Currently, there is no comprehensive bibliometric study in the literature on Crohn’s disease (CD). The aim of this study was to analyze articles published on CD using bibliometric and statistical methods. The aim was to identify current research trends, show global productivity, and determine important players such as countries, journals, institutions, and authors. A total of 16,216 articles published on CD between 1980 and 2022 were analyzed using various statistical and bibliometric methods. Bibliometric network visualization maps were used to perform trend topic analysis, citation analysis, and international collaboration analysis. Spearman’s correlation coefficient was used for correlation analysis. The top 3 contributing countries to the literature were the United States of America (USA) (n = 4344, 26.7%), the United Kingdom (UK) (n = 2036, 12.5%) and Germany (n = 1334, 8.2%). The most active institutions were Udice French Research Universities (n = 696), Assistance Publique Hopitaux Paris (n = 570), and Institut National de la Sante et de la Recherche Medicale Inserm (n = 479). The most productive journals were Inflammatory Bowel Diseases (n = 1100), Journal of Crohn’s & Colitis (n = 579), and Gut (n = 510). The most prolific author was Colombel JF. (n = 290). The most frequently researched topics from past to present included infliximab, ulcerative colitis, surgery, pediatrics, adalimumab, magnetic resonance imaging, inflammation, perianal CD/perianal fistula, azathioprine, magnetic resonance enterography, small bowel, stricture/strictureplasty, recurrence, therapy/treatment, ustekinumab, mucosal healing, biomarkers, fistula, quality of life, ultrasonography, epidemiology, capsule endoscopy, laparoscopic surgery/laparoscopy, endoscopy, disease activity, postoperative recurrence, and the Nucleotide Binding Oligomerization Domain Containing 2 gene. We have seen an exponential increase in worldwide publications on CD. In recent years, the major research topics related to CD have been ustekinumab, vedolizumab, fecal calprotectin, therapeutic drug monitoring, biologics, biomarkers, exclusive enteral nutrition, microbiome/microbiota, magnetic resonance enterography, anti-TNF, postoperative complications, and mucosal healing. We determined that countries with large economies, particularly the United States, United Kingdom, Germany, France, Canada, Italy, Japan and China, have taken the lead in research contributions to the development of CD literature.

Preventing relapses in addiction and related factors are still being investigated. There is inadequate data, specifically, on the effects of expressed emotion (EE) among key relatives of patients w...

Aim: Psychobiotics have become a popular topic in recent years both on social media and in academia. The effects of individuals' diets and the probiotic supplements they use on their mental state have made psychobiotics a subject of curiosity. Our aim in this research is to evaluate the content of YouTube videos about psychobiotics. Materials and Methods: On 13/12/2023, the content of the first 50 english videos related to psychobiotics on YouTube was examined for quality and reliability and was independently evaluated by 2 separate medical professionals. Data such as likes, number of views, upload dates and uploaders of the videos were recorded. The content quality of the videos was recorded by calculating the DISCERN score and Global Quality Index score (GQS). Results: The mean duration of YouTube videos about psychobiotics was 14.35 minutes. The mean GQS and modified DISCERN scores of the videos were 3.70 and 3.87, respectively. The evaluation results of two independent medical professionals who watched the videos showed a high positive correlation in terms of both GQS and DISCERN scores (r: 0.905, r: 0.908). The duration, number of likes and daily view counts of professional videos were significantly higher (p :0.001). 62% of the videos were uploaded by health channels, 28% by healthcare professionals and 10% by other individuals. GQS (p:0.005) and DISCERN (p:0.007) scores of videos uploaded by health professionals and health channels were significantly higher than others. Conclusion: Since psychobiotics is known as a newly popular term among the public and in the academic field, it has been observed that YouTube videos in this field are relatively new, uploaded by more professional channels compared to other subjects, and have more satisfactory content than other fields in terms of quality and content. However, since the number of videos is low compared to more publicly known topics and it is a relatively new topic, it may be beneficial to increase the number and promotion of professional videos to increase society's knowledge about psychobiotics.

The role of human microbiota in mental health and the underlying mechanisms of psychobiotics, which can modulate mood and behavior through the microbiota–gut–brain axis, has been a focus of scientific scrutiny. This work presents a bibliometric analysis to uncover research trends and insights in psychobiotics literature. The Clarivate Analytics Web of Science database served as the source for articles and reviews on psychobiotics spanning the years 2012 to 2023. Bibliometric network visualization and graphing were conducted using VOSviewer, Microsoft Excel for Windows 10, and Datawrapper software. A total of 348 publications were included, and it has been determined that the number of publications and citations shows an increasing trend from 2012 to 2023. The most active authors on psychobiotics, in order, were Dinan TG, Cryan JF, and Tsai YC. The most active organizations have been identified as University College Cork, National Yang Ming Chiao Tung University, and Bened Biomedical Co. Ltd. The most active countries in psychobiotic research were China, Ireland, and United States of America, while the most active journals were Nutrients, International Journal of Molecular Sciences, and Probiotics and Antimicrobial Proteins. The most commonly used keywords were “psychobiotics,” “probiotics,” and “gut–brain axis.” This bibliometric analysis has revealed the growing academic interest in psychobiotics, indicating that the relationship between gut microbiota and mental health will increasingly be supported by scientific evidence in the years ahead.

