Objective: The objective of this study was to evaluate different quality criteria of Apis mellifera bee honey from the municipality of Llera in the central-southern region of the state of Tamaulipas, Mexico. Theoretical Framework: In the state of Tamaulipas, A. mellifera honey is produced, considered one of the most important beekeeping products. This activity reflects the economic strengthening and well-being of this area and it is fundamental for ecosystem’s survival and biodiversity. Method: The methodology applied for this study focused on the selection of six samples from different apiaries in the municipality of Llera, using standardized techniques for the corresponding analyses. Results and Discussion: Results showed that most of the honeys meet quality standards. Values ​​were expressed as mean values ​​± SD. Data were subjected to an analysis of variance and Tukey’s test, and statistical significance was established at p≤0.05. Research Implications: The sampling of honey was limited by the availability of beekeepers; on the other hand, some honey crystallized in less time than others. Originality/Value: The study allowed us to evaluate the quality of honey, which guarantees having a high-quality product for marketing.