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Bin Zhang
Wuhan Children’s Hospital (Wuhan Maternal and Child Healthcare Hospital), Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China

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Original article
Published: 24 March 2020 in European Journal of Pediatrics
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The aim of our study was to investigate the relationship between maternal age at menarche and newborn telomere length which has been linked to lifespan and many age-related diseases. There were 734 mother-newborn pairs recruited from Wuhan Children’s Hospital Wuhan, Hubei Province, China. Age at menarche was self-reported and categorized into three groups (≤ 12 years, 13 years, and ≥ 14 years). Telomere length in cord blood was measured using quantitative real-time polymerase chain reaction and expressed as the ratio of telomere copy number to single-copy gene number (T/S). The mean age at menarche of 734 mothers was 13.1 (± 1.1) years and the adjusted geometric means in the T/S of newborn telomeres in the three groups were 0.693, 0.721, and 0.748 respectively. Earlier age at menarche (≤ 12 years), compared with later age at menarche ≥ 14 years, was significantly associated with 7.32% (95% CI − 13.70%, − 0.23%) shorter telomere length in offspring after adjusting for potential confounders. Conclusion: Mothers with earlier age at menarche were more likely to give birth newborn with shorter telomere length. Our study provides evidences for the effect of earlier menarche on fetal telomere programming in offspring.

ACS Style

Lulin Wang; Lulu Song; Bingqing Liu; Lina Zhang; Mingyang Wu; Wei Xia; Yuanyuan Li; Chao Xiong; Zhongqiang Cao; Shunqing Xu; Bin Zhang; Yaohua Tian; Youjie Wang. Earlier maternal menarche is associated with shorter newborn telomere length. European Journal of Pediatrics 2020, 179, 1507 -1513.

AMA Style

Lulin Wang, Lulu Song, Bingqing Liu, Lina Zhang, Mingyang Wu, Wei Xia, Yuanyuan Li, Chao Xiong, Zhongqiang Cao, Shunqing Xu, Bin Zhang, Yaohua Tian, Youjie Wang. Earlier maternal menarche is associated with shorter newborn telomere length. European Journal of Pediatrics. 2020; 179 (10):1507-1513.

Chicago/Turabian Style

Lulin Wang; Lulu Song; Bingqing Liu; Lina Zhang; Mingyang Wu; Wei Xia; Yuanyuan Li; Chao Xiong; Zhongqiang Cao; Shunqing Xu; Bin Zhang; Yaohua Tian; Youjie Wang. 2020. "Earlier maternal menarche is associated with shorter newborn telomere length." European Journal of Pediatrics 179, no. 10: 1507-1513.

Population study article
Published: 04 February 2020 in Pediatric Research
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BackgroundMaternal hypertensive disorders of pregnancy (HDP) are the major causes of maternal mortality. However, the association between HDP and offspring’s neurodevelopment remains unclear.MethodParticipants were 4031 singleton live births from a prospective cohort study in Wuhan, China, during October 2013 to October 2014. Neurodevelopment of infant was evaluated by using Chinese version of Gesell Developmental Schedules at 0.5 year of age. Maternal HDP and potential confounders were ascertained by healthcare records at baseline.ResultsGeneralized linear model analysis indicated that maternal chronic hypertension were significantly associated with development quotient on fine motor (β = −3.32, 95% CI: −6.33 to −0.31), adaptability (β = −2.87, 95% CI: −5.31 to −0.43), language (β = −1.23, 95% CI: −2.12 to −0.34) and social behavior (β = −2.53, 95% CI: −4.69 to −0.37), and gestational hypertension was significantly associated with development quotient on social behavior (β = −1.42, 95% CI: −2.03 to −0.81), even after adjustment of major confounders. Multivariable logistic regression analysis showed that maternal chronic hypertension also increased the risk of diagnosis of “neurodevelopmental delay” on fine motor (OR = 1.85, 95% CI: 1.19−2.89), adaptability (OR = 2.32, 95% CI: 1.42−3.78), language (OR = 2.86, 95% CI: 1.74−4.70), and social behavior (OR = 2.13, 95% CI: 1.73−2.59).ConclusionThis study suggests that exposure to HDP is associated with an increased risk of neurodevelopment impairment in the offspring at the age of 0.5 year.

ACS Style

Zhong Chen; Ruizhen Li; Hua Liu; Junyu Duan; Cong Yao; Rong Yang; Yaqi Zhang; Lin Qiu; Chao Xiong; Jieqiong Zhou; Bin Zhang. Impact of maternal hypertensive disorders on offspring’s neurodevelopment: a longitudinal prospective cohort study in China. Pediatric Research 2020, 88, 668 -675.

