A simple way of synthesis of artemisinin dimer using nitro aliphatic compounds is reported. Herein, few artemisinin monomers and dimers have been synthesized with the help of linker nitroalkanes using iron catalyst supported on polymer (Fe/SBA-15). The synthesized artemisinin shows good anticancer and antimalarial activities

An efficient and green methodology to synthesize cyclic dithiocarbamates (compounds 1-11) was developed by reaction of primary amines, CS2 and 1,2-dibromoethane or 1,4-dibromobutane, catalyzed by Triton-B (as PTC)/CS2 system. Mass spectroscopy, elemental analysis and 1H NMR are used for characterization of the synthesized compounds (1-11). This effectual green tactics give good yield of product which entails mild conditions. Compounds (1-11) were found to possess in vitro antimicrobial activities against the pathogenic bacterial and fungal strain. The microbial strains used to screen activities are Escherichia coli, Staphylococcus aureus and Candida albicans.

Heterocycles are organic compounds, the most important pharmaceutical skeleton widely distributed in nature. Many of them possess medicinal as well as pharmacological activities. Pyrroles are well-known five-member-privileged scaffolds with pharmaceutical potential. Pyrrole is the component of complex macrocycles, including porphyrins of heme and chlorophylls. Nowadays, the development of microwave-supported synthetic strategies for such biologically relevant heterocycles is an important objective. Microwave-induced pyrrole synthesis has become an environmentally benign route in organic transformation with reduced reaction time and high yields. This mini-review focuses on the eco-friendly microwave-induced synthesis of pyrroles, their derivatives, and their potential pharmacological applications, covering literature up to 2022.

Synthesis of heterocyclic scaffolds by microwave irradiation is a green and clean process. The organic transformation induced by microwave irradiation, as an alternative source of energy, has been of great interest due to the high efficiency, yield, and short reaction time with minimum by-product production. Heterocyclic compounds, an important skeleton for pharmaceuticals, are the most privileged and prevalent class of organic chemistry. They have enormous medicinal value and pharmaceutical potential. This review demonstrates the effectiveness of microwave heating for the synthesis of heterocyclic compounds. The eco-friendly microwave-induced synthesis of five-membered heterocyclic systems covering recent literature is highlighted in this article.

One of the most efficient non-conventional heating methods is microwave irradiation. In organic synthesis, microwave irradiation has become a popular heating technique as it enhances product yields and purities, reduces reaction time from hours to minutes, and decreases unwanted side reactions. Microwave-assisted organic synthesis utilizes dielectric volumetric heating as an alternative activation method, which results in rapid and more selective transformations because of the uniform heat distribution. Heterocyclic compounds have a profound role in the drug discov-ery and development process along with their applications as agrochemicals, fungicides, herbi-cides, etc., making them the most prevalent form of biologically relevant molecules. Hence, enor-mous efforts have been made to flourish green routes for their high-yielding synthesis under mi-crowave irradiation as a sustainable tool. Among the different clinical applications, heterocyclic compounds have received considerable attention as anti-cancer agents. Heterocyclic moieties have always been core parts of the development of anti-cancer drugs, including market-selling drugs, i.e., 5-fluorouracil, doxorubicin, methotrexate, daunorubicin, etc., and natural alkaloids, such as vinblastine and vincristine. In this review, we focus on the developments in the microwave-assisted synthesis of heterocycles and the anti-cancer activities of particular heterocycles.

Dithiocarbamates are organosulphur ligands and form chelate compounds with metals. Their uses are reported in the field of accelerating vulcanization, pesticide, material science, organic synthesis, etc. Recent research demonstrated the potential of metal complexes of these ligands as good antifungal, antibacterial, and antitumor agents. Dithiocarbamate complexes have also been reported to use as a plasmonic sensor, as an inhibitor of proteasome, and for antioxidant and antileishmanial activity. This brief review presents the biological activities of metal complexes of dithiocarbamate.