Human-robot co-transportation allows for a human and a robot to perform an object transportation task cooperatively on a shared environment. This range of applications raises a great number of theoretical and practical challenges arising mainly from the unknown human-robot interaction model as well as from the difficulty of accurately model the robot dynamics. In this article, an adaptive impedance controller for human-robot co-transportation is put forward in task space. Vision and force sensing are employed to obtain the human hand position, and to measure the interaction force between the human and the robot. Using the latest developments in nonlinear control theory, we propose a robot end-effector controller to track the motion of the human partner under actuators' input constraints, unknown initial conditions, and unknown robot dynamics. The proposed adaptive impedance control algorithm offers a safe interaction between the human and the robot and achieves a smooth control behavior along the different phases of the co-transportation task. Simulations and experiments are conducted to illustrate the performance of the proposed techniques in a co-transportation task.

The identification and validation of drug targets are crucial in biomedical research and many studies have been conducted on analyzing drug target features for getting a better understanding on principles of their mechanisms. But most of them are based on either strong biological hypotheses or the chemical and physical properties of those targets separately. In this paper, we investigated three main ways to understand the functional biomolecules based on the topological features of drug targets. There are no significant differences between targets and common proteins in the protein-protein interactions network, indicating the drug targets are neither hub proteins which are dominant nor the bridge proteins. According to some special topological structures of the drug targets, there are significant differences between known targets and other proteins. Furthermore, the drug targets mainly belong to three typical communities based on their modularity. These topological features are helpful to understand how the drug targets work in the PPI network. Particularly, it is an alternative way to predict potential targets or extract nontargets to test a new drug target efficiently and economically. By this way, a drug target’s homologue set containing 102 potential target proteins is predicted in the paper.

With the more extensive application of flexible robots, the expectation for flexible manipulators is also increasing rapidly. However, the fast convergence will cause the increase of vibration amplitude to some extent, and it is difficult to obtain vibration suppression and satisfactory transient performance at the same time. In order to deal with the problem, a fixed-time learning control method is proposed to realize the fast convergence. The constraint on system outputs, system uncertainty, and input saturation is addressed under the fixed-time convergence framework. A novel adaptive law for neural networks is integrated into the backstepping method, which enhances the learning rate of neural networks. The imposed constraint on the vibration amplitude is guaranteed by using the barrier Lyapunov function (BLF). Moreover, the chattering problem is addressed by approximating the sign function smoothly. In the end, some simulations have been carried out to show the effectiveness of the proposed method.

Federated learning (FL) is an emerging distributed machine learning (ML) framework that operates under privacy and communication constraints. To mitigate the data heterogeneity underlying FL, clustered FL (CFL) was proposed to learn customized models for different client groups. However, due to the lack of effective client selection strategies, the CFL process is relatively slow, and the model performance is also limited in the presence of nonindependent and identically distributed (non-IID) client data. In this work, for the first time, we propose selecting participating clients for each cluster with active learning (AL) and call our method active client selection for CFL (ACFL). More specifically, in each ACFL round, each cluster filters out a small set of clients, which are the most informative clients according to some AL metrics [e.g., uncertainty sampling, query-by-committee (QBC), loss], and aggregates only its model updates to update the cluster-specific model. We empirically evaluate our ACFL approach on the public MNIST, CIFAR-10, and LEAF synthetic datasets with class-imbalanced settings. Compared with several FL and CFL baselines, the results reveal that ACFL can dramatically speed up the learning process while requiring less client participation and significantly improving model accuracy with a relatively low communication overhead.

Coronavirus disease 2019 has brought a great challenge to the supply of daily necessities and medical items for home-quarantined people. Considering the unmanned operation, agility and use of clean energy of drones, we propose a novel truck-and-drone coordinated delivery system that does not require direct human contact during the delivery process. All final deliveries are completed by the drone while the truck acts as a movable charging station and a carrier, so that the contagion risks are reduced. Moreover, we spilt the whole delivery problem into the customer clustering problem and the routing problems of both the truck and the drone. An encoder-decoder framework combined with reinforcement learning is created to solve the routing problems without handcrafted designed heuristics. We design the different problem contexts specific to the truck routing problem and the drone routing problem. The experimental results show the proposed approach has good generality and can consequently be applied to problems of different scales with high time efficiency.

In this article, vibration abatement problems of a riser system with system uncertainty, input deadzone, and output constraint are considered. For obtaining better control precision, a boundary control law is constructed by employing the backstepping method and Lyapunov’s theory. The output constraint is guaranteed by utilizing a barrier Lyapunov function. Adaptive neural networks are designed to cope with the uncertainty of the riser and compensate for the effect caused by the asymmetric deadzone nonlinearity. With the designed controller, the output constraint is satisfied, and the system stability is guaranteed through Lyapunov synthesis. In the end, numerical simulation results are provided to display the performance of the developed adaptive neural network boundary control law.