AMA Style

Zhong Chen, Ruizhen Li, Hua Liu, Junyu Duan, Cong Yao, Rong Yang, Yaqi Zhang, Lin Qiu, Chao Xiong, Jieqiong Zhou, Bin Zhang. Impact of maternal hypertensive disorders on offspring’s neurodevelopment: a longitudinal prospective cohort study in China. Pediatric Research. 2020; 88 (4):668-675.

Chicago/Turabian Style

Zhong Chen; Ruizhen Li; Hua Liu; Junyu Duan; Cong Yao; Rong Yang; Yaqi Zhang; Lin Qiu; Chao Xiong; Jieqiong Zhou; Bin Zhang. 2020. "Impact of maternal hypertensive disorders on offspring’s neurodevelopment: a longitudinal prospective cohort study in China." Pediatric Research 88, no. 4: 668-675.

Journal article
Published: 06 February 2019 in BMC Medicine
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Newborn telomere length (TL) is considered a potential marker for future disease and lifelong health, but few epidemiological studies have examined the determinants of TL in early life. The study aim was to investigate whether there is an association between prenatal cadmium exposure and relative cord blood TL in Chinese newborns. Participants were 410 mother–newborn pairs drawn from a prospective birth cohort study conducted in Wuhan, China, between November 2013 and March 2015. Urine samples were collected from pregnant women during their period of institutional delivery. Urinary cadmium concentrations were measured by inductively coupled plasma mass spectrometry. The real-time quantitative polymerase chain reaction detection was used to measure relative TL using genomic DNA isolated from umbilical cord blood leukocytes. Multivariate linear regression models were used to estimate the effect of prenatal urinary cadmium concentration on relative cord blood TL. The geometric mean of maternal urinary cadmium concentration was 0.68 μg/g creatinine. In the multivariate-adjusted linear regression model, per doubling of maternal urinary cadmium concentration was associated with 6.83% (95% CI − 11.44%, − 1.97%; P = 0.006) shorter relative cord blood TL. Stratified analyses indicated that the inverse association between prenatal urinary cadmium and newborn relative TL was more pronounced among female infants and mothers < 29 years, while there were no significant effect modification according to infant sex (P for interaction = 0.907) and maternal age (P for interaction = 0.797). The findings indicated that increased maternal urinary cadmium was associated with shortened relative cord blood TL. The results provide more evidence of the negative effects of environmental cadmium exposure and suggest that accelerated aging or cadmium-related diseases may begin in early life.

ACS Style

Lina Zhang; Lulu Song; Bingqing Liu; Mingyang Wu; Lulin Wang; Bin Zhang; Chao Xiong; Wei Xia; Yuanyuan Li; Zhongqiang Cao; Youjie Wang; Shunqing Xu. Prenatal cadmium exposure is associated with shorter leukocyte telomere length in Chinese newborns. BMC Medicine 2019, 17, 1 -8.

AMA Style

Lina Zhang, Lulu Song, Bingqing Liu, Mingyang Wu, Lulin Wang, Bin Zhang, Chao Xiong, Wei Xia, Yuanyuan Li, Zhongqiang Cao, Youjie Wang, Shunqing Xu. Prenatal cadmium exposure is associated with shorter leukocyte telomere length in Chinese newborns. BMC Medicine. 2019; 17 (1):1-8.

Chicago/Turabian Style

Lina Zhang; Lulu Song; Bingqing Liu; Mingyang Wu; Lulin Wang; Bin Zhang; Chao Xiong; Wei Xia; Yuanyuan Li; Zhongqiang Cao; Youjie Wang; Shunqing Xu. 2019. "Prenatal cadmium exposure is associated with shorter leukocyte telomere length in Chinese newborns." BMC Medicine 17, no. 1: 1-8.

Journal article
Published: 21 August 2018 in Scientific Reports
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To assess the relationship between gestational weight gain (GWG) of twin-pregnancy women and twin birth weights, as well as to evaluate whether pre-pregnancy body mass index (BMI) influences this relationship. A cohort study was conducted in Wuhan, China, between 1/01/2011 and 8/31/2017. Women with twin pregnancies who delivered live and non-malformed twins were included (6,925 women and 13,850 infants), based on the Wuhan Maternal and Child Health Management Information System. Logistic regression models were employed to examine the association between GWG and paired small for gestational age (SGA, defined as birth weight <10th percentile for gestational age and sex)/SGA and linear regression models were utilized to explore the relationship between GWG and sum of birth weights. The associations of GWG based on both the IOM and Chinese recommendations and SGA/SGA pairs were obtained, as well as the stratified analyses by pre-pregnancy BMI. Additionally, the sum birth weight of one twin pair increased by 15.88 g when the GWG increased by 1 kg. GWG below the IOM and Chinese recommendations was associated with an increased risk of SGA/SGA pairs in all pre-pregnancy BMI categories. However, in underweight, overweight, and obese women, the association between GWG above the IOM and Chinese recommendations and SGA/SGA pairs changed with adjustment.