Giriş ve Amaç: Helicobacter pylori tüm dünyada ve Türkiye'de en yaygın kronik enfeksiyon etkenidir ve ülkemizdeki prevalansı %80'ler civarındadır. Öncelikle mide mukozasına tutunarak çeşitli gastroduodenal hastalıklara yol açmaktadır. Peptik ülser, gastrik MALT lenfoma, gastrik adenokanser gibi hastalıkları artırdığı bilinmekle birlikte, astım, eozinofilik özofajit ve çölyak hastalığı gibi bazı hastalıklara karşı da koruyucu olabileceği düşünülmektedir. Biz de bu çalışmamızda kliniğimizde takipli çölyak hastalarında Helicobacter pylori sıklığını değerlendirmeyi amaçladık. Gereç ve Yöntem: Çalışmaya histolojik inceleme ile tanı almış 90 çölyak hastası dahil edildi. Kontrol grubu olarak herhangi bir nedenle üst gastrointestinal sistem endoskopileri yapılarak biyopsileri yapılmış 108 hasta alındı. Hasta ve kontrol gruplarına ait veriler retrospektif olarak incelendi. Bulgular: Çölyak hastaları arasında Helicobacter pylori 90 hastadan 37’sinde (%41.1) pozitif, kontrol grubunda 108 hastadan 63’ünde (%58.3) pozitif saptandı. Çölyak hasta grubunda Helicobacter pylori sıklığı kontrol grubuna oranla anlamlı olarak daha azdı (p: 0.016). Sonuç: Çölyak hastalığı olanlarda Helicobacter pylori sıklığı literatür verileriyle de uyumlu olarak olmayanlara göre anlamlı düzeyde düşük saptanmıştır. Bu durum Helicobacter pylori varlığının çölyak hastalığı üzerine koruyucu etkileri olabileceği yönündeki fikirleri desteklemektedir. Bu ilişkinin netleştirilmesi ve olası mekanizmaların belirlenebilmesi için ileri çalışmalara halen ihtiyaç duyulmaktadır.

Background/Aim: Melatonin is a cytoprotective hormone with antioxidant activity and also mediates regulatory effects that inhibit tumor proliferation and angiogenesis. This study aimed to evaluate serum melatonin levels and sleep quality in patients with newly diagnosed colorectal cancer (CRC) compared with controls and to investigate whether melatonin could serve as a potential biomarker. Materials and Methods: A total of 71 participants (36 CRC, 35 controls) were included. Blood samples were obtained between 01:00- 02:00 am and serum melatonin was measured using a high-sensitivity (ELISA) Enzyme-Linked Immunosorbent Assay kit. Sleep quality was assessed with the Pittsburgh Sleep Quality Index (PSQI) and sleep apnea risk was determined by the STOP-Bang questionnaire. Group comparisons were performed, followed by multivariable logistic regression and receiver-operating characteristic analysis. Results: Colorectal cancer patients had significantly lower nocturnal serum melatonin concentrations (131.1 Å} 35.5 vs. 194.8 Å} 50.8 pg/ mL, P < .001) and higher PSQI scores (5.6 Å} 3.1 vs. 5.1 Å} 3.0, P = .028). In multivariable analysis, melatonin remained the only independent predictor of CRC (OR = 0.952, 95% CI: 0.929-0.976, P < .001). Receiver-operating characteristic analysis identified a melatonin threshold of ~150 pg/mL, discriminating CRC patients from controls with 75% sensitivity and 91.4% specificity (AUC = 0.877). Conclusion: Although cancer patients and the control group showed comparable obstructive sleep apnea risk, sleep quality was poorer, and melatonin levels were significantly lower in the cancer group. Melatonin assessment can complement traditional risk stratification and may provide new insights into the interplay between circadian biology, sleep, and colorectal carcinogenesis. Cite this article as: Durak I, Durak B, Duzenli T, et al. Nocturnal melatonin deficiency in colorectal cancer: independent predictive value beyond sleep quality. Turk J Gastroenterol. Published online February 23, 2026. doi: 10.5152/tjg.2026.25808.