluation. Conclusion: Pediatric pancreatic SPN predominantly affects adolescent girls and often presents incidentally. Surgical resection yields excellent long-term outcomes even in the presence of positive margins. Continued follow-up is essential due to potential recurrence and rare secondary malignancies.