A three dimensional (3D) computational fluid dynamics (CFD) simulation and a neural network model are presented to estimate the behaviors of the Colburn factor (j) and the Fanning friction factor (f) for wavy fin - and - flat tube (WFFT) heat exchangers. Effects of the five geometrical factors of fin pitch, fin height, fin length, fin thickness, and wavy amplitude are investigated over a wide range of Reynolds number (600