Computer-Aided Design and Applications is an international journal on the applications of CAD and CAM. It publishes papers in the general domain of CAD plus in emerging fields like bio-CAD, nano-CAD, soft-CAD, garment-CAD, PLM, PDM, CAD data mining, CAD and the internet, CAD education, genetic algorithms and CAD engines. The journal is aimed at all developers and users of CAD technology to ptovide CAD solutions for various stages of design and manufacturing. The journal publishes all about Computer-Aided Design and Computer-Aided technologies.

This case study examines a long-term study on patient experience to identify value generated through collaborative medical design research, in developing a scalp cooling device to prevent chemotherapy-induced alopecia (CIA)/hair-loss. Developing a new medical device is long and complex, requiring a cross-platform multi-disciplinary team. User feedback is essential to ensure continuous development to improve efficacy. Qualitative and quantitative data was gathered from chemotherapy patients using scalp cooling in 9 different countries. Analysis of patient experience captures the impact design research has had for scalp cooling patients globally and guides continuous development, placing the patient at the centre of the design method, driven primarily by the aim of maximizing treatment efficacy for all patients and promoting positive patient experiences. Overall, patient experience of scalp cooling using this device is highly positive and impacts significantly on five key areas of wellbeing. The outcomes will help develop an improved cap for global use.

Computer-Aided Design and Applications is an international journal on the applications of CAD and CAM. It publishes papers in the general domain of CAD plus in emerging fields like bio-CAD, nano-CAD, soft-CAD, garment-CAD, PLM, PDM, CAD data mining, CAD and the internet, CAD education, genetic algorithms and CAD engines. The journal is aimed at all developers and users of CAD technology to ptovide CAD solutions for various stages of design and manufacturing. The journal publishes all about Computer-Aided Design and Computer-Aided technologies.

Flexible heat exchangers with intricate three-dimensional (3D) geometries exhibit superior mechanical and thermal performance compared with traditional two-dimensional (2D) designs. Their ability to offer greater design freedom and unique functionalities makes them particularly attractive for wearable medical devices. This study investigates flexible heat exchanger technologies in three main directions: (i) miniaturisation, (ii) integration of physical and mathematical models, and (iii) enhanced adaptability through heterogeneous design integration. Through a combination of literature review, mathematical modelling, and experimental analysis, the thermal efficiency of several configurations is compared, including basic thermoplastic polyurethane (TPU) tubes and 3D bio-inspired TPU tubes with aluminium-finned structures. The findings establish a foundation for the development of next-generation flexible wearable medical cooling devices with improved thermal management capabilities and practical applicability in industrial design. Furthermore, the outcomes of this research will directly support the development of improved wearable cooling devices within a UK-based medical device SME, Paxman Scalp Coolers, facilitating the translation of advanced heat exchanger designs into clinically relevant and commercially viable solutions.

Purpose: Chemotherapy-induced peripheral neuropathy (CIPN) is a common dose-limiting toxicity of taxane-based chemotherapy with no established preventive strategy. We evaluated the safety, tolerability, and efficacy of a novel limb cryocompression device in reducing CIPN. Methods: In this prospective single-arm phase I/II study conducted at three sites in Singapore, patients with cancer scheduled for taxane-based chemotherapy received limb cryocompression (11°C; cyclic compression 5-15 mm Hg), starting 30 minutes before, during, and 30 minutes after taxane infusion. Primary end points included safety, tolerability, and clinically significant CIPN. CIPN was assessed by physician-graded Common Terminology Criteria for Adverse Events (CTCAE) and the patient-reported European Organisation for Research and Treatment of Cancer Quality of Life Questionnaire-CIPN 20-item scale (EORTC QLQ-CIPN20). A ≥3-point increase in the EORTC QLQ-CIPN20 sensory subscale defined clinically significant patient-reported CIPN. Taxane dose modifications attributable to CIPN were recorded. Results: A total of 150 patients were enrolled (median age 52 years; 96.6% female; 89.0% breast cancer). Taxane regimens included paclitaxel (71.2%), docetaxel (28.1%), and nab-paclitaxel (0.68%); 44.5% received concurrent scalp cooling. A total of 146 patients were evaluable as four patients withdrew before commencing cryocompression. Tolerability was 84.2%; 123 patients completed all cryocompression cycles without premature termination. Fifteen patients (10.3%) withdrew because of cold intolerance. At treatment completion, 22.8% had CTCAE G1 CIPN and 1.6% had G2 CIPN; none developed G3/4 CIPN. Clinically significant patient-reported sensory CIPN occurred in 13.9% at 12 weeks and 13.1% at 24 weeks, and 5.7% required taxane dose modification because of CIPN. Conclusion: Limb cryocompression is safe, well-tolerated, and associated with low rates of clinically significant CIPN in patients receiving taxane-based chemotherapy. A multicenter randomized controlled trial is ongoing to validate these findings (SWOG S2205 ICE COMPRESS; ClinicalTrials.gov identifier: NCT05642611 ).