Background and Objectives: The relationship between psychiatric disorders and systemic inflammation remains incompletely understood. Increasing evidence suggests that inflammatory processes may play a role in the biological mechanisms underlying suicidal behavior. This study aimed to investigate the association between classical inflammatory markers and hemogram-derived inflammatory indices in patients who attempted suicide by oral drug overdose. Materials and Methods: This retrospective observational comparative study included 343 patients hospitalized following a suicide attempt by oral medication overdose and 421 age- and sex-matched healthy individuals. Serum C-reactive protein (CRP), albumin levels, complete blood count parameters, and derived inflammatory indices, including the CRP-to-albumin ratio (CAR), neutrophil-to-lymphocyte ratio (NLR), systemic immune–inflammation index (SIII), platelet-to-lymphocyte ratio (PLR), and monocyte-to-lymphocyte ratio (MLR), were analyzed. Results: Patients with suicide attempts had significantly higher CRP, leukocyte, neutrophil, and monocyte levels compared to the comparison group. CAR, NLR, SIII, and MLR values were also significantly elevated, whereas PLR did not differ between groups. ROC analysis demonstrated that CAR showed the highest discriminative ability for suicide attempt, with high sensitivity and specificity. Conclusions: Hemogram-derived inflammatory indices, particularly CAR, were significantly associated with suicide attempts. These easily accessible and low-cost biomarkers may provide additional biological insight into suicide risk assessment. Further prospective studies are needed to confirm these findings.

Background: Osteoporosis has a rising global incidence and social burden. Serum uric acid’s dual roles in oxidative stress and inflammation may influence bone health, but findings are inconsistent and require further research. This study aimed to evaluate the relationship between SUA levels and osteoporosis in a multicenter cohort obtained from different regions of Türkiye. Methods: This multi-center retrospective study included 3280 individuals, postmenopausal women and men aged 45 and older, from 16 centers in Türkiye. Individuals were excluded if they recently consumed alcohol, had severe renal dysfunction, certain hormonal or mineral disorders, specific medications, or certain menopausal statuses. Bone mineral density (BMD) at the hip and lumbar spine was measured using dual-energy X-ray absorptiometry (DXA), and participants were classified as normal or having osteopenia or osteoporosis based on T-score thresholds. Results: Overall, 34.8% were male, and 65.2% were female. For the lumbar spine, 36.8% had osteopenia, and 13.5% had osteoporosis; similarly, for the total hip, 40.8% had osteopenia, and 7.9% had osteoporosis. ROC analysis identified a threshold of 3.9 mg/dL serum uric acid (SUA) (AUC 0.374; p < 0.001), which was positively associated with both lumbar and total hip BMD. Osteoporosis rates were higher in patients with SUA < 3.9 mg/dL compared to those with SUA ≥ 3.9 mg/dL at the lumbar spine (29.1% vs. 14.2%, p < 0.001) and total hip sites (23.6% vs. 15.9%, p = 0.003). After adjustment for potential confounders, SUA was a significant independent predictor of osteoporosis in the lumbar spine (OR 0.70; p < 0.001) and the hip (OR 0.80; p < 0.001). Conclusions: Serum uric acid levels are inversely linked to bone mineral density and osteoporosis risk, indicating a potential role in bone health. However, due to study limitations, causal relationships remain unproven, and further research is needed.

Background: The C-reactive protein–albumin–lymphocyte (CALLY) index integrates systemic inflammation, nutritional status, and immune function. This study evaluated changes in the CALLY index after sleeve gastrectomy and their associations with weight loss and cardiometabolic changes in women. Methods: This retrospective, observational, single-center study included 72 women who underwent sleeve gastrectomy and had complete preoperative and 12-month postoperative data. The CALLY index was calculated preoperatively and at 12 months. ΔCALLY was defined as the 12-month value minus the preoperative value. Weight-loss outcomes were assessed using total weight loss (TWL) and excess weight loss (EWL). Associations were evaluated using Spearman’s rank correlation analysis and multivariable linear regression. Results: The CALLY index increased from 1.70 [0.87–2.56] preoperatively to 6.94 [2.72–15.54] at 12 months (p < 0.001). Mean TWL and EWL were 31.43 ± 7.83% and 73.30 ± 20.12%, respectively. ΔCALLY correlated positively with TWL (r = 0.303, p = 0.010) and EWL (r = 0.312, p = 0.008) and negatively with ΔBMI (r = −0.250, p = 0.035), Δfasting insulin (r = −0.234, p = 0.046), ΔHOMA-IR (r = −0.243, p = 0.040), and Δtriglycerides (r = −0.254, p = 0.031). After adjustment for age, preoperative BMI, and diabetes mellitus, ΔCALLY remained positively associated with TWL (B = 0.342, 95% CI 0.172–0.513; p < 0.001). Conclusions: The CALLY index increased significantly during the first year after sleeve gastrectomy in women. Changes in the CALLY index were associated with weight loss and changes in selected metabolic parameters. ΔCALLY may reflect inflammatory and immunonutritional changes accompanying postoperative weight loss.

Background and Objectives: Obesity may adversely affect cardiovascular function and cardiac electrical activity. This study aimed to evaluate electrocardiographic indices of ventricular repolarisation in morbidly obese individuals compared with non-obese controls. Materials and Methods: This retrospective, single-centre study included 112 morbidly obese individuals with a body mass index >40 kg/m² and 51 non-obese controls. QT and Tp-e intervals and Tp-e/QT ratios were measured from resting ECG recordings. Heart-rate-corrected QT intervals were calculated using the Bazett and Fridericia formulae. Between-group comparisons, multivariable regression analyses, sensitivity analyses, and exploratory analyses of iron metabolism parameters were performed. Multiple comparisons were adjusted using the Benjamini–Hochberg false discovery rate (FDR) procedure. Results: Morbidly obese individuals had a shorter RR interval (p = 0.020) and higher QTc-Bazett (p = 0.016) and Tp-e/QT (p = 0.030) than controls; however, these differences did not remain significant after FDR correction (all adjusted p = 0.080). QTc-Fridericia did not differ between groups (p = 0.240). After multivariable adjustment, morbid obesity was not significantly associated with Tp-e/QT (p = 0.338) or QTc-Fridericia (p = 0.177). A sensitivity analysis restricted to morbidly obese individuals without recorded comorbidities similarly showed no significant differences in ventricular repolarisation indices after FDR correction. Within the morbidly obese group, men had higher Tp-e-based indices than women after FDR correction. Exploratory analyses showed associations between iron metabolism parameters and Tp-e-based indices, with ln-ferritin remaining positively associated with Tp-e/QT after adjustment (p = 0.012). Conclusions: The present findings did not demonstrate a consistent association between morbid obesity alone and altered ventricular repolarisation, as the observed between-group differences were not robust across multiple-comparison correction, adjusted analyses, and sensitivity analyses. Sex-related differences and exploratory associations with iron metabolism suggest a multifactorial influence on ventricular repolarisation in morbid obesity. These findings warrant prospective validation using direct arrhythmic outcomes.