This study aimed to establish a strong regression model by revealing the preoperative predictive factors for sentinel lymph node (SLN) positivity in patients with early stage breast cancer (ESBC). In total, 445 patients who underwent SLN dissection for ESBC were included. All data that may be potential predictors of SLN positivity were retrospectively analyzed. Tumor size >2 cm, human epidermal growth factor receptor 2 (HER2) + status, lymphovascular invasion (LVI), palpable tumor, microcalcifications, multifocality or multicentricity, and axillary ultrasonographic findings were defined as independent predictors of SLN involvement. The area under the receiver operating characteristic (ROC) curve (AUC) values were 0.797, 0.808, and 0.870 for the Memorial Sloan-Kettering Cancer Center (MSKCC) nomogram, MD Anderson Cancer Center (MDACC) nomogram, and our regression model, respectively (P < .001). The recent model for predicting SLN status in ESBC was found to be stronger than existing nomograms. Parameters not included in current nomograms, such as palpable tumors, microcalcifications, and axillary ultrasonographic findings, are likely to make this model more meaningful.

Background: Obesity is a major public health problem, with increasing rates noted globally. This study aimed to compare the surgical outcomes of total thyroidectomy in normal-weight, overweight, and obese patients. Methods: We retrospectively reviewed 601 patients who underwent thyroidectomy between 2009 and 2016. Recorded data included patient demographics, preoperative diagnosis, preoperative biochemical markers, length of stay, operative time, postoperative histopathologic diagnosis, and complications. Patients were categorized into 3 groups based on body mass index: group A (normal weight), group B (overweight), and group C (obese). Results: Of the 415 patients who underwent total thyroidectomy, 81 patients (19.5%) were in group A, 164 patients (39.5%) were in group B, and 170 patients (41%) were in group C. No statistically significant differences were observed among the groups in terms of age, comorbid illness, preoperative biochemical markers, or postoperative diagnosis, except for gender distribution. Similarly, no differences were noted among the groups in terms of postoperative length of stay or operative time (P>0.05). The incidence of postoperative complications did not significantly vary among groups (P>0.05). Conclusions: Our findings suggest that obese and overweight patients did not experience higher rates of complications while undergoing total thyroidectomy relative to their normal-weight counterparts.