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Dr. Nazely Diban
Department Chemical and Biomolecular Engineering, University of Cantabria, Spain

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polymeric membranes
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Perfusion bioreactors
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Photocatalytic membranes
Graphene-based nanomaterials

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Journal article
Published: 24 February 2021 in Polymers
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The effect of the temperature, as a process variable in the fabrication of polymeric membranes by the non-solvent induced phase separation (NIPS) technique, has been scarcely studied. In the present work, we studied the influence of temperature, working at 293, 313 and 333 K, on the experimental binodal curves of four ternary systems composed of PVDF and PES as the polymers, DMAc and NMP as the solvents and water as the non-solvent. The increase of the temperature caused an increase on the solubility gap of the ternary system, as expected. The shift of the binodal curve with the temperature was more evident in PVDF systems than in PES systems indicating the influence of the rubbery or glassy state of the polymer on the thermodynamics of phase separation. As a novelty, the present work has introduced the temperature influence on the Flory–Huggins model to fit the experimental cloud points. Binary interaction parameters were calculated as a function of the temperature: (i) non-solvent/solvent (g12 ) expressions with UNIFAC-Dortmund methodology and (ii) non-solvent/polymer (χ13 ) and solvent/polymer (χ23 ) using Hansen solubility parameters. Additionally, the effect of the ternary interaction term was not negligible in the model. Estimated ternary interaction parameters (χ123 ) presented a linear relation with temperature and negative values, indicating that the solubility of the polymers in mixtures of solvent/non-solvent was higher than expected for single binary interaction. Finally, PES ternary systems exhibited higher influence of the ternary interaction parameter than PVDF systems.

ACS Style

Marta Romay; Nazely Diban; Ane Urtiaga. Thermodynamic Modeling and Validation of the Temperature Influence in Ternary Phase Polymer Systems. Polymers 2021, 13, 678 .

AMA Style

Marta Romay, Nazely Diban, Ane Urtiaga. Thermodynamic Modeling and Validation of the Temperature Influence in Ternary Phase Polymer Systems. Polymers. 2021; 13 (5):678.

Chicago/Turabian Style

Marta Romay; Nazely Diban; Ane Urtiaga. 2021. "Thermodynamic Modeling and Validation of the Temperature Influence in Ternary Phase Polymer Systems." Polymers 13, no. 5: 678.

Journal article
Published: 22 July 2020 in Membranes
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There is a huge interest in developing novel hollow fiber (HF) membranes able to modulate neural differentiation to produce in vitro blood–brain barrier (BBB) models for biomedical and pharmaceutical research, due to the low cell-inductive properties of the polymer HFs used in current BBB models. In this work, poly(ε-caprolactone) (PCL) and composite PCL/graphene (PCL/G) HF membranes were prepared by phase inversion and were characterized in terms of mechanical, electrical, morphological, chemical, and mass transport properties. The presence of graphene in PCL/G membranes enlarged the pore size and the water flux and presented significantly higher electrical conductivity than PCL HFs. A biocompatibility assay showed that PCL/G HFs significantly increased C6 cells adhesion and differentiation towards astrocytes, which may be attributed to their higher electrical conductivity in comparison to PCL HFs. On the other hand, PCL/G membranes produced a cytotoxic effect on the endothelial cell line HUVEC presumably related with a higher production of intracellular reactive oxygen species induced by the nanomaterial in this particular cell line. These results prove the potential of PCL HF membranes to grow endothelial cells and PCL/G HF membranes to differentiate astrocytes, the two characteristic cell types that could develop in vitro BBB models in future 3D co-culture systems.

ACS Style

Marián Mantecón-Oria; Nazely Diban; Maria T. Berciano; Maria J. Rivero; Oana David; Miguel Lafarga; Olga Tapia; Ane Urtiaga. Hollow Fiber Membranes of PCL and PCL/Graphene as Scaffolds with Potential to Develop in vitro Blood–Brain Barrier Models. Membranes 2020, 10, 161 .

AMA Style

Marián Mantecón-Oria, Nazely Diban, Maria T. Berciano, Maria J. Rivero, Oana David, Miguel Lafarga, Olga Tapia, Ane Urtiaga. Hollow Fiber Membranes of PCL and PCL/Graphene as Scaffolds with Potential to Develop in vitro Blood–Brain Barrier Models. Membranes. 2020; 10 (8):161.

Chicago/Turabian Style

Marián Mantecón-Oria; Nazely Diban; Maria T. Berciano; Maria J. Rivero; Oana David; Miguel Lafarga; Olga Tapia; Ane Urtiaga. 2020. "Hollow Fiber Membranes of PCL and PCL/Graphene as Scaffolds with Potential to Develop in vitro Blood–Brain Barrier Models." Membranes 10, no. 8: 161.