ACS Style

Yawen Chen; Yan Liu; Yiming Zhang; Ronghua Hu; Zhengmin Qian; Hong Xian; Michael G. Vaughn; Mingzhu Liu; Shiyi Cao; Yong Gan; Bin Zhang. Gestational Weight Gain per Pre-Pregnancy Body Mass Index and Birth Weight in Twin Pregnancies: A Cohort Study in Wuhan, China. Scientific Reports 2018, 8, 12496 .

AMA Style

Yawen Chen, Yan Liu, Yiming Zhang, Ronghua Hu, Zhengmin Qian, Hong Xian, Michael G. Vaughn, Mingzhu Liu, Shiyi Cao, Yong Gan, Bin Zhang. Gestational Weight Gain per Pre-Pregnancy Body Mass Index and Birth Weight in Twin Pregnancies: A Cohort Study in Wuhan, China. Scientific Reports. 2018; 8 (1):12496.

Chicago/Turabian Style

Yawen Chen; Yan Liu; Yiming Zhang; Ronghua Hu; Zhengmin Qian; Hong Xian; Michael G. Vaughn; Mingzhu Liu; Shiyi Cao; Yong Gan; Bin Zhang. 2018. "Gestational Weight Gain per Pre-Pregnancy Body Mass Index and Birth Weight in Twin Pregnancies: A Cohort Study in Wuhan, China." Scientific Reports 8, no. 1: 12496.

Journal article
Published: 09 January 2017 in International Journal of Environmental Research and Public Health
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Prenatal cadmium (Cd) exposure has been associated with adverse birth outcomes, but the findings of previous studies are inconsistent. We measured Cd concentrations in urine samples at or near 13, 24, and 35 gestational weeks from 282 women in Wuhan, China. We used generalized estimating equation models to assess the associations between maternal creatinine adjusted urinary Cd concentrations at each trimester and birth size. A significant inverse association was observed between higher maternal Cd levels measured during the 1st trimester and birth size in girls. For each log unit increase in Cd (µg/g creatinine) levels from the 1st trimester, there was a decrease in birth weight by 116.99 g (95% confidence interval (CI): −208.87, −25.11 g). The Cd levels from the 1st and 2nd trimesters were also borderline significantly associated with ponderal index in girls. Joint estimation of trimester-specific effects suggested that associations with Cd levels for ponderal index (pint = 0.02) were significantly different across trimesters, and differences for effects across trimesters for birth weight were marginally significant (pint = 0.08) in girls. No significant associations were observed between Cd levels from any trimester and birth size in boys. Maternal Cd exposure during earlier periods of pregnancy may have a larger impact on delayed fetal growth.

ACS Style

Lu Cheng; Bin Zhang; Tongzhang Zheng; Jie Hu; Aifen Zhou; Bryan A. Bassig; Wei Xia; David A. Savitz; Stephen Buka; Chao Xiong; Joseph M. Braun; Yaqi Zhang; Yanqiu Zhou; Xinyun Pan; Chuansha Wu; Youjie Wang; Zhengmin Qian; Aimin Yang; Megan E. Romano; Kunchong Shi; Shunqing Xu; Yuanyuan Li. Critical Windows of Prenatal Exposure to Cadmium and Size at Birth. International Journal of Environmental Research and Public Health 2017, 14, 58 .

AMA Style

Lu Cheng, Bin Zhang, Tongzhang Zheng, Jie Hu, Aifen Zhou, Bryan A. Bassig, Wei Xia, David A. Savitz, Stephen Buka, Chao Xiong, Joseph M. Braun, Yaqi Zhang, Yanqiu Zhou, Xinyun Pan, Chuansha Wu, Youjie Wang, Zhengmin Qian, Aimin Yang, Megan E. Romano, Kunchong Shi, Shunqing Xu, Yuanyuan Li. Critical Windows of Prenatal Exposure to Cadmium and Size at Birth. International Journal of Environmental Research and Public Health. 2017; 14 (1):58.

