Soil contamination with heavy metals poses a serious threat to plants, their productivity and food safety. Plant growth regulators offer an environmentally friendly strategy to reduce metal uptake and mitigate plant stress responses. The study was conducted in 2024 at the Zhalyn Scientific and Production Technical Center to assess the effect of plant growth regulators on the accumulation of heavy metals in soil and wheat plants. Wheat seeds were pre-soaked in plant extracts, then the seeds were sown in plots. On the 7th and 14th days, plant samples were taken for analysis. Heavy metal concentrations in roots and shoots were quantified by atomic absorption spectrometry. The results showed that alfalfa extract most effectively reduced the accumulation of heavy metals in both roots and shoots. Pre-treatment with plant extracts significantly reduced the absorption of toxic metals, in particular, cadmium and copper. A noticeable effect was observed when using 0.75% alfalfa extract, which reduced the content of heavy metals up to 100 times in roots and up to 106 times in shoots.