Preprint
Published: 17 July 2020
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There is a huge interest in developing novel hollow fiber (HF) membranes able to modulate neural differentiation to produce in vitro blood-brain barrier (BBB) models for biomedical and pharmaceutical research, due to the low cell-inductive properties of the polymer HFs used in current BBB models. In this work, poly(ε-caprolactone) (PCL) and composite PCL/graphene (PCL/G) HF membranes were prepared by phase inversion and were characterized in terms of mechanical, electrical, morphological, chemical, and mass transport properties. The presence of graphene in PCL/G membranes enlarged the pore size and the water flux and presented significantly higher electrical conductivity than PCL HFs. Biocompatibility assay showed that PCL/G HFs significantly increased C6 cells adhesion and differentiation towards astrocytes, may be attributed to their higher electrical conductivity in comparison to PCL HFs. On the other hand, PCL/G membranes produced a cytotoxic effect on the endothelial cell line HUVEC presumably related with a higher production of intracellular reactive oxygen species induced by the nanomaterial in this particular cell line. These results prove the potential of PCL HF membranes to grow endothelial cells and PCL/G HF membranes to differentiate astrocytes, the two characteristic cell types that could develop in vitro BBB models in future 3D co-culture systems.

ACS Style

Marián Mantecón-Oria; Nazely Diban; Maria T. Berciano; Maria J. Rivero; Oana David; Miguel Lafarga; Olga Tapia; Ane Urtiaga. Novel Hollow Fiber Membranes of PCL and PCL/Graphene as Scaffolds with Potential to Develop in vitro Blood-brain Barrier Models. 2020, 1 .

AMA Style

Marián Mantecón-Oria, Nazely Diban, Maria T. Berciano, Maria J. Rivero, Oana David, Miguel Lafarga, Olga Tapia, Ane Urtiaga. Novel Hollow Fiber Membranes of PCL and PCL/Graphene as Scaffolds with Potential to Develop in vitro Blood-brain Barrier Models. . 2020; ():1.

Chicago/Turabian Style

Marián Mantecón-Oria; Nazely Diban; Maria T. Berciano; Maria J. Rivero; Oana David; Miguel Lafarga; Olga Tapia; Ane Urtiaga. 2020. "Novel Hollow Fiber Membranes of PCL and PCL/Graphene as Scaffolds with Potential to Develop in vitro Blood-brain Barrier Models." , no. : 1.

Review
Published: 19 May 2020 in Catalysts
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Photocatalytic membrane reactors (PMR), with immobilized photocatalysts, play an important role in process intensification strategies; this approach offers a simple solution to the typical catalyst recovery problem of photocatalytic processes and, by simultaneous filtration and photocatalysis of the aqueous streams, facilitates clean water production in a single unit. The synthesis of polymer photocatalytic membranes has been widely explored, while studies focused on ceramic photocatalytic membranes represent a minority. However, previous reports have identified that the successful synthesis of polymeric photocatalytic membranes still faces certain challenges that demand further research, e.g., (i) reduced photocatalytic activity, (ii) photocatalyst stability, and (iii) membrane aging, to achieve technological competitiveness with respect to suspended photocatalytic systems. The novelty of this review is to go a step further to preceding literature by first, critically analyzing the factors behind these major limitations and second, establishing useful guidelines. This information will help researchers in the field in the selection of the membrane materials and synthesis methodology for a better performance of polymeric photocatalytic membranes with targeted functionality; special attention is focused on factors affecting membrane aging and photocatalyst stability.

ACS Style

Marta Romay; Nazely Diban; Maria J. Rivero; Ane Urtiaga; Inmaculada Ortiz. Critical Issues and Guidelines to Improve the Performance of Photocatalytic Polymeric Membranes. Catalysts 2020, 10, 570 .

AMA Style

Marta Romay, Nazely Diban, Maria J. Rivero, Ane Urtiaga, Inmaculada Ortiz. Critical Issues and Guidelines to Improve the Performance of Photocatalytic Polymeric Membranes. Catalysts. 2020; 10 (5):570.

Chicago/Turabian Style

Marta Romay; Nazely Diban; Maria J. Rivero; Ane Urtiaga; Inmaculada Ortiz. 2020. "Critical Issues and Guidelines to Improve the Performance of Photocatalytic Polymeric Membranes." Catalysts 10, no. 5: 570.

Journal article
Published: 01 January 2019 in Separation and Purification Technology
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This work aims to study the effect of the distinctive chemical and structural surface features of boron doped diamond (BDD) anodes on their electrochemical performance for perfluorooctanoic acid (PFOA) degradation. Commercial BDD anodes were compared: i) a microcrystalline (MCD) coating on silicon; and ii) an ultrananocrystalline (UNCD) coating on niobium. MCD gave rise to the complete PFOA (0.24 mmol.L-1) degradation in 4h, at any applied current density in the range 1-5 mA.cm-2. On the contrary, only 21% PFOA removal was achieved when using UNCD at 5 mA.cm-2 under comparable experimental conditions. Similarly, the total organic carbon (TOC) was reduced by 89% using MCD, whereas only 13% TOC decrease was obtained by UNCD. In order to explain the dissimilar electrochemical activities, the morphological and chemical characterization of the electrode materials was developed by means of FESEM microscopy, XPS and Raman spectroscopy. The UNCD anode surface showed characteristic ultrananocrystalline grain size (2-25 nm), higher boron doping and greater content of H-terminated carbon, whereas the MCD anode was less conductive but contained higher sp3 carbon on the anode surface. Overall, the MCD electrode features allowed more efficient PFOA electrolysis than the UNCD anode. As a result of their distinctive performance, the energy needed for the maximum PFOA degradation (after 4h) using MCD anode was only 1.4 kWh.m-3, while the estimated energy consumption for the UNCD anode would be 37-fold higher. It is concluded that the use of the MCD anode involves considerable energy costs savings.

