Seroma is the most common wound complication due to dead space remaining after mastectomy and axillary dissection. Seroma formation, which causes pain and tension, together with the limitations of shoulder and arm movements, can cause wound healing problems that can progress to wound dehiscence and flap necrosis. The aim of our study was to investigate the effects of continuous drainage and negative pressure wound therapy (NPWT) in breast cancer patients with refractory postmastectomy seroma. This retrospectively designed study was conducted with 27 patients who were referred to our center between 2018 and 2021 due to refractory seroma after mastectomy. The inclusion criteria of the study were the cases who were planned minimally invasive debridement and NPWT due to having refractory seroma formation with at least 200 cc and having interventions more than 1 month after modified radical mastectomy (MRM), despite conventional treatment methods. All patients’ demographics, disease stage, history of possible neoadjuvant therapy, comorbidities, body mass index (BMI), number of wound dressings with NPWT, and total amount of NPWT accumulation were enrolled and compared statistically. Twenty-seven patients included in the study underwent continuous drainage after debridement, and 5 (3–9) dressings were treated with NPWT. None of the patients experienced complications after debridement and NPWT administration. In refractory seroma cases seen after postmastectomy, NPWT especially for the management of debridement and dead space can be evaluated as an appropriate treatment method in patients with high flow rate seroma.

There are various surgical and invasive treatment systems such as conservative skin grafts and autologous epider-mal grafting (AEG) for diabetic foot ulcers. This study aims to evaluate the feasibility of using a novel epidermal graft harvesting system in diabetic foot ulcer emergencies. A retrospective clinical study was conducted with 15 diabetic foot ulcer patients, and after written and signed consent forms were taken, AEG system was applied to all patients. All of the clinical data of the patients such as their American Society of Anesthesiologists (ASA) Physical Status Classification System scores, size of pre-application wound area (cm2), time to complete re-epithelization of the wound, pain scores using the visual analog scale (VAS) for both donor and recipient sites, changes in size of wound, complete dermal response time, and patients' demographics, comorbidities were recorded. The age, gender, pre-post appli-cation wound area (cm2), time of healing, ASA, and VAS variables were compared each other and analyzed statistically. P<0.05 was considered as statistically significant. The mean of time for complete wound healing was 5.9 (range 4-8) weeks. There was no statistically difference between recipient wound size and patient's age; size of both types of wounds (cm2) and time (weeks) for complete reduction for both types of wounds; and time to complete both types of wound healing and gender (p=0.509, 0.788, and 0.233, respectively). ASA scores did not impact the time required for complete healing of the wound (p=0.749). The current study has tried to evaluate the efficacy of the AEG system in a homogenous population with diabetic foot ulcers. An epidermal harvesting system may be used effectively and safely in patients with diabetic foot ulcer emergencies.

Background and Objectives: Obesity may adversely affect cardiovascular function and cardiac electrical activity. This study aimed to evaluate electrocardiographic indices of ventricular repolarisation in morbidly obese individuals compared with non-obese controls. Materials and Methods: This retrospective, single-centre study included 112 morbidly obese individuals with a body mass index >40 kg/m² and 51 non-obese controls. QT and Tp-e intervals and Tp-e/QT ratios were measured from resting ECG recordings. Heart-rate-corrected QT intervals were calculated using the Bazett and Fridericia formulae. Between-group comparisons, multivariable regression analyses, sensitivity analyses, and exploratory analyses of iron metabolism parameters were performed. Multiple comparisons were adjusted using the Benjamini–Hochberg false discovery rate (FDR) procedure. Results: Morbidly obese individuals had a shorter RR interval (p = 0.020) and higher QTc-Bazett (p = 0.016) and Tp-e/QT (p = 0.030) than controls; however, these differences did not remain significant after FDR correction (all adjusted p = 0.080). QTc-Fridericia did not differ between groups (p = 0.240). After multivariable adjustment, morbid obesity was not significantly associated with Tp-e/QT (p = 0.338) or QTc-Fridericia (p = 0.177). A sensitivity analysis restricted to morbidly obese individuals without recorded comorbidities similarly showed no significant differences in ventricular repolarisation indices after FDR correction. Within the morbidly obese group, men had higher Tp-e-based indices than women after FDR correction. Exploratory analyses showed associations between iron metabolism parameters and Tp-e-based indices, with ln-ferritin remaining positively associated with Tp-e/QT after adjustment (p = 0.012). Conclusions: The present findings did not demonstrate a consistent association between morbid obesity alone and altered ventricular repolarisation, as the observed between-group differences were not robust across multiple-comparison correction, adjusted analyses, and sensitivity analyses. Sex-related differences and exploratory associations with iron metabolism suggest a multifactorial influence on ventricular repolarisation in morbid obesity. These findings warrant prospective validation using direct arrhythmic outcomes.