Purpose: To evaluate the effect of cone-beam computed tomography (CBCT) on radiation exposure, procedure time, and contrast media (CM) use in prostatic artery embolization (PAE). Materials and Methods: Seventy-eight patients were enrolled in this retrospective, single-center study. All patients received PAE without (group A; n = 39) or with (group B; n = 39) CBCT. Total dose-area product (DAP_total; Gycm²), total entrance skin dose (ESD_total; mGy), and total effective dose (ED_total; mSv) were primary outcomes. Number of digital subtraction angiography (DSA) series, CM use, fluoroscopy time, and procedure time were secondary outcomes. PAE in group A was performed by a single radiologist with 15 years experience, PAE in group B was conducted by four radiologists with 4 to 6 years experience. Results: For groups A vs. B, respectively, median (IQR): DAP_total 236.94 (186.7) vs. 281.20 (214.47) Gycm²(p = 0.345); ED_total 25.82 (20.35) vs. 39.84 (23.75) mSv (p = < 0.001); ESD_total 2833 (2278) vs. 2563 (3040) mGy(p = 0.818); number of DSA series 25 (15) vs. 23 (10)(p = 0.164); CM use 65 (30) vs. 114 (40) mL(p = < 0.001); fluoroscopy time 23 (20) vs. 28 (25) min(p = 0.265), and procedure time 70 (40) vs.120 (40) min(p = < 0.001). Bilateral PAE was achieved in 33/39 (84.6%) group A and 32/39 (82.05%) group B(p = 0.761), all other patients received unilateral PAE. There were no significant differences between clinical parameters and origins of the prostatic arteries (PA) (p = 0.206–1.00). Conclusion: Operators with extensive expertise on PAE may not benefit from addition of CBCT to DSA runs, whereas for operators with less expertise, CBCT when used alongside with DSA runs increased the overall radiation exposure.

Athanasios Krassas, M.D., FECTS., Ioannis Diamantis, M.D., Ioannis Karampinis, M.Sc., Stefani Vgenopoulou, M.D., Panagiotis Misthos, M.D., Ph.D.. Korean J Thorac Cardiovasc Surg -0001;0:. https://doi.org/10.5090/kjtcs.20.116

Background: Human respiratory exposure to microplastics (MPs) has recently been demonstrated, but their distribution within thoracic tissues and association with lung malignancy remain poorly characterised. We investigated the presence, burden, morphology, and spectroscopic characteristics of MPs in thoracic tissue specimens and their relationship with lung malignancy. Methods: In this prospective observational study, 50 adults undergoing diagnostic thoracic surgical procedures for suspected lung malignancy were enrolled. Lung, pleural, and mediastinal lymph node specimens underwent contamination-controlled processing, microscopy, and representative particle analysis by confocal micro-Raman spectroscopy. Associations between MPs and clinicopathological variables were analysed. Results: Sixty-two morphologically identified microplastic particles were detected in 50 specimens, with MPs detected in 32 patients (64%). Fragments accounted for 97% of particles, with a median burden of one particle per specimen (IQR, 2). MP detection was significantly more frequent in patients with primary lung malignancy than in patients without primary lung malignancy, including those with metastatic malignancy and benign disease (81.8% vs. 50.0%, p = 0.020), who also exhibited a higher tissue MP burden (p = 0.024). Primary lung malignancy remained independently associated with MP detection after adjustment for age and smoking exposure (OR 4.09, 95% CI 1.06–15.79; p = 0.041). Particle morphology varied by biopsy site, with significantly smaller particles identified in mediastinal lymph nodes (p = 0.006). Synthetic anthropogenic spectral signatures were identified in 71% of particles. Conclusions: MPs are frequently present in human thoracic tissues and are associated with primary lung malignancy. Compartment-specific particle characteristics suggest distinct patterns of respiratory MP deposition and retention, supporting multicentre mechanistic studies.