ACS Style

Beatriz Gomez-Ruiz; Nazely Diban; Ane Urtiaga. Comparison of microcrystalline and ultrananocrystalline boron doped diamond anodes: Influence on perfluorooctanoic acid electrolysis. Separation and Purification Technology 2019, 208, 169 -177.

AMA Style

Beatriz Gomez-Ruiz, Nazely Diban, Ane Urtiaga. Comparison of microcrystalline and ultrananocrystalline boron doped diamond anodes: Influence on perfluorooctanoic acid electrolysis. Separation and Purification Technology. 2019; 208 ():169-177.

Chicago/Turabian Style

Beatriz Gomez-Ruiz; Nazely Diban; Ane Urtiaga. 2019. "Comparison of microcrystalline and ultrananocrystalline boron doped diamond anodes: Influence on perfluorooctanoic acid electrolysis." Separation and Purification Technology 208, no. : 169-177.

Full paper
Published: 05 September 2018 in Macromolecular Bioscience
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The effect of doping graphene oxide (GO) and reduced graphene oxide (rGO) into poly(ε‐caprolactone) (PCL) membranes prepared by solvent induced phase separation is evaluated in terms of nanomaterial distribution and compatibility with neural stem cell growth and functional differentiation. Raman spectra analyses demonstrate the homogeneous distribution of GO on the membrane surface while rGO concentration increases gradually toward the center of the membrane thickness. This behavior is associated with electrostatic repulsion that PCL exerted toward the polar GO and its affinity for the non‐polar rGO. In vitro cell studies using human induced pluripotent cell derived neural progenitor cells (NPCs) show that rGO increases marker expression of NPCs differentiation with respect to GO (significantly to tissue culture plate (TCP)). Moreover, the distinctive nanomaterials distribution defines the cell‐to‐nanomaterial interaction on the PCL membranes: GO nanomaterials on the membrane surface favor higher number of active matured neurons, while PCL/rGO membranes present cells with significantly higher magnitude of neural activity compared to TCP and PCL/GO despite there being no direct contact of rGO with the cells on the membrane surface. Overall, this work evidences the important role of rGO electrical properties on the stimulation of neural cell electro‐activity on PCL membrane scaffolds.

ACS Style

Sandra Sánchez‐González; Nazely Diban; Fabio Bianchi; Hua Ye; Ane Urtiaga. Evidences of the Effect of GO and rGO in PCL Membranes on the Differentiation and Maturation of Human Neural Progenitor Cells. Macromolecular Bioscience 2018, 18, e1800195 .

AMA Style

Sandra Sánchez‐González, Nazely Diban, Fabio Bianchi, Hua Ye, Ane Urtiaga. Evidences of the Effect of GO and rGO in PCL Membranes on the Differentiation and Maturation of Human Neural Progenitor Cells. Macromolecular Bioscience. 2018; 18 (11):e1800195.

Chicago/Turabian Style

Sandra Sánchez‐González; Nazely Diban; Fabio Bianchi; Hua Ye; Ane Urtiaga. 2018. "Evidences of the Effect of GO and rGO in PCL Membranes on the Differentiation and Maturation of Human Neural Progenitor Cells." Macromolecular Bioscience 18, no. 11: e1800195.

Journal article
Published: 01 August 2018 in Membranes
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High porosity and mass transport properties of microfiltration polymeric membranes benefit nutrients supply to cells when used as scaffolds in interstitial perfusion bioreactors for tissue engineering. High nutrients transport is assumed when pore size and porosity of the membrane are in the micrometric range. The present work demonstrates that the study of membrane fouling by proteins present in the culture medium, though not done usually, should be included in the routine testing of new polymer membranes for this intended application. Two poly(ε-caprolactone) microfiltration membranes presenting similar average pore size (approximately 0.7 µm) and porosity (>80%) but different external surface porosity and pore size have been selected as case studies. The present work demonstrates that a membrane with lower surface pore abundance and smaller external pore size (approximately 0.67 µm), combined with adequate hydrodynamics and tangential flow filtration mode is usually more convenient to guarantee high flux of nutrients. On the contrary, having large external pore size (approximately 1.70 µm) and surface porosity would incur important internal protein fouling that could not be prevented with the operation mode and hydrodynamics of the perfusion system. Additionally, the use of glycerol in the drying protocols of the membranes might cause plasticization and a consequent reduction of mass transport properties due to membrane compaction by the pressure exerted to force perfusion. Therefore, preferentially, drying protocols that omit the use of plasticizing agents are recommended.

ACS Style

Nazely Diban; Beatriz Gómez-Ruiz; María Lázaro-Díez; Jose Ramos-Vivas; Inmaculada Ortiz; Ane Urtiaga. Factors Affecting Mass Transport Properties of Poly(ε-caprolactone) Membranes for Tissue Engineering Bioreactors. Membranes 2018, 8, 51 .

AMA Style

Nazely Diban, Beatriz Gómez-Ruiz, María Lázaro-Díez, Jose Ramos-Vivas, Inmaculada Ortiz, Ane Urtiaga. Factors Affecting Mass Transport Properties of Poly(ε-caprolactone) Membranes for Tissue Engineering Bioreactors. Membranes. 2018; 8 (3):51.

Chicago/Turabian Style

Nazely Diban; Beatriz Gómez-Ruiz; María Lázaro-Díez; Jose Ramos-Vivas; Inmaculada Ortiz; Ane Urtiaga. 2018. "Factors Affecting Mass Transport Properties of Poly(ε-caprolactone) Membranes for Tissue Engineering Bioreactors." Membranes 8, no. 3: 51.

