A subway transfer station hall is crowded and complex in structure, which makes evacuation more difficult in case of a fire, but also provides more strategic options for smoke extraction. Full-scale experiments and numerical simulations are conducted to investigate the feasibility and performance of coordinated ventilation in a T-shaped transfer station hall, accounting for different fire source locations, ventilation modes, and fire shutter operations. It is found that the optimal ventilation strategy varies based on the fire location within the T-shaped configuration. For fires on the ‘T’s horizontal side, lateral airflow from longitudinal fans can effectively disrupt smoke spreading, with coordinated extraction strategies outperforming the traditional methods. However, for fires on the ‘T’s longitudinal side, horizontal fans are ineffective in controlling smoke flow, making the traditional fire shutter closure optimal. The idea of dispersing hot smoke to a reasonable degree can create better evacuation conditions for people near a fire, while creating almost no new danger zones.