Chicago/Turabian Style

Lu Cheng; Bin Zhang; Tongzhang Zheng; Jie Hu; Aifen Zhou; Bryan A. Bassig; Wei Xia; David A. Savitz; Stephen Buka; Chao Xiong; Joseph M. Braun; Yaqi Zhang; Yanqiu Zhou; Xinyun Pan; Chuansha Wu; Youjie Wang; Zhengmin Qian; Aimin Yang; Megan E. Romano; Kunchong Shi; Shunqing Xu; Yuanyuan Li. 2017. "Critical Windows of Prenatal Exposure to Cadmium and Size at Birth." International Journal of Environmental Research and Public Health 14, no. 1: 58.

Journal article
Published: 19 November 2015 in International Journal of Hygiene and Environmental Health
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Although studies in western countries suggest that ambient air pollution is positively associated with adverse pregnancy outcomes, the upper levels of pollutant exposures have been relatively low, thus eroding confidence in the conclusions. Meanwhile, in Asia, where upper levels of exposure have been greater, there have been limited studies of the association between air pollution and adverse pregnancy outcomes. The primary objective was to evaluate whether high levels of pollution, including particulate matter pollution with a mass median aerodynamic diameter of less than 2.5 μm (PM2.5) and 10 μm (PM10), sulfur dioxide (SO2), nitrogen dioxide (NO2), ozone (O3), and carbon monoxide (CO) are related to increased occurrence of preterm birth (PTB). We conducted a population-based study in Wuhan, China in a cohort of 95,911 live births during a two-year period from 2011 to 2013. The exposure was estimated based on daily mean concentrations of pollutants estimated using the pollutants’ measurements from the nine closest monitors. Logistic regressions were performed to determine the relationships between exposure to each of the pollutants during different pregnancy periods and PTB while controlling for key covariates. We found 3% (OR = 1.03; 95% CI: 1.02, 1.05), 2% (OR = 1.02; 95% CI: 1.02, 1.03), 15% (OR = 1.15; 95% CI: 1.11, 1.19), and 5% (OR = 1.05; 95% CI: 1.02, 1.07) increases in risk of PTB with each 5-μg/m3 increase in PM2.5 and PM10 concentrations, 100-μg/m3 increase in CO concentrations, and 10-μg/m3 increase in O3 concentrations, respectively. There was negligible evidence for associations for SO2 and NO2. The effects from two-pollutant models were similar to the estimated effects from single pollutant models. No critical exposure windows were identified consistently: the strongest effect for PTB was found in the second trimester for PM2.5, PM10, and CO, but for SO2 it was in the first trimester, second month, and third month. For NO2 it was in the first trimester and second month, and for O3, the third trimester. Findings reveal an association between air pollutants and PTB. However, more toxicological studies and prospective cohort studies with improved exposure assessments are needed to establish causality related to specific pollutants.

ACS Style

Zhengmin Qian; Shengwen Liang; Shaoping Yang; Edwin Trevathan; Zhen Huang; Rong Yang; Jing Wang; Ke Hu; Yiming Zhang; Michael Vaughn; Longjiao Shen; Wenjin Liu; Pu Li; Patrick Ward; Li Yang; Wei Zhang; Wei Chen; Guang-Hui Dong; Tongzhang Zheng; Shunqing Xu; Bin Zhang. Ambient air pollution and preterm birth: A prospective birth cohort study in Wuhan, China. International Journal of Hygiene and Environmental Health 2015, 219, 195 -203.

AMA Style

Zhengmin Qian, Shengwen Liang, Shaoping Yang, Edwin Trevathan, Zhen Huang, Rong Yang, Jing Wang, Ke Hu, Yiming Zhang, Michael Vaughn, Longjiao Shen, Wenjin Liu, Pu Li, Patrick Ward, Li Yang, Wei Zhang, Wei Chen, Guang-Hui Dong, Tongzhang Zheng, Shunqing Xu, Bin Zhang. Ambient air pollution and preterm birth: A prospective birth cohort study in Wuhan, China. International Journal of Hygiene and Environmental Health. 2015; 219 (2):195-203.

Chicago/Turabian Style

Zhengmin Qian; Shengwen Liang; Shaoping Yang; Edwin Trevathan; Zhen Huang; Rong Yang; Jing Wang; Ke Hu; Yiming Zhang; Michael Vaughn; Longjiao Shen; Wenjin Liu; Pu Li; Patrick Ward; Li Yang; Wei Zhang; Wei Chen; Guang-Hui Dong; Tongzhang Zheng; Shunqing Xu; Bin Zhang. 2015. "Ambient air pollution and preterm birth: A prospective birth cohort study in Wuhan, China." International Journal of Hygiene and Environmental Health 219, no. 2: 195-203.