Article
Published: 05 March 2018 in Membranes
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The present work studies the functional behavior of novel poly(ε-caprolactone) (PCL) membranes functionalized with reduced graphene oxide (rGO) nanoplatelets under simulated in vitro culture conditions (phosphate buffer solution (PBS) at 37 °C) during 1 year, in order to elucidate their applicability as scaffolds for in vitro neural regeneration. The morphological, chemical, and DSC results demonstrated that high internal porosity of the membranes facilitated water permeation and procured an accelerated hydrolytic degradation throughout the bulk pathway. Therefore, similar molecular weight reduction, from 80 kDa to 33 kDa for the control PCL, and to 27 kDa for PCL/rGO membranes, at the end of the study, was observed. After 1 year of hydrolytic degradation, though monomers coming from the hydrolytic cleavage of PCL diffused towards the PBS medium, the pH was barely affected, and the rGO nanoplatelets mainly remained in the membranes which envisaged low cytotoxic effect. On the other hand, the presence of rGO nanomaterials accelerated the loss of mechanical stability of the membranes. However, it is envisioned that the gradual degradation of the PCL/rGO membranes could facilitate cells infiltration, interconnectivity, and tissue formation.

ACS Style

Sandra Sánchez-González; Nazely Diban; Ane Urtiaga. Hydrolytic Degradation and Mechanical Stability of Poly(ε-Caprolactone)/Reduced Graphene Oxide Membranes as Scaffolds for In Vitro Neural Tissue Regeneration. Membranes 2018, 8, 12 .

AMA Style

Sandra Sánchez-González, Nazely Diban, Ane Urtiaga. Hydrolytic Degradation and Mechanical Stability of Poly(ε-Caprolactone)/Reduced Graphene Oxide Membranes as Scaffolds for In Vitro Neural Tissue Regeneration. Membranes. 2018; 8 (1):12.

Chicago/Turabian Style

Sandra Sánchez-González; Nazely Diban; Ane Urtiaga. 2018. "Hydrolytic Degradation and Mechanical Stability of Poly(ε-Caprolactone)/Reduced Graphene Oxide Membranes as Scaffolds for In Vitro Neural Tissue Regeneration." Membranes 8, no. 1: 12.

Journal article
Published: 01 February 2018 in Journal of Hazardous Materials
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The inherent resistance of perfluoroalkyl substances (PFASs) to biological degradation makes necessary to develop advanced technologies for the abatement of this group of hazardous substances. The present work investigated the photocatalytic decomposition of perfluorooctanoic acid (PFOA) using a composite catalyst based on TiO and reduced graphene oxide (95% TiO/5% rGO) that was synthesized using a facile hydrothermal method. The efficient photoactivity of the TiO-rGO (0.1gL) composite was confirmed for PFOA (0.24mmolL) degradation that reached 93±7% after 12h of UV-vis irradiation using a medium pressure mercury lamp, a great improvement compared to the TiO photocatalysis (24±11% PFOA removal) and direct photolysis (58±9%). These findings indicate that rGO provided the suited properties of TiO-rGO, possibly as a result of acting as electron acceptor and avoiding the high recombination electron/hole pairs. The release of fluoride and the formation of shorter-chain perfluorocarboxilyc acids, that were progressively eliminated in a good match with the analysed reduction of total organic carbon, is consistent with a step-by-step PFOA decomposition via photogenerated hydroxyl radicals. Finally, the apparent first order rate constants of the TiO-rGO UV-vis PFOA decompositions, and the intermediate perfluorcarboxylic acids were found to increase as the length of the carbon chain was shorter.

ACS Style

Beatriz Gomez-Ruiz; Paula Ribao; Nazely Diban; Maria Rivero; Inmaculada Ortiz; Ane Urtiaga. Photocatalytic degradation and mineralization of perfluorooctanoic acid (PFOA) using a composite TiO2 −rGO catalyst. Journal of Hazardous Materials 2018, 344, 950 -957.

AMA Style

Beatriz Gomez-Ruiz, Paula Ribao, Nazely Diban, Maria Rivero, Inmaculada Ortiz, Ane Urtiaga. Photocatalytic degradation and mineralization of perfluorooctanoic acid (PFOA) using a composite TiO2 −rGO catalyst. Journal of Hazardous Materials. 2018; 344 ():950-957.

Chicago/Turabian Style

Beatriz Gomez-Ruiz; Paula Ribao; Nazely Diban; Maria Rivero; Inmaculada Ortiz; Ane Urtiaga. 2018. "Photocatalytic degradation and mineralization of perfluorooctanoic acid (PFOA) using a composite TiO2 −rGO catalyst." Journal of Hazardous Materials 344, no. : 950-957.

