Background and objective: Depression is frequent in Parkinson's disease (PD), but it is unclear how mood changes and impacts patient's quality of life (QoL) over time. Our objective was to analyze the frequency of depression and mood changes in people with PD (PwP) over 5 years of follow-up, comparing it with a control group, as well as its relationship with the patients' QoL. Patients and Methods: PwP and healthy controls (HC) recruited from the COPPADIS cohort from January/2016 to November/2017 were included in this 5-year follow-up study. Mood was assessed by the Beck Depression Inventory II (BDI-II), and participants were classified as having major depression, minor depression, subthreshold depression, or non-depression at baseline and at 2, 4, and 5 years of follow-up. Correlation analysis and linear regression models were applied. Results: The BDI-II total score increased from 8.1 ± 6.2 at baseline to 10.3 ± 8.1 at the 5-year follow-up visit in PwP (p< 0.0001) but not in HC (from 4.1 ± 5.2 to 4.0 ± 5.7 [p=0.896]). The prevalence of depression remained around 50–54% in the PwP group and 21–25% in the HC group throughout the follow-up period, but the mood state showed variability for each patient between visits. Patients´ QoL was associated with the depressive state throughout the entire follow-up period (p< 0.0001). Worsening QoL, sleep, longer disease duration, and an increase in neuropsychiatric symptoms were identified as independent factors associated with a worsening of mood over time in PwP (N=348). Conclusion: Mood changes over time in PwP and are associated with QoL.

Introduction: Valle-Inclán’s Bohemian Lights is the inaugural work of the esperpento, a literary genre that was born with the intention of offering distorted images of reality as a way of accessing it in a reflexive way. Material and Methods: Critical reading of the editio princeps of the work to analyze its neurological content. Results: The character of Max Estrella, inspired by the figure of Alejandro Sawa, would not meet the criteria for encephalitis. The diagnoses of Charles Bonnet syndrome and death due to stroke are more likely. The characters at the wake discuss the differential diagnosis between death and catalepsy, and one of them suffers a non-epileptic event. Conclusions: Bohemian Lights reflects different social, political and cultural aspects contemporary to the author. Health and disease are also addressed, with a preponderant role for neurology.