Esophageal cancer surgery is associated with high morbidity and mortality, and anastomotic leakage remains a critical determinant of outcomes. Although thoracic inlet size has been linked to complications in retrosternal reconstruction, its role in posterior mediastinal reconstruction is unclear. In this retrospective study, 67 patients who underwent esophagectomy with posterior mediastinal reconstruction were analyzed. Thoracic inlet measurements were obtained from preoperative computed tomography. Postoperative complications occurred in 29.9% of patients, anastomotic leakage (AL) in 14.9%, and overall 30-day postoperative mortality in 13.4%. The thoracic inlet area (TIA) was significantly lower in non-survivors than in survivors (513.5 vs. 703.3 mm², p = 0.012). Anastomotic leakage was markedly more frequent among non-survivors (66.7% vs. 6.9%). In multivariable analysis adjusted for age and sex, thoracic inlet area remained associated with postoperative mortality; however, the findings should be interpreted cautiously because of the limited sample size and retrospective design. These findings suggest a possible association between thoracic inlet geometry and postoperative outcomes in posterior mediastinal reconstruction; however, larger prospective multicenter studies are required before definitive clinical conclusions can be drawn.

Background and Objectives: Sustained weight loss remains one of the greatest challenges in obesity management, as many individuals experience weight regain after initial treatment success. Although early weight loss has consistently been associated with greater overall weight reduction, its relationship with subsequent weight regain in routine clinical practice remains insufficiently characterized. This study examined the association between early weight loss and clinically significant weight regain among adults participating in a lifestyle-based obesity management program. Materials and Methods: We conducted a retrospective cohort study of adults receiving structured lifestyle-based obesity treatment at a tertiary care obesity clinic. Early weight loss was defined as the percentage reduction in body weight from baseline to the routinely scheduled third-month follow-up measurement. Clinically significant weight regain at one year was defined as regaining at least 50% of the maximum weight lost from baseline to nadir weight, expressed as the weight regain ratio (WRR ≥ 0.50). Logistic regression was used to examine the association between early weight loss and subsequent weight regain after adjustment for age, baseline body mass index, and baseline body weight. Sensitivity analyses included a female-only model, an alternative weight regain definition (WRR ≥ 0.25), and Firth-penalized logistic regression. Results: Among 79 participants with complete follow-up data, 9 (11.4%) experienced clinically significant weight regain at one year. Conclusions: Greater early weight loss was independently associated with lower odds of clinically significant weight regain (adjusted odds ratio 0.784, 95% confidence interval 0.646–0.950; p = 0.013). The association remained consistent in the female-only analysis and in the Firth-penalized logistic regression. When clinically significant weight regain was alternatively defined as WRR ≥ 0.25, the association remained in the same direction but did not reach statistical significance. Age, baseline body mass index, and baseline body weight were not significantly associated with the outcome.