Journal article
Published: 05 January 2018 in Environmental Science and Pollution Research
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Electrochemical oxidation (ELOX) with boron-doped diamond (BDD) anodes was successfully applied to degrade a model aqueous solution of a mixture of commercial naphthenic acids (NAs). The model mixture was prepared resembling the NA and salt composition of oil sands process-affected water (OSPW) as described in the literature. The initial concentration of NAs between 70 and 120 mg/L did not influence the electrooxidation kinetics. However, increasing the applied current density from 20 to 100 A/m2 and the initial chloride concentration from 15 to 70 and 150 mg/L accelerated the rate of NA degradation. At higher chloride concentration, the formation of indirect oxidative species could contribute to the faster oxidation of NAs. Complete chemical oxygen demand removal at an initial NA concentration of 120 mg/L, 70 mg/L of chloride and applied 50 A/m2 of current density was achieved, and 85% mineralization, defined as the decrease of the total organic carbon (TOC) content, was attained. Moreover, after 6 h of treatment and independently on the experimental conditions, the formation of more toxic species, i.e. perchlorate and organochlorinated compounds, was not detected. Finally, the use of ELOX with BDD anodes produced a 7 to 11-fold reduction of toxicity (IC50 towards Vibrio fischeri) after 2 h of treatment.

ACS Style

Nazely Diban; Ane Urtiaga. Electrochemical mineralization and detoxification of naphthenic acids on boron-doped diamond anodes. Environmental Science and Pollution Research 2018, 25, 34922 -34929.

AMA Style

Nazely Diban, Ane Urtiaga. Electrochemical mineralization and detoxification of naphthenic acids on boron-doped diamond anodes. Environmental Science and Pollution Research. 2018; 25 (35):34922-34929.

Chicago/Turabian Style

Nazely Diban; Ane Urtiaga. 2018. "Electrochemical mineralization and detoxification of naphthenic acids on boron-doped diamond anodes." Environmental Science and Pollution Research 25, no. 35: 34922-34929.

Journal article
Published: 01 January 2018 in DESALINATION AND WATER TREATMENT
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ACS Style

F.J. Alguacil; N. Diban; A. Urtiaga. Zinc and iron removal from chromium(III) passivation baths by solvent extraction with Cyanex 272. DESALINATION AND WATER TREATMENT 2018, 133, 252 -256.

AMA Style

F.J. Alguacil, N. Diban, A. Urtiaga. Zinc and iron removal from chromium(III) passivation baths by solvent extraction with Cyanex 272. DESALINATION AND WATER TREATMENT. 2018; 133 ():252-256.

Chicago/Turabian Style

F.J. Alguacil; N. Diban; A. Urtiaga. 2018. "Zinc and iron removal from chromium(III) passivation baths by solvent extraction with Cyanex 272." DESALINATION AND WATER TREATMENT 133, no. : 252-256.

Journal article
Published: 01 October 2017 in Journal of Membrane Science
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Promising polymer membranes of blended biocompatible poly(ε-caprolactone) and graphene oxide (PCL/GO) and PCL and partially reduced graphene oxide (PCL/rGO) with outstanding water and nutrient transport properties for cell culture bioreactors were prepared using phase inversion at mild temperatures. Some of the prepared PCL/GO membranes were subjected to a 'chemical-free' GO post-reductive process using UV (PCL/GO/UV) irradiation. The PCL/rGO membranes exhibited 2.5 times higher flux than previously reported biocompatible polymer membranes for cell culture bioreactors, which was attributed to the highly interconnected porosity. On the other hand, the formation of PCL-graphene oxide composites in the PCL/GO and PCL/GO/UV membranes was not conclusive according to spectroscopic analyses, thermal analyses and mechanical characterization, probably due to the low graphene oxide loading in the membranes (0.1%w/w). The presence of graphene oxide-based nanomaterials in the polymer matrix slightly reduced the mechanical properties of the PCL-graphene oxide membranes by limiting the polymer chain mobility in comparison to that of the plain PCL membranes. However, their mechanical stability was sufficient for the applications pursued. Finally, the biocompatibility assay indicated that the incorporation of GO and rGO into the PCL matrix enhanced the uniform distribution and morphology of the glioblastoma cells on the surface of the PCL-graphene oxide membranes.Financial support of the Cantabria Explora call through project JP03.640.69 is gratefully acknowledged

ACS Style

Nazely Diban; Sandra Sánchez-González; Maria Lázaro-Díez; Jose Ramos-Vivas; Ane Urtiaga. Facile fabrication of poly(ε-caprolactone)/graphene oxide membranes for bioreactors in tissue engineering. Journal of Membrane Science 2017, 540, 219 -228.

AMA Style

Nazely Diban, Sandra Sánchez-González, Maria Lázaro-Díez, Jose Ramos-Vivas, Ane Urtiaga. Facile fabrication of poly(ε-caprolactone)/graphene oxide membranes for bioreactors in tissue engineering. Journal of Membrane Science. 2017; 540 ():219-228.

Chicago/Turabian Style

Nazely Diban; Sandra Sánchez-González; Maria Lázaro-Díez; Jose Ramos-Vivas; Ane Urtiaga. 2017. "Facile fabrication of poly(ε-caprolactone)/graphene oxide membranes for bioreactors in tissue engineering." Journal of Membrane Science 540, no. : 219-228.

