Inequality theory has attracted considerable attention from scientists because it can be used in many fields. In particular, Hermite–Hadamard and Simpson inequalities based on convex functions have become a cornerstone in pure and applied mathematics. We deal with Simpson’s second-type inequalities based on coordinated convex functions in this work. In this paper, we first introduce Simpson’s second-type integral inequalities for two-variable functions whose second-order partial derivatives in modulus are convex on the coordinates. In addition, similar results are acquired by considering that powers of the absolute value of second-order partial derivatives of these two-variable functions are convex on the coordinates. Finally, some applications for Simpson’s $3/8$ cubature formula are given.