Coriander (Coriandrum sativum L.) is a very popular medicinal plant that belongs to Apiaceae family in taxonomic classification, which is widely used as a spice and also in pharmacy and in food industries. The plant used in folk medicine, especially in Egypt, it has been known as one of the earliest spices. Coriander (Cilantro, Kişniş, Chinese parsley, Coriandrum sativum) is extensively recognized in almost every recipe. The genus Coriander was represented in Flora of Turkey by two different species called C. sativum L. and C. tordylium (Fenzl) Bornm. It is mainly cultivated for the seeds (fruits) that contain essential oil, fatty acids, coumarins, flavonoids, and polyphenols. Nowadays, the fruits exhibit internally carminative, spasmolytic, and galactagogic effects in many disorders. The use of coriander in different forms includes a wide range of fresh and dried herbs. The current section focuses on coriander oil in different forms, including the plant, its terpenoid profile, and all the miracle effects of coriander together with future prospects.
1 January 2020 in Anais da Academia Brasileira de Ciências
Seseli L. is an important genus of the Apiaceae family, with a large number of aromatic species. It is used in traditional medicine extensively, but there is quite limited information on their phytochemicals and biological activities. Seseli petraeum M. Bieb. grows in Northern Anatolia, and there are no phytochemical studies on this species. In the present study, we aimed to investigate the effect of the extracts of S. petraeum on A549 lung cancer cell proliferation. For this purpose, the antiproliferative effect was determined via MTT assay, and the extracts obtained from the root of S. petraeum showed a significant inhibitory effect on cell proliferation. The hexane extract of the root exhibited potent inhibition on A549 cancer cell growth at the 24th hour with 3.432 mg/mL IC50 value. The results also showed that the hexane extract had displayed cytotoxic effect through an arrest at the G0/G1 phase of the cell cycle and induced apoptosis as well as DNA damage of A549 cells. Consequently, this study demonstrated the antiproliferative potential of the extracts from S. petraeum, especially hexane extract from the roots. Further studies are required to identify the mechanisms underlying these effects.
1 April 2020 in Turkish Journal of Pharmaceutical Sciences
In the present study, the antioxidant potency of ethyl acetate (AcOEt) and methanol (MeOH) extracts from the aerial parts of Seseli L. species was investigated for the first time. Seseli species L. such as Seseli andronakii Woronow ex Schischk., S. campestre Besser, S. corymbosum Boiss. & Heldr., S. gummiferum subsp. gummiferum Pall. ex Sm., S. hartvigii Parolly & Nordt, S. libanotis (L.) W.Koch, S. petraeum M.Bieb., S. peucedanoides (M.Bieb.) Koso-Pol., S. resinosum Freyn & Sint., and S. tortuosum L. growing in Turkey were collected and evaluated for their antioxidant capacity by using 1.1-diphenyl-2-picrylhydrazyl (DPPH) radical scavenging and lipid peroxidation (LPO) inhibition methods. The highest activities as a scavenger of DPPH radicals were found in the AcOEt extracts of S. peucedanoides (M.Bieb.) Koso-Pol (IC50=0.49 mg/mL), and S. libanotis (IC50=0.75 mg/mL); α-tocopherol was used as a positive control. On the other hand, in the LPO assay, the highest activities were determined in AcOEt and MeOH extracts (at 5 mg/mL) of S. tortuosum and S. libanotis (84-94%). This report gives important information about the antioxidant capacity of Seseli L. species. This research on antioxidant capacity proves that the use of some species used in Eastern Anatolia (in salads) is correct. With this screening study performed in Seseli L. species growing in Turkey, in the future, it is planned to isolate antioxidant compounds from the most active strains of Seseli L.