Journal article
Published: 01 August 2017 in Chemical Engineering Journal
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This paper reports the electrochemical treatment of poly- and perfluoroalkyl substances (PFASs) in the effluent from an industrial wastewater treatment plant (WWTP). While most of the previous research focused on the electrochemical degradation of perfluorooctanoic acid and perfluorooctane sulfonate in model solutions, this work studies the simultaneous removal of 8 PFASs at environmentally relevant concentrations in real industrial emissions, which also contained organic matter and inorganic anions. The overall PFASs content in the WWTP effluent was 1652 µg/L, which emphasized the need to develop innovative technologies for the management of PFASs emissions. 6:2 fluorotelomer sulfonamide alkylbetaine (6:2 FTAB) and 6:2 fluorotelomer sulfonate (6:2 FTSA) were the major contributors (92% w/w) to the overall PFASs content, that also contained significant amounts of short-chain perfluorocarboxylic acids (PFCAs). Using a boron doped diamond (BDD) anode of 0.0070 m2, the effluent (2 L) was treated by applying a current density of 50 mA/cm2 for 10 h, that resulted in 99.7% PFASs removal. The operation at lower current densities (5 and 10 mA/cm2) evidenced the initial degradation of 6:2 fluorotelomers into perfluoroheptanoic and perfluorohexanoic acids, that were later degraded into shorter chain PFCAs. The high TOC removal, >90%, and the fluoride release revealed that PFASs mineralization was effective. These results highlight the potential of the electrochemical technology for the treatment of PFASs contained in industrial wastewaters, which nowadays stands as the main source of this group of persistent pollutants into the environment.Financial support of project CTM2013-44081-R (MINECO, SPAIN-FEDER 2014–2020) is acknowledged. B. Gomez also thanks the FPI grant (BES-2014-071045)

ACS Style

Beatriz Gomez-Ruiz; Sonia Gómez-Lavín; Nazely Diban; Virginie Boiteux; Adeline Colin; Xavier Dauchy; Ane Urtiaga. Efficient electrochemical degradation of poly- and perfluoroalkyl substances (PFASs) from the effluents of an industrial wastewater treatment plant. Chemical Engineering Journal 2017, 322, 196 -204.

AMA Style

Beatriz Gomez-Ruiz, Sonia Gómez-Lavín, Nazely Diban, Virginie Boiteux, Adeline Colin, Xavier Dauchy, Ane Urtiaga. Efficient electrochemical degradation of poly- and perfluoroalkyl substances (PFASs) from the effluents of an industrial wastewater treatment plant. Chemical Engineering Journal. 2017; 322 ():196-204.

Chicago/Turabian Style

Beatriz Gomez-Ruiz; Sonia Gómez-Lavín; Nazely Diban; Virginie Boiteux; Adeline Colin; Xavier Dauchy; Ane Urtiaga. 2017. "Efficient electrochemical degradation of poly- and perfluoroalkyl substances (PFASs) from the effluents of an industrial wastewater treatment plant." Chemical Engineering Journal 322, no. : 196-204.

Journal article
Published: 01 August 2017 in Journal of Electroanalytical Chemistry
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The aim of this study was to determine the viability of electrochemical oxidation to degrade and mineralize poly- and perfluoroalkyl substances (PFASs) in wastewaters from an industrial facility dedicated to the production of side-chain-fluorinated polymers and fluorotelomer-based products for fire-fighting foams. 6:2 fluorotelomer sulfonamide alkylbetaine (6:2 FTAB, 1111 μg/L), 6:2 fluorotelomer sulfonic acid (6:2 FTSA, 242.5 μg/L) and 6:2 fluorotelomer sulfonamide propyl N,N dimethylamine (M4, 34.4 μg/L) were the most abundant PFASs in the industrial wastewater, that also contained perfluorocarboxylic acids (ΣPFCAs, 12.2 μg/L), high TOC and chloride as main anion. 2 L samples were treated in bench scale experiments performed at a current density of 50 mA/cm2, in a commercial cell equipped with a boron doped diamond (BDD) anode (70 cm2). 97.1% of the initial PFASs content was removed after 8 h of electrochemical treatment. Furthermore, the TOC removal (82.5%) and the fluoride release confirmed the PFASs mineralization. Based on the evolution of the different PFASs, electrochemical degradation pathways were proposed. Fluorotelomers sulfonamides 6:2 FTAB and M4 would be degraded into 6:2 FTSA, which conversely would give rise to PFHpA and preferentially PFHxA. The latter PFCAs were transformed into shorter-chain PFCAs, and eventually into CO2 and fluoride. The reported results support the technical viability of BDD electrooxidation for the treatment of PFASs in industrial wastewater.This work was supported by the Spanish Ministry of Economy and Competitiveness (CTM2013-44081-R and CTM2016-75509-R). B. Gomez also thanks the FPI postgraduate research grant (BES-2014-071045)

ACS Style

Beatriz Gomez-Ruiz; Sonia Gómez-Lavín; Nazely Diban; Virginie Boiteux; Adeline Colin; Xavier Dauchy; Ane Urtiaga. Boron doped diamond electrooxidation of 6:2 fluorotelomers and perfluorocarboxylic acids. Application to industrial wastewaters treatment. Journal of Electroanalytical Chemistry 2017, 798, 51 -57.

AMA Style

Beatriz Gomez-Ruiz, Sonia Gómez-Lavín, Nazely Diban, Virginie Boiteux, Adeline Colin, Xavier Dauchy, Ane Urtiaga. Boron doped diamond electrooxidation of 6:2 fluorotelomers and perfluorocarboxylic acids. Application to industrial wastewaters treatment. Journal of Electroanalytical Chemistry. 2017; 798 ():51-57.

