Gleeble-3800 thermal simulation testing machine was adopted to investigate the evolution laws of microstructure and properties in the coarse-grained heat-affected zone (CGHAZ) of pipeline steels with different Cr mass fractions (0.2, 0.5, 0.8 wt.%) under welding heat inputs ranging from 8 kJ/cm to 20 kJ/cm. Combined with optical microscopy, scanning electron microscopy and electron backscatter diffraction, the coupled influencing mechanism of heat input and Cr content on the properties of CGHAZ was systematically analyzed. The results show that as the Cr content increases, the range of valid welding heat input for maintaining satisfactory CGHAZ impact toughness gradually narrows with increasing Cr mass fraction of the steel. Specifically, the 0.2Cr experimental steel maintains high toughness under a thermal input ranging from 8 to 20 kJ/cm, the 0.5Cr experimental steel exhibits relatively high toughness in the range 8 to 13 kJ/cm, while the 0.8Cr experimental steel shows high toughness only at 15 kJ/cm. The coupled effect of weld heat input and Cr content on CGHAZ properties originates from a combination of microstructural composition types, phase fractions, substructures, and grain sizes. Increasing the heat input and Cr content leads to a reduction in the bainite ferrite with superior toughness and an increase in the large-sized granular bainite with inferior toughness. Meanwhile, the effective grain size of the overall microstructure first decreases and then rises. Grain coarsening and an increased fraction of Martensitic/Austenitic (M/A) constituent are the key factors responsible for the deterioration of CGHAZ toughness in deep-sea oil and gas transportation pipeline steel.