Background/Objectives: Sexually transmitted infections (STIs) are resurgent globally, yet sub-national epidemiological data from Romania remain sparse. This study characterizes long-term STI trends in Galați County (population ~500,000) and examines whether observed morbidity patterns reflect transmission dynamics or surveillance system performance. Methods: Retrospective analysis of all notified STI cases in Galați County, 2017–2025 (nine years; n = 253), from the County Public Health Directorate surveillance database. Data included demographics, clinical stage, detection route, and temporal trends. Quasi-Poisson regression with a population offset estimated the annual change in notification rates; standardized morbidity ratios (SMR) compared local to national levels (2021–2024). Results: Over nine years, 253 cases were notified: 204 syphilis (80.6%), 49 gonorrhea (19.4%), and no chlamydia. Notification rates declined across 2017–2025 (rate ratio per year = 0.87; 95% CI 0.78–0.97; p = 0.014), reached a trough in 2020 and recovered partially thereafter, a pattern that may reflect variation in case detection, although testing volumes were not available to confirm this. Over 2021–2024, syphilis notification rates exceeded national levels in both males (SMR = 2.35; 95% CI 1.79–3.03; p < 0.0001) and females (SMR = 1.76; 95% CI 1.15–2.57; p = 0.011). Primary-stage disease was recorded in 13 of 204 syphilis cases (6.4%); antenatal screening identified 32 maternal infections over nine years with zero congenital syphilis notifications. Conclusions: The notification pattern is compatible with an important role of case detection, in particular the contrast between structured antenatal screening and opportunistic detection pathways, but testing and outcome data are needed to confirm this interpretation.

Background/Objectives: Oral structural and functional impairment and depressive outcomes frequently coexist in older adults, but the strength and interpretation of their association remain uncertain. This systematic review and meta-analysis evaluated whether poorer oral status or function is associated with depressive outcomes in older populations. Methods: Six databases were searched for observational studies published from 1 January 2016 to 5 January 2026, with an update on 19 April 2026. Eligible studies examined oral impairment as the exposure and depressive outcomes as the endpoint in older adults. Risk of bias was assessed using Newcastle–Ottawa criteria and certainty using GRADE. Comparable adjusted odds ratios (ORs) were pooled using random-effects meta-analysis with restricted maximum likelihood and Hartung–Knapp adjustment; non-comparable metrics were synthesized separately. Results: Thirty studies were included; fifteen contributed to the primary OR meta-analysis. In the primary model, poorer oral status or function was associated with higher odds of adverse depressive outcomes (OR = 1.61, 95% CI: 1.31–1.99), although between-study heterogeneity was substantial (I² = 88.1%). In the trim-and-fill sensitivity analysis, the pooled estimate decreased to OR = 1.29 (95% CI: 0.99–1.69; p = 0.0584) and no longer reached conventional statistical significance. The certainty of the primary evidence was very low. Conclusions: Poorer oral structural or functional status is associated with worse depressive outcomes in older adults, but the magnitude is heterogeneous and sensitive to small-study-effect assumptions. The evidence remains observational and of very low certainty and should be interpreted as hypothesis-generating rather than causal or treatment evidence.