Chicago/Turabian Style

Beatriz Gomez-Ruiz; Sonia Gómez-Lavín; Nazely Diban; Virginie Boiteux; Adeline Colin; Xavier Dauchy; Ane Urtiaga. 2017. "Boron doped diamond electrooxidation of 6:2 fluorotelomers and perfluorocarboxylic acids. Application to industrial wastewaters treatment." Journal of Electroanalytical Chemistry 798, no. : 51-57.

Book chapter
Published: 22 December 2015 in Encyclopedia of Membranes
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Pervaporation (PV) is a membrane-based technology largely studied for aroma compound recovery and concentration in the food industry (Pereira et al. 2006). At least two PV pilot plants for aroma compound recovery have been built at Membrane Technology and Research (MTR) Inc., California (EEUU), and Agrotechnology & Food Innovations (A&F) in the Netherlands (Willemsen et al. 2004), and theoretical studies assessing the recovery and concentration of aroma compounds by means of PV have demonstrated the viability of this technology at industrial scale (Karlsson et al. 1998; Lipnizki et al. 2002a, b; Trifunovic et al. 2006). During the PV, the aroma compounds contained in a liquid or feed phase permeate selectively through a dense hydrophobic membrane due to the chemical potential gradient caused by a reduction of the component partial pressure in the permeate side. The aroma compounds are preferentially transported through the membrane according to their affinity to the membran ...

ACS Style

Immaculada Ortiz; Nazely Diban. Bilberry Aroma Recovery by Pervaporation. Encyclopedia of Membranes 2015, 1 -5.

AMA Style

Immaculada Ortiz, Nazely Diban. Bilberry Aroma Recovery by Pervaporation. Encyclopedia of Membranes. 2015; ():1-5.

Chicago/Turabian Style

Immaculada Ortiz; Nazely Diban. 2015. "Bilberry Aroma Recovery by Pervaporation." Encyclopedia of Membranes , no. : 1-5.

Journal article
Published: 01 April 2015 in Sustainable Production and Consumption
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María Margallo; Rubén Aldaco; Albert Barceló; Nazely Diban; Inmaculada Ortiz; Angel Irabien. Life cycle assessment of technologies for partial dealcoholisation of wines. Sustainable Production and Consumption 2015, 2, 29 -39.

AMA Style

María Margallo, Rubén Aldaco, Albert Barceló, Nazely Diban, Inmaculada Ortiz, Angel Irabien. Life cycle assessment of technologies for partial dealcoholisation of wines. Sustainable Production and Consumption. 2015; 2 ():29-39.

Chicago/Turabian Style

María Margallo; Rubén Aldaco; Albert Barceló; Nazely Diban; Inmaculada Ortiz; Angel Irabien. 2015. "Life cycle assessment of technologies for partial dealcoholisation of wines." Sustainable Production and Consumption 2, no. : 29-39.

Journal article
Published: 04 January 2015 in Current Topics in Medicinal Chemistry
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The regeneration of brain tissue is one of the major challenges in regenerative medicine due to the lack of viable grafts to support the re-growth of functional tissue after a traumatic injury. The development of biocompatible and biodegradable structures with appropriate morphology for the interaction with neural tissue is required. The objective pursued in this work is to develop a biodegradable 2D scaffold structure for neural tissue engineering. Poly(ε-caprolactone) (PCL) was the selected material due to its biocompatibility and biodegradability in the long term. PCL (15%w/w) was dissolved in N-methylpyrrolidone and the film was fabricated by phase inversion casting technique employing ethanol and isopropanol as coagulation baths. The physical structure, morphology and topography of the flat scaffolds were characterized using different techniques. The two different scaffolds presented homogeneous structure with high porosity (higher than 85%), contact angles higher than 90(o), high roughness (Ra> 0.6 μm) and superficial pore sizes of 0.7 and 1.7 μm, respectively. Permeance tests showed high water permeabilities (~350-590 mL m(-1) bar(-1) h(-1)) indicative of promising nutrients supply to the cells. Finally, in vitro human glioblastoma cells cultures after 48 hours showed good cell attachment, proliferation and penetration in the scaffolds. Detailed evaluation of the interaction between the surface morphology and the properties of the scaffolds with the cell response has been done. Thus, the PCL films herein fabricated show promising results as scaffolds for neural tissue regeneration.

ACS Style

N. Diban; Jose Ramos Vivas; S. Remuzgo-Martinez; I. Ortiz; A. Urtiaga. Poly(?-caprolactone) films with favourable properties for neural cell growth. Current Topics in Medicinal Chemistry 2015, 14, 2743 -2749.

AMA Style

N. Diban, Jose Ramos Vivas, S. Remuzgo-Martinez, I. Ortiz, A. Urtiaga. Poly(?-caprolactone) films with favourable properties for neural cell growth. Current Topics in Medicinal Chemistry. 2015; 14 (23):2743-2749.

Chicago/Turabian Style

N. Diban; Jose Ramos Vivas; S. Remuzgo-Martinez; I. Ortiz; A. Urtiaga. 2015. "Poly(?-caprolactone) films with favourable properties for neural cell growth." Current Topics in Medicinal Chemistry 14, no. 23: 2743-2749.

