Lee SY, et al. Allergy Asthma Immunol Res. 2018 Jul;10(4):354-362. https://doi.org/10.4168/aair.2018.10.4.354

The roles of gut microbiota on the natural course of atopic dermatitis (AD) are not yet fully understood. We investigated whether the composition and function of gut microbiota and short-chain fatty acids (SCFAs) at 6 months of age could affect the natural course of AD up to 24 months in early childhood. Fecal samples from 132 infants were analyzed using pyrosequencing, including 84 healthy controls, 22 transient AD and 26 persistent AD subjects from the Cohort for Childhood Origin of Asthma and Allergic Diseases (COCOA) birth cohort. The functional profile of the gut microbiome was analyzed by whole-metagenome sequencing. SCFAs were measured using gas chromatography-mass spectrometry. Low levels of Streptococcus and high amounts of Akkermansia were evident in transient AD cases, and low Clostridium, Akkermansia and high Streptococcus were found in children with persistent AD. The relative abundance of Streptococcus positively correlated with scoring of AD (SCORAD) score, whereas that of Clostridium negatively correlated with SCORAD score. The persistent AD group showed decreased gut microbial functional genes related to oxidative phosphorylation compared with healthy controls. Butyrate and valerate levels were lower in transient AD infants compared with healthy and persistent AD infants. Compositions, functions and metabolites of the early gut microbiome are related to natural courses of AD in infants.

Jeon YH, et al. J Korean Med Sci. 2019 Mar;34(13):e106. https://doi.org/10.3346/jkms.2019.34.e106

Kang MJ, et al. Allergy Asthma Immunol Res. 2021 May;13(3):404-419. https://doi.org/10.4168/aair.2021.13.3.404