Research article
Published: 05 December 2014 in Industrial & Engineering Chemistry Research
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The use of “nonideal” zeolite membranes for the in situ H2O removal in a packed-bed membrane reactor (PBMR) during the synthesis of dimethyl ether (DME) allows the recovery of CO2 but unexpectedly reduces DME yield by 50% in comparison to a packed-bed reactor (PBR) as previously reported [Diban et al. Chem. Eng. J. 2013, 234, 140]. Due to the advantageous performance of PBMR, the present work aims to the theoretical analysis and optimization of the working conditions and system configuration that enhance both DME yield and CO2 recovery. Here, the previously developed mathematical model able to predict the mass transport rate of all the components present in the reactive system through zeolite membranes has been modified and accounts for the sweep gas recirculation. The influence of the sweep gas flow-rate in the range 0.06–1.80 molCOx·h–1 (laboratory scale) and sweep gas recirculation factor (0 < α < 1) has been analyzed. Sweep gas flow-rates >0.18 molCOx·h–1 favored CO2 conversion but only partial recirculation of the sweep gas promoted DME yields beyond those obtained in a PBR due to the synergism between effective H2O removal and MeOH retention in the feed side. Although energetically challenging, these results show promising prospects to apply the existing zeolite membranes for the chemical transformation of CO2 into DME on a large scale.

ACS Style

Nazely Diban; Ane M. Urtiaga; Inmaculada Ortiz; Javier Ereña; Javier Bilbao; Andrés T. Aguayo. Improved Performance of a PBM Reactor for Simultaneous CO2 Capture and DME Synthesis. Industrial & Engineering Chemistry Research 2014, 53, 19479 -19487.

AMA Style

Nazely Diban, Ane M. Urtiaga, Inmaculada Ortiz, Javier Ereña, Javier Bilbao, Andrés T. Aguayo. Improved Performance of a PBM Reactor for Simultaneous CO2 Capture and DME Synthesis. Industrial & Engineering Chemistry Research. 2014; 53 (50):19479-19487.

Chicago/Turabian Style

Nazely Diban; Ane M. Urtiaga; Inmaculada Ortiz; Javier Ereña; Javier Bilbao; Andrés T. Aguayo. 2014. "Improved Performance of a PBM Reactor for Simultaneous CO2 Capture and DME Synthesis." Industrial & Engineering Chemistry Research 53, no. 50: 19479-19487.

Journal article
Published: 10 February 2014 in Journal of Chemical Technology & Biotechnology
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Polymeric hollow fiber (HF) membranes are commercially available, i.e. microfiltration and ultrafiltration cartridges or reverse osmosis and gas separation modules, to be applied for separation purposes in industry, for instance to recover valuable raw materials or products, or for the treatment of end‐of‐pipe wastes to avoid environmental impacts, to regenerate or treat waters for reuse and for the separation of key components or clarification in food and beverage industries. They have also shown important benefits as hemodialyzers, hemodiafiltration or plasma purification devices in patients with liver or kidney damage. The good mass transport properties characterizing the polymeric HFs have opened new research areas of application in the biomedical field, such as the tissue engineering (TE) and the construction of bioartificial organs (BAO). In TE, the HFs act as scaffolds or supports and/or allow high permeance of nutrients and waste removal for cell proliferation and differentiation. In BAO, HFs are used for the fabrication of bio‐hybrid constructs that replace the damaged organs of the patient or can be used as in vitro models for therapeutic studies. This review presents the state‐of‐the‐art concerning preparation and application of HFs for TE and BAO and discusses the challenges and future perspectives of the HFs in both fields. © 2014 Society of Chemical Industry

ACS Style

Nazely Diban; Dimitrios Stamatialis. Polymeric hollow fiber membranes for bioartificial organs and tissue engineering applications. Journal of Chemical Technology & Biotechnology 2014, 89, 633 -643.

AMA Style

Nazely Diban, Dimitrios Stamatialis. Polymeric hollow fiber membranes for bioartificial organs and tissue engineering applications. Journal of Chemical Technology & Biotechnology. 2014; 89 (5):633-643.

Chicago/Turabian Style

Nazely Diban; Dimitrios Stamatialis. 2014. "Polymeric hollow fiber membranes for bioartificial organs and tissue engineering applications." Journal of Chemical Technology & Biotechnology 89, no. 5: 633-643.

Article
Published: 18 December 2013 in Macromolecular Symposia
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Nazely Diban; Suvi P. Haimi; Lydia Bolhuis-Versteeg; Sandra Teixeira; Susanna Miettinen; Andre A. Poot; Dirk W. Grijpma; Dimitrios Stamatialis. Effect of Surface Morphology of Poly(ϵ-caprolactone) Scaffolds on Adipose Stem Cell Adhesion and Proliferation. Macromolecular Symposia 2013, 334, 126 -132.

AMA Style

Nazely Diban, Suvi P. Haimi, Lydia Bolhuis-Versteeg, Sandra Teixeira, Susanna Miettinen, Andre A. Poot, Dirk W. Grijpma, Dimitrios Stamatialis. Effect of Surface Morphology of Poly(ϵ-caprolactone) Scaffolds on Adipose Stem Cell Adhesion and Proliferation. Macromolecular Symposia. 2013; 334 (1):126-132.

Chicago/Turabian Style

Nazely Diban; Suvi P. Haimi; Lydia Bolhuis-Versteeg; Sandra Teixeira; Susanna Miettinen; Andre A. Poot; Dirk W. Grijpma; Dimitrios Stamatialis. 2013. "Effect of Surface Morphology of Poly(ϵ-caprolactone) Scaffolds on Adipose Stem Cell Adhesion and Proliferation." Macromolecular Symposia 334, no. 1: 126-132.